My NCBISign In

Display Settings:

Format

Send to:

Choose Destination

    COIL coilin [ Homo sapiens ]

    Gene ID: 8161, updated on 11-May-2012
    Help top of page

    Summary

    Official Symbol
    COILprovided by HGNC
    Official Full Name
    coilinprovided by HGNC
    Primary source
    HGNC:2184
    See related
    Ensembl:ENSG00000121058; HPRD:02605; MIM:600272
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CLN80; p80-coilin
    Summary
    The protein encoded by this gene is an integral component of Cajal bodies (also called coiled bodies). Cajal bodies are nuclear suborganelles of varying number and composition that are involved in the post-transcriptional modification of small nuclear and small nucleolar RNAs. The N-terminus of the coilin protein directs its self-oligomerization while the C-terminus influences the number of nuclear bodies assembled per cell. Differential methylation and phosphorylation of coilin likely influences its localization among nuclear bodies and the composition and assembly of Cajal bodies. This gene has pseudogenes on chromosome 4 and chromosome 14. [provided by RefSeq, Jul 2008]
    Help top of page

    Genomic context

    Location :
    17q22-q23
    Sequence :
    Chromosome: 17; NC_000017.10 (55015560..55038411, complement)
    See COIL in Epigenomics, MapViewer

    Chromosome 17 - NC_000017.10Genomic Context describing neighboring genes Neighboring gene mouse mammary tumor virus receptor homolog 2 Neighboring gene tripartite motif containing 25 Neighboring gene microRNA 3614 Neighboring gene uncharacterized LOC100288781 Neighboring gene ribosomal protein S15a pseudogene Neighboring gene serine carboxypeptidase 1 Neighboring gene ring finger protein 126 pseudogene 1

    Help top of page

    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
    Helptop of page

    Bibliography

    Related articles in PubMed

    1. Integrative analysis of the ubiquitin proteome isolated using Tandem Ubiquitin Binding Entities (TUBEs). Lopitz-Otsoa F, et al. J Proteomics, 2012 Jun 6. PMID 22178446.
    2. Coilin phosphomutants disrupt Cajal body formation, reduce cell proliferation and produce a distinct coilin degradation product. Carrero ZI, et al. PLoS One, 2011. PMID 21991343.
    3. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    4. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    5. Comparative proteomic analysis identifies a role for SUMO in protein quality control. Tatham MH, et al. Sci Signal, 2011 Jun 21. PMID 21693764.

    See all (54) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. These results emphasize the role of coilin phosphorylation in the formation and activity of Cajal bodies.
      Title: Coilin phosphomutants disrupt Cajal body formation, reduce cell proliferation and produce a distinct coilin degradation product.
    2. Results identify a novel and unexpected function for coilin, independent of its role in snRNP biogenesis, establishing a new link between the DNA damage response and the inhibition of rRNA synthesis.
      Title: Coilin participates in the suppression of RNA polymerase I in response to cisplatin-induced DNA damage.
    3. Data demonstrate by NMR methods that the carboxy-terminal region contains a Tudor domain.
      Title: Solution structure of the carboxy-terminal Tudor domain from human Coilin.
    4. results suggest the existence of a dynamic flux of coilin between Cajal bodies, nucleoplasm and nucleolus, and indicate that coilin methylation plays a key role in this process
      Title: Nucleolar targeting of coilin is regulated by its hypomethylation state.
    5. Observational study of gene-disease association. (HuGE Navigator)
      Title: The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature.
    6. in addition to affecting coilin-coilin interaction and localization in the nucleus, the phosphorylation state of coilin also impacts its interaction with SMN and SmB' and may play a role in controlling U snRNP cycling through the Cajal bodies.
      Title: Coilin phosphorylation mediates interaction with SMN and SmB'.
    7. Data support a model whereby coilin is the target of an uncharacterized signal transduction cascade that responds to the increased transcription and snRNP demands found in transformed cells.
      Title: Cajal-body formation correlates with differential coilin phosphorylation in primary and transformed cell lines.
    8. FLASH and NPAT positive but not Coilin positive Cajal Bodies correlate with cell ploidy.
      Title: FLASH and NPAT positive but not Coilin positive Cajal Bodies correlate with cell ploidy.
    9. These findings demonstrate that coilin modifications or levels impact artificial reporter splicing, possibly by influencing small nuclear ribonucleoprotein biogenesis.
      Title: Coilin levels and modifications influence artificial reporter splicing.
    10. p80 coilin protein co-localizes with ataxin-1 aggregates in the nucleoplasm
      Title: p80 coilin, a coiled body-specific protein, interacts with ataxin-1, the SCA1 gene product.
    Submit: New GeneRIF Correction See all (18)
    Help top of page

    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Many sequence variants affecting diversity of adult human height.

