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CAMK2B calcium/calmodulin-dependent protein kinase II beta [ Homo sapiens (human) ]

Gene ID: 816, updated on 12-Apr-2014
Official Symbol
CAMK2Bprovided by HGNC
Official Full Name
calcium/calmodulin-dependent protein kinase II betaprovided by HGNC
Primary source
HGNC:1461
See related
Ensembl:ENSG00000058404; HPRD:12127; MIM:607707; Vega:OTTHUMG00000023491
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CAM2; CAMK2; CAMKB
Summary
The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a beta chain. It is possible that distinct isoforms of this chain have different cellular localizations and interact differently with calmodulin. Eight transcript variants encoding eight distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Location :
7p14.3-p14.1
Sequence :
Chromosome: 7; NC_000007.14 (44217150..44325631, complement)
See CAMK2B in Epigenomics, MapViewer

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene glucokinase (hexokinase 4) Neighboring gene YKT6 v-SNARE homolog (S. cerevisiae) Neighboring gene NudC domain containing 3 Neighboring gene ribosomal protein L32 pseudogene 18 Neighboring gene ribosomal protein L36a pseudogene 27

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
A meta-analysis of genome-wide association studies identifies novel variants associated with osteoarthritis of the hip.
NHGRI GWA Catalog
Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Tat, p14 tat Tat-induced IL-10 expression is regulated by p38 MAPK- and CaMK II-activated CREB-1 as well as Sp-1 transcription factors PubMed
tat HIV-1 Tat inhibits the activation of CAMKII elicited via LFA-1 in NK cells, providing evidence that Tat inhibits NK cell activation which might contribute to the impairment of natural immunity in HIV-1 infection PubMed
tat HIV-1 Tat inhibits the activation of CAMKII elicited via beta (3) integrin PubMed

