CLPB ClpB caseinolytic peptidase B homolog (E. coli) [Homo sapiens] - Gene

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Summary

Official Symbol: CLPBprovided by HGNC
Official Full Name: ClpB caseinolytic peptidase B homolog (E. coli)provided by HGNC
Primary source: HGNC:30664
See related: Ensembl:ENSG00000162129; HPRD:11560; Vega:OTTHUMG00000167902
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SKD3; HSP78; FLJ13152

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Genomic context

Location :: 11q13.4

Sequence :: Chromosome: 11; NC_000011.9 (72003469..72145568, complement)

See CLPB in Epigenomics, MapViewer

Chromosome 11 - NC_000011.9 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
formation of the DnaK-ClpB bichaperone network is a three step process
Title: DnaK-mediated association of ClpB to protein aggregates. A bichaperone network at the aggregate surface.
ClpB-DnaK reactivated all aggregated fusion proteins with similar efficiency, without unfolding native domains, demonstrating that partial threading of the misfolded moiety is sufficient to solubilize aggregates.
Title: Protein disaggregation by the AAA+ chaperone ClpB involves partial threading of looped polypeptide segments.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
Q9H078	O15198	SMAD9	HPRD	PubMed
Q9H078	Q9UNY4	TTF2	HPRD	PubMed
BioGRID:123531	BioGRID:116176	COPS6	BioGRID	PubMed	Affinity Capture-MS
BioGRID:123531	BioGRID:125385	OSBPL10	BioGRID	PubMed	Affinity Capture-MS
BioGRID:123531	BioGRID:112873	TERF2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:123531	BioGRID:114036	TTF2	BioGRID	PubMed	Two-hybrid
BioGRID:123531	BioGRID:113194	UCHL3	BioGRID	PubMed	Affinity Capture-MS
BioGRID:123531	BioGRID:124238	USP30	BioGRID	PubMed	Affinity Capture-MS

Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
molecular_function	ND No biological Data available more info
nucleoside-triphosphatase activity	IEA Inferred from Electronic Annotation more info
nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
cellular response to heat	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
cellular_component	ND No biological Data available more info
mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: caseinolytic peptidase B protein homolog

Names: caseinolytic peptidase B protein homolog; suppressor of potassium transport defect 3

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001258392.1 → NP_001245321.1 caseinolytic peptidase B protein homolog isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an exon in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.

Source sequence(s)

AK023214, BC006404, BU848809, DC396265

Conserved Domains (5) summary

cd00204
Location:132 – 285
Blast Score: 211

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd00009
Location:318 – 472
Blast Score: 173

AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...

smart00382
Location:343 – 480
Blast Score: 148

AAA; ATPases associated with a variety of cellular activities

pfam12796
Location:138 – 266
Blast Score: 170

Ank_2; Ankyrin repeats (3 copies)

cl11083
Location:543 – 621
Blast Score: 139

ClpB_D2-small; C-terminal, D2-small domain, of ClpB protein
NM_001258393.1 → NP_001245322.1 caseinolytic peptidase B protein homolog isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks two exons in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.

Source sequence(s)

AK302006, BC006404, DC396265

Conserved Domains (5) summary

cd00204
Location:132 – 256
Blast Score: 161

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd00009
Location:289 – 443
Blast Score: 173

AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...

smart00382
Location:314 – 451
Blast Score: 148

AAA; ATPases associated with a variety of cellular activities

pfam12796
Location:138 – 237
Blast Score: 149

Ank_2; Ankyrin repeats (3 copies)

cl11083
Location:514 – 592
Blast Score: 139

ClpB_D2-small; C-terminal, D2-small domain, of ClpB protein
NM_001258394.1 → NP_001245323.1 caseinolytic peptidase B protein homolog isoform 4

Status: VALIDATED

Description

Transcript Variant: This variant (4) contains an alternate exon in the 5' coding region and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (4) is shorter and has a distinct N-terminus, compared to isoform 1.

Source sequence(s)

AK302069, BC006404, DC396265

Conserved Domains (5) summary

cd00204
Location:116 – 270
Blast Score: 163

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd00009
Location:303 – 457
Blast Score: 176

AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...

smart00382
Location:328 – 465
Blast Score: 150

AAA; ATPases associated with a variety of cellular activities

pfam12796
Location:126 – 251
Blast Score: 131

Ank_2; Ankyrin repeats (3 copies)

cl11083
Location:530 – 615
Blast Score: 140

ClpB_D2-small; C-terminal, D2-small domain, of ClpB protein
NM_030813.4 → NP_110440.1 caseinolytic peptidase B protein homolog isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

BC006404, DC396265

Consensus CDS

CCDS8215.1

UniProtKB/Swiss-Prot

Q9H078

Related

ENSP00000294053, OTTHUMP00000237215, ENST00000294053, OTTHUMT00000396889

Conserved Domains (5) summary

cd00204
Location:161 – 315
Blast Score: 159

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd00009
Location:348 – 502
Blast Score: 174

AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...

smart00382
Location:373 – 510
Blast Score: 149

AAA; ATPases associated with a variety of cellular activities

pfam12796
Location:125 – 195
Blast Score: 172

Ank_2; Ankyrin repeats (3 copies)

cl11083
Location:573 – 651
Blast Score: 139

ClpB_D2-small; C-terminal, D2-small domain, of ClpB protein

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000011.9 Reference GRCh37.p5 Primary Assembly

Range

72003469..72145568, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000143.1 Alternate HuRef

Range

68296594..68438650, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AP000593.4 (81283..121496)	None
genomic	AP002892.3	None
genomic	AP003785.3 (10766..77650)	None
genomic	CH471076.1	EAW74858.1
		EAW74859.1
		EAW74860.1
mRNA	AK023214.1	BAB14467.1
mRNA	AK302006.1	BAG63409.1
mRNA	AK302069.1	BAG63459.1
mRNA	AK302158.1	BAG63526.1
mRNA	AL136909.1	CAB66843.1
mRNA	AL834484.1	CAD39142.1
mRNA	BC006257.2	AAH06257.1
mRNA	BC006404.2	AAH06404.1
other-genetic	EU176435.1	ABW03886.1
other-genetic	EU176772.1	ABW03573.1