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Abat 4-aminobutyrate aminotransferase [ Rattus norvegicus (Norway rat) ]

Gene ID: 81632, updated on 26-May-2016
Official Symbol
Abatprovided by RGD
Official Full Name
4-aminobutyrate aminotransferaseprovided by RGD
Primary source
RGD:620948
See related
Ensembl:ENSRNOG00000002636
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as
Gabat; beta-AlaAT
Summary
main component of the 4-aminobutyrate (GABA) shunt; major inhibitory neurotransmitter [RGD, Feb 2006]
Orthologs
Location:
10q12
Exon count:
17
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (7094246..7200439, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 10 NC_005109.3 (5894187..6002068, complement)

Chromosome 10 - NC_005109.4Genomic Context describing neighboring genes Neighboring gene phosphomannomutase 2 Neighboring gene transmembrane protein 186 Neighboring gene methyltransferase like 22 Neighboring gene transmembrane protein 114

Markers

Homology

Clone Names

  • MGC93392

Gene Ontology Provided by RGD

Function Evidence Code Pubs
(S)-3-amino-2-methylpropionate transaminase activity IEA
Inferred from Electronic Annotation
more info
 
4-aminobutyrate transaminase activity IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to 4-aminobutyrate transaminase activity ISO
Inferred from Sequence Orthology
more info
 
contributes_to 4-aminobutyrate transaminase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
identical protein binding IBA
Inferred from Biological aspect of Ancestor
more info
 
iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
pyridoxal phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
 
pyridoxal phosphate binding ISO
Inferred from Sequence Orthology
more info
 
pyridoxal phosphate binding ISS
Inferred from Sequence or Structural Similarity
more info
 
succinate-semialdehyde dehydrogenase binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
aging IDA
Inferred from Direct Assay
more info
PubMed 
behavioral response to cocaine ISO
Inferred from Sequence Orthology
more info
 
behavioral response to cocaine ISS
Inferred from Sequence or Structural Similarity
more info
 
cerebellum development IEP
Inferred from Expression Pattern
more info
PubMed 
copulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
exploration behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
gamma-aminobutyric acid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
gamma-aminobutyric acid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
gamma-aminobutyric acid catabolic process IC
Inferred by Curator
more info
PubMed 
locomotory behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of blood pressure IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of dopamine secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of gamma-aminobutyric acid secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of platelet aggregation IMP
Inferred from Mutant Phenotype
more info
PubMed 
neurotransmitter catabolic process IC
Inferred by Curator
more info
PubMed 
positive regulation of aspartate secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of dopamine metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of heat generation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of inhibitory postsynaptic potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of insulin secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of prolactin secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of uterine smooth muscle contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to cocaine IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to drug IDA
Inferred from Direct Assay
more info
PubMed 
response to ethanol IDA
Inferred from Direct Assay
more info
PubMed 
response to hypoxia IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to iron ion IDA
Inferred from Direct Assay
more info
PubMed 
response to nicotine IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
4-aminobutyrate transaminase complex ISO
Inferred from Sequence Orthology
more info
 
4-aminobutyrate transaminase complex ISS
Inferred from Sequence or Structural Similarity
more info
 
extracellular exosome IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
mitochondrial matrix IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
 
neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
4-aminobutyrate aminotransferase, mitochondrial
Names
(S)-3-amino-2-methylpropionate transaminase
GABA aminotransferase
GABA transaminase
GABA-AT
GABA-T
L-AIBAT
gamma-amino-N-butyrate transaminase
NP_112265.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031003.2NP_112265.1  4-aminobutyrate aminotransferase, mitochondrial

    See identical proteins and their annotated locations for NP_112265.1

    Status: PROVISIONAL

    Source sequence(s)
    D87839
    UniProtKB/Swiss-Prot
    P50554
    Related
    ENSRNOP00000003633, ENSRNOT00000003633
    Conserved Domains (1) summary
    cd00610
    Location:78496
    OAT_like; Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase, ...

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005109.4 Reference Rnor_6.0 Primary Assembly

    Range
    7094246..7200439 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006245760.2XP_006245822.1  

    See identical proteins and their annotated locations for XP_006245822.1

    UniProtKB/Swiss-Prot
    P50554
    Conserved Domains (1) summary
    cd00610
    Location:78496
    OAT_like; Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase, ...

Alternate Rn_Celera

Genomic

  1. AC_000078.1 Alternate Rn_Celera

    Range
    5995207..6088218 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)