Go to the HIV-1, Human Protein Interaction Database

  • Activation of NMDA receptor upon glutamate binding and postsynaptic events, organism-specific biosystem (from REACTOME)
    Activation of NMDA receptor upon glutamate binding and postsynaptic events, organism-specific biosystemNMDA receptors are a subtype of ionotropic glutamate receptors that are specifically activated by a glutamate agonist N-methyl-D-aspartate (NMDA). Activation of NMDA receptor involves opening of the ...
  • Adrenergic signaling in cardiomyocytes, organism-specific biosystem (from KEGG)
    Adrenergic signaling in cardiomyocytes, organism-specific biosystemCardiac myocytes express at least six subtypes of adrenergic receptor (AR) which include three subtypes of beta-AR (beta-1, beta-2, beta-3) and three subtypes of the alpha-1-AR (alpha-1A, alpha-1B, a...
  • Adrenergic signaling in cardiomyocytes, conserved biosystem (from KEGG)
    Adrenergic signaling in cardiomyocytes, conserved biosystemCardiac myocytes express at least six subtypes of adrenergic receptor (AR) which include three subtypes of beta-AR (beta-1, beta-2, beta-3) and three subtypes of the alpha-1-AR (alpha-1A, alpha-1B, a...
  • Amphetamine addiction, organism-specific biosystem (from KEGG)
    Amphetamine addiction, organism-specific biosystemAmphetamine is a psychostimulant drug that exerts persistent addictive effects. Most addictive drugs increase extracellular concentrations of dopamine (DA) in nucleus accumbens (NAc) and medial prefr...
  • Amphetamine addiction, conserved biosystem (from KEGG)
    Amphetamine addiction, conserved biosystemAmphetamine is a psychostimulant drug that exerts persistent addictive effects. Most addictive drugs increase extracellular concentrations of dopamine (DA) in nucleus accumbens (NAc) and medial prefr...
  • CREB phosphorylation through the activation of CaMKII, organism-specific biosystem (from REACTOME)
    CREB phosphorylation through the activation of CaMKII, organism-specific biosystemCa2+ signal generated through NMDA receptor in the post-synaptic neuron activates adenylate cyclase signal transduction, leading to the activation of PKA and phosphorylation and activation of CREB-in...
  • CREB phosphorylation through the activation of Ras, organism-specific biosystem (from REACTOME)
    CREB phosphorylation through the activation of Ras, organism-specific biosystemCa2+ influx through the NMDA receptor initiates subsequent molecular pathways that have a defined role in establishing long-lasting synaptic changes. The molecular signaling initiated by a rise in Ca...
  • Calcium Regulation in the Cardiac Cell, organism-specific biosystem (from WikiPathways)
    Calcium Regulation in the Cardiac Cell, organism-specific biosystemCalcium is a common signaling mechanism, as once it enters the cytoplasm it exerts allosteric regulatory affects on many enzymes and proteins. Calcium can act in signal transduction after influx resu...
  • Calcium signaling pathway, organism-specific biosystem (from KEGG)
    Calcium signaling pathway, organism-specific biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
  • Calcium signaling pathway, conserved biosystem (from KEGG)
    Calcium signaling pathway, conserved biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
  • Cholinergic synapse, organism-specific biosystem (from KEGG)
    Cholinergic synapse, organism-specific biosystemAcetylcholine (ACh) is a neurotransmitter widely distributed in the central (and also peripheral, autonomic and enteric) nervous system (CNS). In the CNS, ACh facilitates many functions, such as lear...
  • Circadian entrainment, organism-specific biosystem (from KEGG)
    Circadian entrainment, organism-specific biosystemCircadian entrainment is a fundamental property by which the period of the internal biological clock is entrained by recurring exogenous signals, such that the organism's endocrine and behavioral rhy...
  • Circadian entrainment, conserved biosystem (from KEGG)
    Circadian entrainment, conserved biosystemCircadian entrainment is a fundamental property by which the period of the internal biological clock is entrained by recurring exogenous signals, such that the organism's endocrine and behavioral rhy...
  • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
    Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
  • Dopaminergic synapse, organism-specific biosystem (from KEGG)
    Dopaminergic synapse, organism-specific biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
  • Dopaminergic synapse, conserved biosystem (from KEGG)
    Dopaminergic synapse, conserved biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
  • ErbB signaling pathway, organism-specific biosystem (from KEGG)
    ErbB signaling pathway, organism-specific biosystemThe ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including prolife...
  • ErbB signaling pathway, conserved biosystem (from KEGG)
    ErbB signaling pathway, conserved biosystemThe ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including prolife...
  • Gastric acid secretion, organism-specific biosystem (from KEGG)
    Gastric acid secretion, organism-specific biosystemGastric acid is a key factor in normal upper gastrointestinal functions, including protein digestion and calcium and iron absorption, as well as providing some protection against bacterial infections...
  • Gastric acid secretion, conserved biosystem (from KEGG)
    Gastric acid secretion, conserved biosystemGastric acid is a key factor in normal upper gastrointestinal functions, including protein digestion and calcium and iron absorption, as well as providing some protection against bacterial infections...