    Help top of page

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_004636.1 AAP37613.1 ANKS1B    BIND  PubMed AIDA-1a interacts with COIL. 
    NP_004636.1 AAV28691.1 ANKS1B    BIND  PubMed AIDA-1c interacts with COIL. 
    P38432 P12814 ACTN1    HPRD  PubMed  
    P38432 P35609 ACTN2    HPRD  PubMed  
    P38432 O43707 ACTN4    HPRD  PubMed  
    P38432 P54253 ATXN1    HPRD  PubMed  
    P38432 Q13895 BYSL    HPRD  PubMed  
    P38432 Q07021 C1QBP    HPRD  PubMed  
    P38432 Coiled-coil domain containing 136 CCDC136    HPRD  PubMed  
    P38432 P24864 CCNE1    HPRD  PubMed  
    P38432 P24941 CDK2    HPRD  PubMed  
    P38432 Q8NHQ1 CEP70    HPRD  PubMed  
    P38432 Q8TAP6 CEP76    HPRD  PubMed  
    P38432 P38432 COIL    HPRD  PubMed  
    P38432 P67870 CSNK2B    HPRD  PubMed  
    P38432 Cytochrome b5 reductase 2 CYB5R2    HPRD  PubMed  
    P38432 O60231 DHX16    HPRD  PubMed  
    P38432 Q96EY1 DNAJA3    HPRD  PubMed  
    P38432 KIAA0738 gene product FAM115A    HPRD  PubMed  
    P38432 Q5TD97 FHL5    HPRD  PubMed  
    P38432 P51116 FXR2    HPRD  PubMed  
    P38432 Q96CN9 GCC1    HPRD  PubMed  
    P38432 O60229 KALRN    HPRD  PubMed  
    P38432 Kazrin KAZN    HPRD  PubMed  
    P38432 Q9H0B6 KLC2    HPRD  PubMed  
    P38432 Q9NSK0 KLC4    HPRD  PubMed  
    P38432 Q9P2K6 KLHDC5    HPRD  PubMed  
    P38432 Q9P2G9 KLHL8    HPRD  PubMed  
    P38432 O00505 KPNA3    HPRD  PubMed  
    P38432 Q8TBB1 LNX1    HPRD  PubMed  
    P38432 Q9Y6D9 MAD1L1    HPRD  PubMed  
    P38432 Q9ULV0 MYO5B    HPRD  PubMed  
    P38432 Q9GZT8 NIF3L1    HPRD  PubMed  
    P38432 Q14978 NOLC1    HPRD  PubMed  
    P38432 NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18 NUDT18    HPRD  PubMed  
    P38432 Q8N2W9 PIAS4    HPRD  PubMed  
    P38432 Q9NRD5 PICK1    HPRD  PubMed  
    P38432 Q58EX7 PLEKHG4    HPRD  PubMed  
    P38432 Putative prolyl oligopeptidase PREPL    HPRD  PubMed  
    P38432 Q99873 PRMT1    HPRD  PubMed  
    P38432 Q9NR22 PRMT8    HPRD  PubMed  
    P38432 P25786 PSMA1    HPRD  PubMed  
    P38432 P61289 PSME3    HPRD  PubMed  
    P38432 Q15020 SART3    HPRD  PubMed  
    P38432 Q96KG9 SCYL1    HPRD  PubMed  
    P38432 Q16637 SMN2    HPRD  PubMed  
    P38432 P14678 SNRPB    HPRD  PubMed  
    P38432 Q9UNH7 SNX6    HPRD  PubMed  
    P38432 Q16594 TAF9    HPRD  PubMed  
    P38432 Q8IYF1 TCEB3B    HPRD  PubMed  
    P38432 Q12800 TFCP2    HPRD  PubMed  
    P38432 Q96RS0 TGS1    HPRD  PubMed  
    P38432 Cell division autoantigen 1 TSPYL2    HPRD  PubMed  
    P38432 Q96HA8 WDYHV1    HPRD  PubMed  
    P38432 P24278 ZBTB25    HPRD  PubMed  
    P38432 Q9NRM2 ZNF277    HPRD  PubMed  
    BioGRID:113815 BioGRID:112217 ATXN1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:113815 BioGRID:107338 CCNE1    BioGRID  PubMed Biochemical Activity 
    BioGRID:113815 BioGRID:113815 COIL    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:113815 BioGRID:114654 NOLC1    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:113815 BioGRID:203509 Nhp2l1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113815 BioGRID:112490 SMN1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113815 BioGRID:112512 SNRPB    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113815 BioGRID:112497 SUMO2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113815 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113815 BioGRID:113353 XRCC5    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113815 BioGRID:108822 XRCC6    BioGRID  PubMed Reconstituted Complex 
    Help top of page

    General gene information

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    disulfide oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein C-terminus binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    Cajal body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    female germ cell nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    Help top of page

    General protein information

    Preferred Names
    coilin
    Names
    coilin
    p80
    coilin p80
    Help top of page

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_004645.2 → NP_004636.1  coilin

      Status: REVIEWED

      Source sequence(s)
      AC004584, AW021880, BC010385
      Consensus CDS
      CCDS11592.1
      UniProtKB/Swiss-Prot
      P38432
      Related
      ENSP00000240316, ENST00000240316

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000017.10 Reference GRCh37.p5 Primary Assembly

      Range
      55015560..55038411, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000149.1 Alternate HuRef

      Range
      50376180..50399432, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC004584.2 (26121..48973) None
    genomic CH471109.2 EAW94522.1
    mRNA AK313616.1 BAG36378.1
    mRNA AW021880.1 None
    mRNA BC010385.1 AAH10385.1
    mRNA M58411.1 AAA36412.1
    mRNA U06632.1 AAB81550.1
    other-genetic DQ892927.2 ABM83853.1
    other-genetic DQ896176.2 ABM87175.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38432.1 GenPept UniProtKB/Swiss-Prot:P38432
    Help top of page

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Links

      Links to other resources

      General information

      Related sites

      Feedback

      Subscription

      Recent activity

      Clear Turn Off Turn On

      Your browsing activity is empty.

      Activity recording is turned off.

      Turn recording back on

      See more...