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Smad7 SMAD family member 7 [ Rattus norvegicus (Norway rat) ]

Gene ID: 81516, updated on 8-May-2016
Official Symbol
Smad7provided by RGD
Official Full Name
SMAD family member 7provided by RGD
Primary source
RGD:69314
See related
Ensembl:ENSRNOG00000018359
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as
Madh7
Summary
negative regulator of TGF-beta and activin [RGD, Feb 2006]
Orthologs
Location:
18q12.3
Exon count:
4
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (71395830..71424164)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 18 NC_005117.3 (70530559..70558932)

Chromosome 18 - NC_005117.4Genomic Context describing neighboring genes Neighboring gene dymeclin Neighboring gene uncharacterized LOC102556053 Neighboring gene CBP80/20-dependent translation initiation factor Neighboring gene peroxisomal biogenesis factor 19-like Neighboring gene peroxisomal biogenesis factor 19-like

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
I-SMAD binding IEA
Inferred from Electronic Annotation
more info
 
I-SMAD binding ISO
Inferred from Sequence Orthology
more info
 
activin binding IEA
Inferred from Electronic Annotation
more info
 
activin binding ISO
Inferred from Sequence Orthology
more info
 
beta-catenin binding IEA
Inferred from Electronic Annotation
more info
 
beta-catenin binding ISO
Inferred from Sequence Orthology
more info
 
collagen binding IEA
Inferred from Electronic Annotation
more info
 
collagen binding ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription factor activity, sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
transcription regulatory region DNA binding IEA
Inferred from Electronic Annotation
more info
 
transcription regulatory region DNA binding ISO
Inferred from Sequence Orthology
more info
 
transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity IEA
Inferred from Electronic Annotation
more info
 
transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity ISO
Inferred from Sequence Orthology
more info
 
type I transforming growth factor beta receptor binding IEA
Inferred from Electronic Annotation
more info
 
type I transforming growth factor beta receptor binding ISO
Inferred from Sequence Orthology
more info
 
ubiquitin protein ligase binding IEA
Inferred from Electronic Annotation
more info
 
ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
adherens junction assembly IEA
Inferred from Electronic Annotation
more info
 
adherens junction assembly ISO
Inferred from Sequence Orthology
more info
 
artery morphogenesis IEA
Inferred from Electronic Annotation
more info
 
artery morphogenesis ISO
Inferred from Sequence Orthology
more info
 
cellular protein complex localization IEA
Inferred from Electronic Annotation
more info
 
cellular protein complex localization ISO
Inferred from Sequence Orthology
more info
 
cellular response to transforming growth factor beta stimulus ISO
Inferred from Sequence Orthology
more info
 
intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
negative regulation of BMP signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of pathway-restricted SMAD protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of pathway-restricted SMAD protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of peptidyl-serine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of peptidyl-threonine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of peptidyl-threonine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
negative regulation of sequence-specific DNA binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of sequence-specific DNA binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription by competitive promoter binding IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription by competitive promoter binding ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription from RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription, DNA-templated IEP
Inferred from Expression Pattern
more info
PubMed 
negative regulation of transforming growth factor beta receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of ubiquitin-protein transferase activity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
 
pathway-restricted SMAD protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
pathway-restricted SMAD protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
protein stabilization IEA
Inferred from Electronic Annotation
more info
 
protein stabilization ISO
Inferred from Sequence Orthology
more info
 
regulation of activin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
regulation of activin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
regulation of cardiac muscle contraction IEA
Inferred from Electronic Annotation
more info
 
regulation of cardiac muscle contraction ISO
Inferred from Sequence Orthology
more info
 
regulation of epithelial to mesenchymal transition IEA
Inferred from Electronic Annotation
more info
 
regulation of epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
 
regulation of transforming growth factor beta receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
response to laminar fluid shear stress IEA
Inferred from Electronic Annotation
more info
 
response to laminar fluid shear stress ISO
Inferred from Sequence Orthology
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
transforming growth factor beta receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
ureteric bud development IEA
Inferred from Electronic Annotation
more info
 
ventricular cardiac muscle tissue morphogenesis IEA
Inferred from Electronic Annotation
more info
 
ventricular cardiac muscle tissue morphogenesis ISO
Inferred from Sequence Orthology
more info
 
ventricular septum morphogenesis IEA
Inferred from Electronic Annotation
more info
 
ventricular septum morphogenesis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
catenin complex IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with catenin complex ISO
Inferred from Sequence Orthology
more info
 
cell-cell adherens junction IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with cell-cell adherens junction ISO
Inferred from Sequence Orthology
more info
 
centrosome IEA
Inferred from Electronic Annotation
more info
 
centrosome ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleolus IEA
Inferred from Electronic Annotation
more info
 
nucleolus ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
protein complex ISO
Inferred from Sequence Orthology
more info
 
transcription factor complex IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
mothers against decapentaplegic homolog 7
Names
MAD (mothers against decapentaplegic, Drosophila) homolog 7
MAD homolog 7
SMAD 7
mothers against DPP homolog 7

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030858.1NP_110485.1  mothers against decapentaplegic homolog 7

    See identical proteins and their annotated locations for NP_110485.1

    Status: PROVISIONAL

    Source sequence(s)
    AF159626
    UniProtKB/Swiss-Prot
    O88406
    UniProtKB/TrEMBL
    A0A0G2JSQ5
    Related
    ENSRNOP00000024831, ENSRNOT00000024831
    Conserved Domains (2) summary
    cd10494
    Location:60205
    MH1_SMAD_7; N-terminal Mad Homology 1 (MH1) domain in SMAD7
    cd10500
    Location:254424
    MH2_SMAD_7; C-terminal Mad Homology 2 (MH2) domain in SMAD7

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005117.4 Reference Rnor_6.0 Primary Assembly

    Range
    71395830..71424164
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006254959.2XP_006255021.1  

    Conserved Domains (2) summary
    cd10494
    Location:60205
    MH1_SMAD_7; N-terminal Mad Homology 1 (MH1) domain in SMAD7
    cd10500
    Location:253423
    MH2_SMAD_7; C-terminal Mad Homology 2 (MH2) domain in SMAD7

Alternate Rn_Celera

Genomic

  1. AC_000086.1 Alternate Rn_Celera

    Range
    67155575..67183461
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)