  • Glioma, organism-specific biosystem (from KEGG)
    Glioma, organism-specific biosystemGliomas are the most common of the primary brain tumors and account for more than 40% of all central nervous system neoplasms. Gliomas include tumours that are composed predominantly of astrocytes (a...
  • Glioma, conserved biosystem (from KEGG)
    Glioma, conserved biosystemGliomas are the most common of the primary brain tumors and account for more than 40% of all central nervous system neoplasms. Gliomas include tumours that are composed predominantly of astrocytes (a...
  • Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity, organism-specific biosystem (from REACTOME)
    Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity, organism-specific biosystemExcitatory synaptic transmission in the brain is carried out by glutamate receptors through the activation of both ionotropic and metabotropic receptors. Ionotropic glutamate receptors are of three ...
  • GnRH signaling pathway, organism-specific biosystem (from KEGG)
    GnRH signaling pathway, organism-specific biosystemGonadotropin-releasing hormone (GnRH) secretion from the hypothalamus acts upon its receptor in the anterior pituitary to regulate the production and release of the gonadotropins, LH and FSH. The GnR...
  • GnRH signaling pathway, conserved biosystem (from KEGG)
    GnRH signaling pathway, conserved biosystemGonadotropin-releasing hormone (GnRH) secretion from the hypothalamus acts upon its receptor in the anterior pituitary to regulate the production and release of the gonadotropins, LH and FSH. The GnR...
  • HIF-1 signaling pathway, organism-specific biosystem (from KEGG)
    HIF-1 signaling pathway, organism-specific biosystemHypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostasis. It consists of two subunits: an inducibly-expressed HIF-1alpha subunit and a c...
  • Hypothetical Network for Drug Addiction, organism-specific biosystem (from WikiPathways)
    Hypothetical Network for Drug Addiction, organism-specific biosystemAdapted from figure 2 in [http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.0040002 Li et al.].
  • IFN-gamma pathway, organism-specific biosystem (from Pathway Interaction Database)
    IFN-gamma pathway, organism-specific biosystem
    IFN-gamma pathway
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Inflammatory mediator regulation of TRP channels, organism-specific biosystem (from KEGG)
    Inflammatory mediator regulation of TRP channels, organism-specific biosystemThe TRP channels that exhibit a unique response to temperature have been given the name thermo-TRPs. Among all thermo- TRP channels, TRPV1-4, TRPM8, and TRPA1 are expressed in subsets of nociceptive...
  • Inflammatory mediator regulation of TRP channels, conserved biosystem (from KEGG)
    Inflammatory mediator regulation of TRP channels, conserved biosystemThe TRP channels that exhibit a unique response to temperature have been given the name thermo-TRPs. Among all thermo- TRP channels, TRPV1-4, TRPM8, and TRPA1 are expressed in subsets of nociceptive...
  • Insulin secretion, organism-specific biosystem (from KEGG)
    Insulin secretion, organism-specific biosystemPancreatic beta cells are specialised endocrine cells that continuously sense the levels of blood sugar and other fuels and, in response, secrete insulin to maintain normal fuel homeostasis. Glucose-...
  • Interferon Signaling, organism-specific biosystem (from REACTOME)
    Interferon Signaling, organism-specific biosystemInterferons (IFNs) are cytokines that play a central role in initiating immune responses, especially antiviral and antitumor effects. There are three types of IFNs:Type I (IFN-alpha, -beta and others...
  • Interferon gamma signaling, organism-specific biosystem (from REACTOME)
    Interferon gamma signaling, organism-specific biosystemInterferon-gamma (IFN-gamma) belongs to the type II interferon family and is secreted by activated immune cells-primarily T and NK cells, but also B-cells and APC. INFG exerts its effect on cells by ...
  • Long-term potentiation, organism-specific biosystem (from KEGG)
    Long-term potentiation, organism-specific biosystemHippocampal long-term potentiation (LTP), a long-lasting increase in synaptic efficacy, is the molecular basis for learning and memory. Tetanic stimulation of afferents in the CA1 region of the hippo...
  • Long-term potentiation, conserved biosystem (from KEGG)
    Long-term potentiation, conserved biosystemHippocampal long-term potentiation (LTP), a long-lasting increase in synaptic efficacy, is the molecular basis for learning and memory. Tetanic stimulation of afferents in the CA1 region of the hippo...
  • Melanogenesis, organism-specific biosystem (from KEGG)
    Melanogenesis, organism-specific biosystemCutaneous melanin pigment plays a critical role in camouflage, mimicry, social communication, and protection against harmful effects of solar radiation. Melanogenesis is under complex regulatory cont...
  • Melanogenesis, conserved biosystem (from KEGG)
    Melanogenesis, conserved biosystemCutaneous melanin pigment plays a critical role in camouflage, mimicry, social communication, and protection against harmful effects of solar radiation. Melanogenesis is under complex regulatory cont...
  • Myometrial Relaxation and Contraction Pathways, organism-specific biosystem (from WikiPathways)
    Myometrial Relaxation and Contraction Pathways, organism-specific biosystemThis pathway illustrates signaling networks implicated in uterine muscle contraction at labor and quiescence throughout gestation (pregnancy). The muscle of the uterus, responsible for contractile ac...
  • Neuronal System, organism-specific biosystem (from REACTOME)
