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TRIM8 tripartite motif containing 8 [ Homo sapiens (human) ]

Gene ID: 81603, updated on 8-May-2016
Official Symbol
TRIM8provided by HGNC
Official Full Name
tripartite motif containing 8provided by HGNC
Primary source
HGNC:HGNC:15579
See related
Ensembl:ENSG00000171206 HPRD:06934; MIM:606125; Vega:OTTHUMG00000018964
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GERP; RNF27
Summary
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to nuclear bodies. Its structure is similar to some tumor suppressor proteins and its gene maps to a locus thought to contain tumor suppressor genes. [provided by RefSeq, Jul 2008]
Orthologs
Location:
10q24.3
Exon count:
6
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 10 NC_000010.11 (102642903..102658319)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (104403326..104418076)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene major facilitator superfamily domain containing 13A Neighboring gene ARP1 actin-related protein 1 homolog A, centractin alpha Neighboring gene SUFU negative regulator of hedgehog signaling Neighboring gene ribosomal protein L23a pseudogene 58 Neighboring gene uncharacterized LOC105378460 Neighboring gene ADP ribosylation factor like GTPase 3 Neighboring gene sideroflexin 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Biological insights from 108 schizophrenia-associated genetic loci.
NHGRI GWA Catalog
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
NHGRI GWA Catalog

Replication interactions

Interaction Pubs
Knockdown of tripartite motif containing 8 (TRIM8) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

  • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
    Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Interferon Signaling, organism-specific biosystem (from REACTOME)
    Interferon Signaling, organism-specific biosystemInterferons (IFNs) are cytokines that play a central role in initiating immune responses, especially antiviral and antitumor effects. There are three types of IFNs:Type I (IFN-alpha, -beta and others...
  • Interferon gamma signaling, organism-specific biosystem (from REACTOME)
    Interferon gamma signaling, organism-specific biosystemInterferon-gamma (IFN-gamma) belongs to the type II interferon family and is secreted by activated immune cells-primarily T and NK cells, but also B-cells and APC. INFG exerts its effect on cells by ...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ligase activity IEA
Inferred from Electronic Annotation
more info
 
protein homodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
zinc ion binding NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
PML body IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
Preferred Names
probable E3 ubiquitin-protein ligase TRIM8
Names
glioblastoma expressed ring finger protein
glioblastoma-expressed RING finger protein
ring finger protein 27
tripartite motif protein TRIM8
tripartite motif-containing 8
tripartite motif-containing protein 8

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030912.2NP_112174.2  probable E3 ubiquitin-protein ligase TRIM8

    See identical proteins and their annotated locations for NP_112174.2

    Status: VALIDATED

    Source sequence(s)
    AA907931, AF220034, BG746631
    Consensus CDS
    CCDS31274.1
    UniProtKB/Swiss-Prot
    Q9BZR9
    Related
    ENSP00000302120, OTTHUMP00000020372, ENST00000302424, OTTHUMT00000050084
    Conserved Domains (3) summary
    cd00162
    Location:1557
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    pfam00643
    Location:140182
    zf-B_box; B-box zinc finger
    pfam12998
    Location:183256
    ING; Inhibitor of growth proteins N-terminal histone-binding

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p2 Primary Assembly

    Range
    102642903..102658319
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011540217.1XP_011538519.1  

    Conserved Domains (2) summary
    cd00162
    Location:1557
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    pfam00643
    Location:140182
    zf-B_box; B-box zinc finger
  2. XM_006717988.2XP_006718051.1  

    Conserved Domains (2) summary
    cd00162
    Location:1557
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    pfam12998
    Location:183256
    ING; Inhibitor of growth proteins N-terminal histone-binding

Alternate CHM1_1.1

Genomic

  1. NC_018921.2 Alternate CHM1_1.1

    Range
    104688022..104701849
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)