My NCBISign In

Display Settings:

Format

Send to:

Choose Destination

    URM1 ubiquitin related modifier 1 [ Homo sapiens ]

    Gene ID: 81605, updated on 19-May-2012
    Help top of page

    Summary

    Official Symbol
    URM1provided by HGNC
    Official Full Name
    ubiquitin related modifier 1provided by HGNC
    Primary source
    HGNC:28378
    Locus tag
    RP11-339B21.4
    See related
    Ensembl:ENSG00000167118; HPRD:12976; MIM:612693; Vega:OTTHUMG00000020742
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C9orf74; MGC2668; RP11-339B21.4
    Help top of page

    Genomic context

    Location :
    9q34.11
    Sequence :
    Chromosome: 9; NC_000009.11 (131133598..131153015)
    See URM1 in Epigenomics, MapViewer

    Chromosome 9 - NC_000009.11Genomic Context describing neighboring genes Neighboring gene coenzyme Q4 homolog (S. cerevisiae) Neighboring gene solute carrier family 27 (fatty acid transporter), member 4 Neighboring gene thymosin beta 4, X-linked pseudogene 4 Neighboring gene microRNA 219-2 Neighboring gene microRNA 2964a Neighboring gene uncharacterized LOC100506065

    Help top of page

    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
    Helptop of page

    Bibliography

    Related articles in PubMed

    1. Urm1 couples sulfur transfer to ubiquitin-like protein function in oxidative stress. Petroski MD, et al. Proc Natl Acad Sci U S A, 2011 Feb 1. PMID 21245332.
    2. Role of the ubiquitin-like protein Urm1 as a noncanonical lysine-directed protein modifier. Van der Veen AG, et al. Proc Natl Acad Sci U S A, 2011 Feb 1. PMID 21209336.
    3. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048.
    4. A functional proteomics approach links the ubiquitin-related modifier Urm1 to a tRNA modification pathway. Schlieker CD, et al. Proc Natl Acad Sci U S A, 2008 Nov 25. PMID 19017811.
    5. The sulfurtransferase activity of Uba4 presents a link between ubiquitin-like protein conjugation and activation of sulfur carrier proteins. Schmitz J, et al. Biochemistry, 2008 Jun 17. PMID 18491921.

    See all (12) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. observations suggest that Urm1 activation is more similar to that of a prokaryotic sulfur carrier protein than that of a ubiquitin-like protein
      Title: Urm1 couples sulfur transfer to ubiquitin-like protein function in oxidative stress.
    2. Urm1 has a conserved dual role by integrating the functions of prokaryotic sulfur carriers with those of eukaryotic protein modifiers of the Ub family
      Title: Role of the ubiquitin-like protein Urm1 as a noncanonical lysine-directed protein modifier.
    3. Urm1 is activated by an unusual mechanism to yield a thiocarboxylate intermediate that serves as sulfur donor in tRNA thiolation reactions
      Title: A functional proteomics approach links the ubiquitin-related modifier Urm1 to a tRNA modification pathway.
    4. The UBA4-URM1 system represents the evolutionary link between protein conjugation and protein modification by sulfur carrier proteins.
      Title: The sulfurtransferase activity of Uba4 presents a link between ubiquitin-like protein conjugation and activation of sulfur carrier proteins.
    Submit: New GeneRIF Correction
    Help top of page

    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Help top of page

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q9BTM9 Q9H1I8 ASCC2    HPRD  PubMed  
    Q9BTM9 P21127 CDK11B    HPRD  PubMed  
    Q9BTM9 Q12788 TBL3    HPRD  PubMed  
    BioGRID:123542 BioGRID:123921 ASCC2    BioGRID  PubMed Two-hybrid 
    BioGRID:123542 BioGRID:36544 UBA4    BioGRID  PubMed Reconstituted Complex 
    BioGRID:123542 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    Help top of page