    Neuronal System, organism-specific biosystemThe human brain contains at least 100 billion neurons, each with the ability to influence many other cells. Clearly, highly sophisticated and efficient mechanisms are needed to enable communication a...
  • Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell, organism-specific biosystem (from REACTOME)
    Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell, organism-specific biosystemThe neurotransmitter in the synaptic cleft released by the pre-synaptic neuron binds specific receptors located on the post-synaptic terminal. These receptors are either ion channels or G protein cou...
  • Neurotrophin signaling pathway, organism-specific biosystem (from KEGG)
    Neurotrophin signaling pathway, organism-specific biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
  • Neurotrophin signaling pathway, conserved biosystem (from KEGG)
    Neurotrophin signaling pathway, conserved biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
  • Olfactory transduction, organism-specific biosystem (from KEGG)
    Olfactory transduction, organism-specific biosystemWithin the compact cilia of the olfactory receptor neurons (ORNs) a cascade of enzymatic activity transduces the binding of an odorant molecule to a receptor into an electrical signal that can be tra...
  • Olfactory transduction, conserved biosystem (from KEGG)
    Olfactory transduction, conserved biosystemWithin the compact cilia of the olfactory receptor neurons (ORNs) a cascade of enzymatic activity transduces the binding of an odorant molecule to a receptor into an electrical signal that can be tra...
  • Oocyte meiosis, organism-specific biosystem (from KEGG)
    Oocyte meiosis, organism-specific biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, homologous chromosomes recombine and then segrega...
  • Oocyte meiosis, conserved biosystem (from KEGG)
    Oocyte meiosis, conserved biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, homologous chromosomes recombine and then segrega...
  • Post NMDA receptor activation events, organism-specific biosystem (from REACTOME)
    Post NMDA receptor activation events, organism-specific biosystemCa2+ influx through the NMDA receptor initiates subsequent molecular pathways that have a defined role in establishing long-lasting synaptic changes. The molecular signaling initiated by a rise in Ca...
  • Proteoglycans in cancer, organism-specific biosystem (from KEGG)
    Proteoglycans in cancer, organism-specific biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
  • Proteoglycans in cancer, conserved biosystem (from KEGG)
    Proteoglycans in cancer, conserved biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
  • Ras activation uopn Ca2+ infux through NMDA receptor, organism-specific biosystem (from REACTOME)
    Ras activation uopn Ca2+ infux through NMDA receptor, organism-specific biosystemCa2+ influx through the NMDA receptor leads to the activation of Ras kinase via the activation of RasGRF.
  • TGF-beta Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
    TGF-beta Receptor Signaling Pathway, organism-specific biosystem"The TGF beta receptors TGFBR1 and TGFBR2 belong to a subfamily of membrane-bound serine/threonine kinases which are designated as Type I or II based on their structural and functional properties. Th...
  • Trafficking of AMPA receptors, organism-specific biosystem (from REACTOME)
    Trafficking of AMPA receptors, organism-specific biosystemRepetitive presynaptic activity causes long lasting changes in the postsynaptic transmission by changing the type and the number of AMPA receptors. These changes are brought about by trafficking mec...
  • Transmission across Chemical Synapses, organism-specific biosystem (from REACTOME)
    Transmission across Chemical Synapses, organism-specific biosystemChemical synapses are specialized junctions that are used for communication between neurons, neurons and muscle or gland cells. The synapse involves a pre-synaptic neuron and a post-synaptic neuron,...
  • Tuberculosis, organism-specific biosystem (from KEGG)
    Tuberculosis, organism-specific biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
  • Tuberculosis, conserved biosystem (from KEGG)
    Tuberculosis, conserved biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
  • Unblocking of NMDA receptor, glutamate binding and activation, organism-specific biosystem (from REACTOME)
    Unblocking of NMDA receptor, glutamate binding and activation, organism-specific biosystemAt resting membrane potential the NMDA receptor is blocked by extracellular Mg2+ ions and therefore is not activated in this state by ligands (glutamate, glycine, NMDA). The voltage block is removed ...
  • Wnt Signaling Pathway NetPath, organism-specific biosystem (from WikiPathways)
    Wnt Signaling Pathway NetPath, organism-specific biosystemWnt family of proteins are a large family of cysteine-rich secreted glycoproteins that regulate cell-cell interactions. They bind to members of the Frizzled family of 7 transmembrane receptors. Bindi...
  • Wnt signaling pathway, organism-specific biosystem (from KEGG)
    Wnt signaling pathway, organism-specific biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
  • Wnt signaling pathway, conserved biosystem (from KEGG)
    Wnt signaling pathway, conserved biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
  • p38 MAPK signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
    p38 MAPK signaling pathway, organism-specific biosystem
    p38 MAPK signaling pathway
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
actin binding IEA
Inferred from Electronic Annotation
more info
 
calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
calmodulin-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G1/S transition of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
activation of meiosis involved in egg activation IEA
Inferred from Electronic Annotation
more info
 
calcium ion transport IEA
Inferred from Electronic Annotation
more info
 
cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
 
inhibitory G-protein coupled receptor phosphorylation IEA
Inferred from Electronic Annotation
more info
 
interferon-gamma-mediated signaling pathway TAS
Traceable Author Statement
more info
 
neuromuscular process controlling balance IEA
Inferred from Electronic Annotation
more info
 
peptidyl-serine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of dendritic spine morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of neuron projection development ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of synapse maturation ISS
Inferred from Sequence or Structural Similarity
more info
 
protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation TAS
Traceable Author Statement
more info
PubMed 
regulation of calcium ion transport TAS
Traceable Author Statement
more info
PubMed 
regulation of dendritic spine development TAS
Traceable Author Statement
more info
PubMed 
regulation of long-term neuronal synaptic plasticity TAS
Traceable Author Statement
more info
PubMed 
regulation of skeletal muscle adaptation TAS
Traceable Author Statement
more info
PubMed 
regulation of synapse structural plasticity TAS
Traceable Author Statement
more info
PubMed 
regulation of synaptic transmission, cholinergic IEA
Inferred from Electronic Annotation
more info
 
response to cadmium ion IEA
Inferred from Electronic Annotation
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
synaptic transmission TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
endocytic vesicle membrane TAS
Traceable Author Statement
more info
 
microtubule organizing center IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
sarcoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
spindle midzone IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
calcium/calmodulin-dependent protein kinase type II subunit beta
Names
calcium/calmodulin-dependent protein kinase type II subunit beta
caMK-II subunit beta
CaM-kinase II beta chain
CaM kinase II beta subunit
proline rich calmodulin-dependent protein kinase
NP_001211.3
NP_742075.1
NP_742076.1
NP_742077.1
NP_742078.1
NP_742079.1
NP_742080.1
NP_742081.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029407.1 RefSeqGene

    Range
    5001..113482
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001220.4NP_001211.3  calcium/calmodulin-dependent protein kinase type II subunit beta isoform 1

    See proteins identical to NP_001211.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC006454, AK290148, BI550751, U23460
    Consensus CDS
    CCDS5483.1
    UniProtKB/TrEMBL
    A4D2J9
    UniProtKB/Swiss-Prot
    Q13554
    Related
    ENSP00000379098, OTTHUMP00000159355, ENST00000395749, OTTHUMT00000251138
    Conserved Domains (4) summary
    cd05123
    Location:20271
    Blast Score: 603
    STKc_AGC; Catalytic domain of AGC family Protein Serine/Threonine Kinases
    smart00220
    Location:14272
    Blast Score: 863
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam08332
    Location:534661
    Blast Score: 600
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II Association
    pfam15552
    Location:420504
    Blast Score: 89
    DUF4657; Domain of unknown function (DUF4657)
  2. NM_172078.2NP_742075.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform 2

