EMB2296 60S ribosomal protein L8-1 [Arabidopsis thaliana] - Gene

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Summary

Gene symbol: EMB2296
Gene description: 60S ribosomal protein L8-1
Primary source: TAIR:AT2G18020
Locus tag: AT2G18020
Gene type: protein coding
RNA name: 60S ribosomal protein L8-1
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliophyta; eudicotyledons; core eudicotyledons; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: embryo defective 2296; T27K22.11; T27K22_11

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Genomic context

Sequence :: Chromosome: 2; NC_003071.7 (7837102..7838304)

See EMB2296 in MapViewer

Chromosome 2 - NC_003071.7 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Submit: New GeneRIF Correction

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Interactions

Products	Interactant	Other Gene	Complex	Source	Pubs	Description
BioGRID:1671	BioGRID:111823	RAD23A		BioGRID	PubMed	Reconstituted Complex

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General gene information

Homology

Homologs of the EMB2296 gene: The EMB2296 gene is conserved in human, chimpanzee, dog, cow, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.pombe, S.cerevisiae, K.lactis, E.gossypii, M.grisea, N.crassa, rice, and P.falciparum.

Pathways from BioSystems

Cap-dependent Translation Initiation, organism-specific biosystem (from REACTOME)
Cap-dependent Translation Initiation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Eukaryotic Translation Elongation, organism-specific biosystem (from REACTOME)
Eukaryotic Translation Elongation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Eukaryotic Translation Initiation, organism-specific biosystem (from REACTOME)
Eukaryotic Translation Initiation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Eukaryotic Translation Termination, organism-specific biosystem (from REACTOME)
Eukaryotic Translation Termination, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Formation of a pool of free 40S subunits, organism-specific biosystem (from REACTOME)
Formation of a pool of free 40S subunits, organism-specific biosystemcomputationally inferred pathway (not manually curated)
GTP hydrolysis and joining of the 60S ribosomal subunit, organism-specific biosystem (from REACTOME)
GTP hydrolysis and joining of the 60S ribosomal subunit, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Gene Expression, organism-specific biosystem (from REACTOME)
Gene Expression, organism-specific biosystemcomputationally inferred pathway (not manually curated)
L13a-mediated translational silencing of Ceruloplasmin expression, organism-specific biosystem (from REACTOME)
L13a-mediated translational silencing of Ceruloplasmin expression, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Metabolism of proteins, organism-specific biosystem (from REACTOME)
Metabolism of proteins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Peptide chain elongation, organism-specific biosystem (from REACTOME)
Peptide chain elongation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Ribosome, organism-specific biosystem (from KEGG)
Ribosome, organism-specific biosystem
Ribosome
Ribosome, conserved biosystem (from KEGG)
Ribosome, conserved biosystem
Ribosome
Ribosome, eukaryotes, organism-specific biosystem (from KEGG)
Ribosome, eukaryotes, organism-specific biosystemStructural complex; Genetic information processing; Ribosome
SRP-dependent cotranslational protein targeting to membrane, organism-specific biosystem (from REACTOME)
SRP-dependent cotranslational protein targeting to membrane, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Translation, organism-specific biosystem (from REACTOME)
Translation, organism-specific biosystemcomputationally inferred pathway (not manually curated)

NM_127358.5

Supported by cDNAs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
protein binding	IPI Inferred from Physical Interaction more info	PubMed
structural constituent of ribosome	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
embryo development ending in seed dormancy	NAS Non-traceable Author Statement more info
translation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
chloroplast	IDA Inferred from Direct Assay more info	PubMed
cytosol	IDA Inferred from Direct Assay more info
cytosolic large ribosomal subunit	IDA Inferred from Direct Assay more info	PubMed
cytosolic ribosome	IDA Inferred from Direct Assay more info	PubMed
nucleolus	IDA Inferred from Direct Assay more info	PubMed
plasma membrane	IDA Inferred from Direct Assay more info	PubMed
ribosome	ISS Inferred from Sequence or Structural Similarity more info
vacuolar membrane	IDA Inferred from Direct Assay more info	PubMed
vacuole	IDA Inferred from Direct Assay more info	PubMed

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General protein information

Names: 60S ribosomal protein L8-1

NP_179393.1

embryo defective 2296 (EMB2296); FUNCTIONS IN: structural constituent of ribosome, protein binding; INVOLVED IN: translation, embryo development ending in seed dormancy; LOCATED IN: in 7 components; EXPRESSED IN: male gametophyte, guard cell, cultured cell; EXPRESSED DURING: L mature pollen stage, M germinated pollen stage; CONTAINS InterPro DOMAIN/s: Nucleic acid-binding, OB-fold (InterPro:IPR012340), Ribosomal protein L2 (InterPro:IPR002171), Translation protein SH3-like (InterPro:IPR008991), Nucleic acid-binding, OB-fold-like (InterPro:IPR016027), Ribosomal protein L2, C-terminal (InterPro:IPR022669), Ribosomal protein L2, domain 3 (InterPro:IPR014726), Ribosomal Proteins L2, RNA binding domain (InterPro:IPR022666), Ribosomal protein L2, conserved site (InterPro:IPR022671); BEST Arabidopsis thaliana protein match is: Ribosomal protein L2 family (TAIR:AT4G36130.1); Has 10660 Blast hits to 10653 proteins in 3642 species: Archae - 317; Bacteria - 5675; Metazoa - 457; Fungi - 292; Plants - 1219; Viruses - 0; Other Eukaryotes - 2700 (source: NCBI BLink).

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NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003071.7

Range

7837102..7838304

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_127358.5 → NP_179393.1 60S ribosomal protein L8-1 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/Swiss-Prot

P46286

Conserved Domains (3) summary

pfam00181
Location:11 – 90
Blast Score: 161

Ribosomal_L2; Ribosomal Proteins L2, RNA binding domain

PTZ00180
Location:1 – 258
Blast Score: 1123

PTZ00180; 60S ribosomal protein L8; Provisional

pfam03947
Location:96 – 231
Blast Score: 398

Ribosomal_L2_C; Ribosomal Proteins L2, C-terminal domain