    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Sulfur relay system, organism-specific biosystem (from KEGG)
      Sulfur relay system, organism-specific biosystemUbiquitin and ubiquitin-like proteins (Ubls) are signalling messengers that control many cellular functions, such as cell proliferation, apoptosis, and DNA repair. It is suggested that Ub-protein mod...
    • Sulfur relay system, conserved biosystem (from KEGG)
      Sulfur relay system, conserved biosystemUbiquitin and ubiquitin-like proteins (Ubls) are signalling messengers that control many cellular functions, such as cell proliferation, apoptosis, and DNA repair. It is suggested that Ub-protein mod...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    contributes_to sulfurtransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    tRNA thio-modification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    tRNA wobble uridine modification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytosol IC
    Inferred by Curator
    more info
    		 PubMed 
    Help top of page

    General protein information

    Preferred Names
    ubiquitin-related modifier 1 homolog
    Names
    ubiquitin-related modifier 1 homolog
    ubiquitin related modifier 1 homolog
    Help top of page

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001135947.2 → NP_001129419.1  ubiquitin-related modifier 1 homolog isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) encodes the longest isoform (B)
      Source sequence(s)
      AK300877, AL359091, BI823604
      Consensus CDS
      CCDS48035.1
      UniProtKB/Swiss-Prot
      Q9BTM9
      Related
      ENSP00000412922, ENST00000452446
      Conserved Domains (1) summary
      cl00155
      Location:7 – 79
      Blast Score: 229
      UBQ; Ubiquitin-like proteins

    2. NM_001265582.1 → NP_001252511.1  ubiquitin-related modifier 1 homolog isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has an additional segment in the 3' end, compared to variant 2, which reults in a protein (isoform C) with a shorter C-terminus, compared to isoform B.
      Source sequence(s)
      AL359091, BC011620, BI823604

    3. NM_030914.3 → NP_112176.1  ubiquitin-related modifier 1 homolog isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) lacks a segment in the 3' coding region, compared to variant 2, which results in a protein (isoform 1) with a distinct C-terminus, compared to isoform 2.
      Source sequence(s)
      AL359091, BC003581, BI823604
      Consensus CDS
      CCDS6900.1
      UniProtKB/Swiss-Prot
      Q9BTM9
      Related
      ENSP00000361944, OTTHUMP00000022258, ENST00000372853, OTTHUMT00000054422
      Conserved Domains (1) summary
      cd01764
      Location:7 – 101
      Blast Score: 311
      Urm1; Urm1-like ubuitin domain

    RNA

    1. NR_049743.1 RNA Sequence

      Description
      Transcript Variant: This variant (4) uses an alternate splice site in the 5' coding region, compared to variant 2, which results in a frameshift and early stop codon. The transcript is sufficiently abundant to represent as a RefSeq record; however, the predicted protein is not represented because the product is significiantly truncated and the transcript is a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AL359091, BI823604, DA691216

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000009.11 Reference GRCh37.p5 Primary Assembly

      Range
      131133598..131153015
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000141.1 Alternate HuRef

      Range
      100746421..100765838
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL359091.10 CAI13491.1
      CAI13492.1
      CAI13493.1
    genomic CH471090.1 EAW87782.1
      EAW87783.1
      EAW87784.1
      EAW87785.1
      EAW87786.1
    mRNA AI872337.1 None
    mRNA AK001880.1 BAG50985.1
    mRNA AK097029.1 None
    mRNA AK300877.1 BAG62520.1
    mRNA BC003581.1 AAH03581.1
    mRNA BC011620.2 None
    mRNA BI823604.1 None
    mRNA D83200.1 None
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9BTM9.1 GenPept UniProtKB/Swiss-Prot:Q9BTM9
    Help top of page

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Links

      Links to other resources

      General information

      Related sites

      Feedback

      Subscription

      Recent activity

      Clear Turn Off Turn On

      Your browsing activity is empty.

      Activity recording is turned off.

      Turn recording back on

      See more...