    See proteins identical to NP_742075.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame segment of the coding region, compared to variant 1. It encodes a shorter isoform (2) that is missing an internal segment compared to isoform 1.
    Source sequence(s)
    AC006454, AF078803, AK290148, BI550751
    Consensus CDS
    CCDS5484.1
    UniProtKB/Swiss-Prot
    Q13554
    Conserved Domains (3) summary
    cd05123
    Location:20271
    Blast Score: 599
    STKc_AGC; Catalytic domain of AGC family Protein Serine/Threonine Kinases
    smart00220
    Location:14272
    Blast Score: 862
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam08332
    Location:410537
    Blast Score: 591
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II Association
  3. NM_172079.2NP_742076.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform 3

    See proteins identical to NP_742076.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), also known as beta 4, lacks an in-frame segment of the coding region, compared to variant 1. It encodes a shorter isoform (3), also known as beta 4 subunit, that is missing an internal segment compared to isoform 1.
    Source sequence(s)
    AC006454, AJ252238, AK290148, BI550751, BX445032, DB566810
    Consensus CDS
    CCDS5485.1
    UniProtKB/Swiss-Prot
    Q13554
    Related
    ENSP00000390292, ENST00000457475
    Conserved Domains (3) summary
    cd05123
    Location:20271
    Blast Score: 596
    STKc_AGC; Catalytic domain of AGC family Protein Serine/Threonine Kinases
    smart00220
    Location:14272
    Blast Score: 856
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam08332
    Location:386513
    Blast Score: 590
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II Association
  4. NM_172080.2NP_742077.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform 4

    See proteins identical to NP_742077.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4), also known as beta e, lacks an in-frame segment of the coding region, compared to variant 1. It encodes a shorter isoform (4), also known as beta e subunit, that is missing an internal segment compared to isoform 1.
    Source sequence(s)
    AC006454, AF083419, AK290148, BI550751
    Consensus CDS
    CCDS43573.1
    UniProtKB/Swiss-Prot
    Q13554
    Conserved Domains (3) summary
    cd05123
    Location:20271
    Blast Score: 596
    STKc_AGC; Catalytic domain of AGC family Protein Serine/Threonine Kinases
    smart00220
    Location:14272
    Blast Score: 855
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam08332
    Location:385512
    Blast Score: 590
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II Association
  5. NM_172081.2NP_742078.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform 5

    See proteins identical to NP_742078.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5), also known as beta e', lacks an in-frame segment of the coding region, compared to variant 1. It encodes a shorter isoform (5), also known as beta e' subunit, that is missing an internal segment compared to isoform 1.
    Source sequence(s)
    AC006454, AK290148, BC019070, BI550751
    Consensus CDS
    CCDS5486.1
    UniProtKB/Swiss-Prot
    Q13554
    Conserved Domains (3) summary
    cd05123
    Location:20271
    Blast Score: 595
    STKc_AGC; Catalytic domain of AGC family Protein Serine/Threonine Kinases
    smart00220
    Location:14272
    Blast Score: 856
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam08332
    Location:371498
    Blast Score: 590
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II Association
  6. NM_172082.2NP_742079.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform 6

    See proteins identical to NP_742079.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6), also known as beta 6, lacks an in-frame segment of the coding region, compared to variant 1. It encodes a shorter isoform (6), also known as beta 6 subunit, that is missing an internal segment compared to isoform 1.
    Source sequence(s)
    AC006454, AF081924, AK290148, BI550751
    Consensus CDS
    CCDS5487.1
    UniProtKB/Swiss-Prot
    Q13554
    Conserved Domains (3) summary
    cd05123
    Location:20271
    Blast Score: 596
    STKc_AGC; Catalytic domain of AGC family Protein Serine/Threonine Kinases
    smart00220
    Location:14272
    Blast Score: 856
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl17504
    Location:386487
    Blast Score: 423
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II Association
  7. NM_172083.2NP_742080.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform 7

