SGPP1 sphingosine-1-phosphate phosphatase 1 [Homo sapiens] - Gene

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Summary

Official Symbol: SGPP1provided by HGNC
Official Full Name: sphingosine-1-phosphate phosphatase 1provided by HGNC
Primary source: HGNC:17720
See related: Ensembl:ENSG00000126821; HPRD:10226; MIM:612826; Vega:OTTHUMG00000029080
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SPPase1
Summary: Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid metabolite that regulates diverse biologic processes. SGPP1 catalyzes the degradation of S1P via salvage and recycling of sphingosine into long-chain ceramides (Mandala et al., 2000 [PubMed 10859351]; Le Stunff et al., 2007 [PubMed 17895250]).[supplied by OMIM, Jun 2009]

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Genomic context

Location :: 14q23.2

Sequence :: Chromosome: 14; NC_000014.8 (64150934..64194756, complement)

See SGPP1 in Epigenomics, MapViewer

Chromosome 14 - NC_000014.8 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

S1P is elevated in patients with IPF, correlates with the lung function and mediates EMT.
Title: Sphingosine-1-phosphate is increased in patients with idiopathic pulmonary fibrosis and mediates epithelial to mesenchymal transition.
doxorubicin switches protective autophagy in SPP1-depleted cells to apoptosis by calpain-mediated Atg5 cleavage.
Title: Autophagy induced by deficiency of sphingosine-1-phosphate phosphohydrolase 1 is switched to apoptosis by calpain-mediated autophagy-related gene 5 (Atg5) cleavage.
Under normal circumstances, the retinal vascular pericytes maintain pericyte-endothelial contacts and vascular barrier function through the secretion of sphingosine 1-phosphate.
Title: Pericyte-derived sphingosine 1-phosphate induces the expression of adhesion proteins and modulates the retinal endothelial cell barrier.
SPP1 by regulating intracellular S1P homeostasis, can control the UPR and ER stress-induced autophagy.
Title: Sphingosine-1-phosphate phosphohydrolase-1 regulates ER stress-induced autophagy.
Sphingosine kinase 2, but not sphingosine kinase 1, acted in concert with SPP-1 to regulate recycling of sphingosine into ceramide.
Title: Recycling of sphingosine is regulated by the concerted actions of sphingosine-1-phosphate phosphohydrolase 1 and sphingosine kinase 2.
SPP-1 regulates ceramide levels in the ER and thus influences the anterograde membrane transport of both ceramide and proteins from the ER to the Golgi apparatus.
Title: Sphingosine-1-phosphate phosphohydrolase regulates endoplasmic reticulum-to-golgi trafficking of ceramide.
sphingosine-1-phosphate phosphatase 1 plays roles in the regulation of intra- and extracellular sphingosine-1-phosphate levels and cell viability
Title: Role of human sphingosine-1-phosphate phosphatase 1 in the regulation of intra- and extracellular sphingosine-1-phosphate levels and cell viability.
sphingosine-1-phosphate phosphatase 1 has a role in epidermal growth factor-induced chemotaxis
Title: Role of sphingosine-1-phosphate phosphatase 1 in epidermal growth factor-induced chemotaxis.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

Genetic determinants of circulating sphingolipid concentrations in European populations.

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_110418.1			BIND	PubMed	SGPP1 (hSPPase1) dephosphorylates S1P.
NP_110418.1			BIND	PubMed	SGPP1 (hSPPase1) dephosphorylates dihydro-S1P.
BioGRID:123508	BioGRID:119793	S1PR5	BioGRID	PubMed	Reconstituted Complex

Function	Evidence Code	Pubs
hydrolase activity	IEA Inferred from Electronic Annotation more info
sphingosine-1-phosphate phosphatase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
apoptotic process	IEA Inferred from Electronic Annotation more info
dephosphorylation	IEA Inferred from Electronic Annotation more info
small molecule metabolic process	TAS Traceable Author Statement more info
sphinganine-1-phosphate metabolic process	IEA Inferred from Electronic Annotation more info
sphingolipid biosynthetic process	TAS Traceable Author Statement more info
sphingolipid metabolic process	TAS Traceable Author Statement more info
sphingosine metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
endoplasmic reticulum membrane	TAS Traceable Author Statement more info
integral to membrane	IEA Inferred from Electronic Annotation more info
membrane	IEA Inferred from Electronic Annotation more info
membrane fraction	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: sphingosine-1-phosphate phosphatase 1

Names: sphingosine-1-phosphate phosphatase 1; spp1; hSPP1; hSPPase1; sphingosine-1-phosphatase 1

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_030791.2 → NP_110418.1 sphingosine-1-phosphate phosphatase 1

Status: PROVISIONAL

Source sequence(s)

BC063839

Consensus CDS

CCDS9760.1

UniProtKB/Swiss-Prot

Q9BX95

Related

ENSP00000247225, OTTHUMP00000028107, ENST00000247225, OTTHUMT00000072626

Conserved Domains (2) summary

cd03388
Location:126 – 275
Blast Score: 542

PAP2_SPPase1; PAP2_like proteins, sphingosine-1-phosphatase subfamily. Sphingosine-1-phosphatase is an intracellular enzyme located in the endoplasmic reticulum, which regulates the level of sphingosine-1-phosphate (S1P), a bioactive lipid. S1P acts as a second ...

PLN02525
Location:143 – 435
Blast Score: 248

PLN02525; phosphatidic acid phosphatase family protein

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000014.8 Reference GRCh37.p5 Primary Assembly

Range

64150934..64194756, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000146.1 Alternate HuRef

Range

44317325..44361142, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AL161670.4 (85002..128824)	None
genomic	CH471061.1	EAW80834.1
mRNA	AF349315.1	AAK26660.1
mRNA	AJ293294.1	CAC17772.1
mRNA	AK314188.1	BAG36867.1
mRNA	BC063839.1	AAH63839.1
mRNA	BC070060.1	AAH70060.1