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Atf2 activating transcription factor 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 81647, updated on 17-May-2016
Official Symbol
Atf2provided by RGD
Official Full Name
activating transcription factor 2provided by RGD
Primary source
RGD:621862
See related
Ensembl:ENSRNOG00000001597
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Summary
transactivates tyrosine hydroxylase transcription; may be involved in regulation of catecholamine synthesis during neural development [RGD, Feb 2006]
Orthologs
Location:
3q23
Exon count:
14
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (60721137..60795951, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 3 NC_005102.3 (67199880..67274694, complement)

Chromosome 3 - NC_005102.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102552328 Neighboring gene chimerin 1 Neighboring gene high mobility group protein B1-like Neighboring gene ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9) Neighboring gene NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1-like

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
DNA binding ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II activating transcription factor binding IEA
Inferred from Electronic Annotation
more info
 
RNA polymerase II activating transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II distal enhancer sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
RNA polymerase II distal enhancer sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
cAMP response element binding IDA
Inferred from Direct Assay
more info
PubMed 
cAMP response element binding ISO
Inferred from Sequence Orthology
more info
 
cAMP response element binding protein binding IEA
Inferred from Electronic Annotation
more info
 
cAMP response element binding protein binding ISO
Inferred from Sequence Orthology
more info
 
chromatin binding IEA
Inferred from Electronic Annotation
more info
 
chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enhancer sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
histone acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
histone acetyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IEA
Inferred from Electronic Annotation
more info
 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor activity, sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IEA
Inferred from Electronic Annotation
more info
 
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
adipose tissue development IEA
Inferred from Electronic Annotation
more info
 
adipose tissue development ISO
Inferred from Sequence Orthology
more info
 
amelogenesis IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to DNA damage stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to DNA damage stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
fat cell differentiation IEA
Inferred from Electronic Annotation
more info
 
fat cell differentiation ISO
Inferred from Sequence Orthology
more info
 
histone acetylation IEA
Inferred from Electronic Annotation
more info
 
intra-S DNA damage checkpoint ISO
Inferred from Sequence Orthology
more info
 
intra-S DNA damage checkpoint ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
PubMed 
outflow tract morphogenesis IEA
Inferred from Electronic Annotation
more info
 
outflow tract morphogenesis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of mitochondrial membrane permeability involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of mitochondrial membrane permeability involved in apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of sequence-specific DNA binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of sequence-specific DNA binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transforming growth factor beta2 production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transforming growth factor beta2 production ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
response to osmotic stress ISO
Inferred from Sequence Orthology
more info
 
response to osmotic stress ISS
Inferred from Sequence or Structural Similarity
more info
 
response to water deprivation IEP
Inferred from Expression Pattern
more info
PubMed 
transcription from RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 
mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
 
mitochondrial outer membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
site of double-strand break ISO
Inferred from Sequence Orthology
more info
 
site of double-strand break ISS
Inferred from Sequence or Structural Similarity
more info
 
Preferred Names
cyclic AMP-dependent transcription factor ATF-2
Names
cAMP response element-binding protein CRE-BP1
cAMP-dependent transcription factor ATF-2
NP_112280.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031018.1NP_112280.1  cyclic AMP-dependent transcription factor ATF-2

    See identical proteins and their annotated locations for NP_112280.1

    Status: PROVISIONAL

    Source sequence(s)
    U38938
    UniProtKB/Swiss-Prot
    Q00969
    Related
    ENSRNOP00000002174, ENSRNOT00000002174
    Conserved Domains (3) summary
    cd12192
    Location:4784
    GCN4_cent; GCN4 central activation domain-like acidic activation domain
    cd14687
    Location:336396
    bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
    sd00019
    Location:931
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005102.4 Reference Rnor_6.0 Primary Assembly

    Range
    60721137..60795951 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000071.1 Alternate Rn_Celera

    Range
    58247269..58321865 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)