    See proteins identical to NP_742080.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7), also known as beta 2, lacks an in-frame segment of the coding region, compared to variant 1. It encodes a shorter isoform (7), also known as beta 2 subunit, that is missing an internal segment compared to isoform 1.
    Source sequence(s)
    AA399393, AC006454, AJ252236, AK290148, BI550751, DA069361, DB175099
    Consensus CDS
    CCDS5488.1
    UniProtKB/Swiss-Prot
    Q13554
    Conserved Domains (3) summary
    cd05123
    Location:20271
    Blast Score: 591
    STKc_AGC; Catalytic domain of AGC family Protein Serine/Threonine Kinases
    smart00220
    Location:14272
    Blast Score: 848
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam08332
    Location:347474
    Blast Score: 588
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II Association
  8. NM_172084.2NP_742081.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform 8

    See proteins identical to NP_742081.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8), also known as beta 7, lacks an in-frame segment of the coding region, compared to variant 1. It encodes a shorter isoform (8), also known as beta 7 subunit, that is missing an internal segment compared to isoform 1.
    Source sequence(s)
    AC006454, AK290148, BI550751, BX445032, DB566810
    Consensus CDS
    CCDS5489.1
    UniProtKB/Swiss-Prot
    Q13554
    Conserved Domains (3) summary
    cd05123
    Location:20271
    Blast Score: 589
    STKc_AGC; Catalytic domain of AGC family Protein Serine/Threonine Kinases
    smart00220
    Location:14272
    Blast Score: 844
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam08332
    Location:317444
    Blast Score: 586
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II Association

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000007.14

    Range
    44217150..44325631, complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005249861.1XP_005249918.1  

    See proteins identical to XP_005249918.1

    UniProtKB/Swiss-Prot
    Q13554
    Related
    ENSP00000326375, OTTHUMP00000209343, ENST00000350811, OTTHUMT00000343339
    Conserved Domains (3) summary
    cd05123
    Location:20271
    Blast Score: 599
    STKc_AGC; Catalytic domain of AGC family Protein Serine/Threonine Kinases
    smart00220
    Location:14272
    Blast Score: 862
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam08332
    Location:410537
    Blast Score: 591
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II Association
  2. XM_006715776.1XP_006715839.1  

    See proteins identical to XP_006715839.1

    Conserved Domains (4) summary
    cd05123
    Location:20271
    Blast Score: 603
    STKc_AGC; Catalytic domain of AGC family Protein Serine/Threonine Kinases
    smart00220
    Location:14272
    Blast Score: 863
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam08332
    Location:534661
    Blast Score: 600
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II Association
    pfam15552
    Location:420504
    Blast Score: 89
    DUF4657; Domain of unknown function (DUF4657)
  3. XM_006715783.1XP_006715846.1  

    Conserved Domains (4) summary
    cd05123
    Location:20271
    Blast Score: 603
    STKc_AGC; Catalytic domain of AGC family Protein Serine/Threonine Kinases
    smart00220
    Location:14272
    Blast Score: 863
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam08332
    Location:485612
    Blast Score: 600
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II Association
    pfam15552
    Location:371455
    Blast Score: 90
    DUF4657; Domain of unknown function (DUF4657)
  4. XM_006715781.1XP_006715844.1  

    Conserved Domains (4) summary
    cd05123
    Location:20271
    Blast Score: 603
    STKc_AGC; Catalytic domain of AGC family Protein Serine/Threonine Kinases
    smart00220
    Location:14272
    Blast Score: 863
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam08332
    Location:494621
    Blast Score: 600
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II Association
    pfam15552
    Location:380464
    Blast Score: 89
    DUF4657; Domain of unknown function (DUF4657)
  5. XM_006715779.1XP_006715842.1  

    Conserved Domains (4) summary
    cd05123
    Location:20271
    Blast Score: 603
    STKc_AGC; Catalytic domain of AGC family Protein Serine/Threonine Kinases
    smart00220
    Location:14272
    Blast Score: 863
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam08332
    Location:509636
    Blast Score: 600
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II Association
    pfam15552
    Location:395479
    Blast Score: 89
    DUF4657; Domain of unknown function (DUF4657)
  6. XM_005249864.2XP_005249921.1  

    Conserved Domains (3) summary
    cd05123
    Location:20271
    Blast Score: 592
    STKc_AGC; Catalytic domain of AGC family Protein Serine/Threonine Kinases
    smart00220
    Location:14272
    Blast Score: 848
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam08332
    Location:362489
    Blast Score: 588
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II Association
  7. XM_005249859.2XP_005249916.1  

    Conserved Domains (4) summary
    cd05123
    Location:20271
    Blast Score: 603
    STKc_AGC; Catalytic domain of AGC family Protein Serine/Threonine Kinases
    smart00220
    Location:14272
    Blast Score: 863
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam08332
    Location:510637
    Blast Score: 600
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II Association
    pfam15552
    Location:396480
    Blast Score: 89
    DUF4657; Domain of unknown function (DUF4657)
  8. XM_006715784.1XP_006715847.1  

    Conserved Domains (3) summary
    cd05123
    Location:20271
    Blast Score: 595
    STKc_AGC; Catalytic domain of AGC family Protein Serine/Threonine Kinases
    smart00220
    Location:14272
    Blast Score: 855
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam08332
    Location:386513
    Blast Score: 589
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II Association
  9. XM_006715778.1XP_006715841.1  

    Conserved Domains (4) summary
    cd05123
    Location:20271
    Blast Score: 603
    STKc_AGC; Catalytic domain of AGC family Protein Serine/Threonine Kinases
    smart00220
    Location:14272
    Blast Score: 863
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam08332
    Location:510637
    Blast Score: 600
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II Association
    pfam15552
    Location:396480
    Blast Score: 90
    DUF4657; Domain of unknown function (DUF4657)
  10. XM_005249862.2XP_005249919.1  

    See proteins identical to XP_005249919.1

    Conserved Domains (3) summary
    cd05123
    Location:20271
    Blast Score: 599
    STKc_AGC; Catalytic domain of AGC family Protein Serine/Threonine Kinases
    smart00220
    Location:14272
    Blast Score: 862
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam08332
    Location:395522
    Blast Score: 591
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II Association
  11. XM_006715777.1XP_006715840.1  

    Conserved Domains (4) summary
    cd05123
    Location:20271
    Blast Score: 603
    STKc_AGC; Catalytic domain of AGC family Protein Serine/Threonine Kinases
    smart00220
    Location:14272
    Blast Score: 863
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam08332
    Location:519646
    Blast Score: 600
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II Association
    pfam15552
    Location:405489
    Blast Score: 89
    DUF4657; Domain of unknown function (DUF4657)
  12. XM_006715780.1XP_006715843.1  

    Conserved Domains (3) summary
    cd05123
    Location:20271
    Blast Score: 603
    STKc_AGC; Catalytic domain of AGC family Protein Serine/Threonine Kinases
    smart00220
    Location:14272
    Blast Score: 863
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam08332
    Location:496623
    Blast Score: 599
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II Association
  13. XM_006715782.1XP_006715845.1  

    Conserved Domains (3) summary
    cd05123
    Location:20271
    Blast Score: 603
    STKc_AGC; Catalytic domain of AGC family Protein Serine/Threonine Kinases
    smart00220
    Location:14272
    Blast Score: 863
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam08332
    Location:491618
    Blast Score: 598
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II Association

Alternate HuRef

Genomic

  1. AC_000139.1 Alternate HuRef

    Range
    44142028..44208379, complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018918.2 Alternate CHM1_1.1

    Range
    44260608..44369178, complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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