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    CAMK2A calcium/calmodulin-dependent protein kinase II alpha [ Homo sapiens ]

    Gene ID: 815, updated on 19-May-2012
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    Summary

    Official Symbol
    CAMK2Aprovided by HGNC
    Official Full Name
    calcium/calmodulin-dependent protein kinase II alphaprovided by HGNC
    Primary source
    HGNC:1460
    See related
    Ensembl:ENSG00000070808; HPRD:06532; MIM:114078; Vega:OTTHUMG00000134281
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CAMKA; KIAA0968
    Summary
    The product of this gene belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Nov 2008]
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    Genomic context

    Location :
    5q32
    Sequence :
    Chromosome: 5; NC_000005.9 (149599054..149669403, complement)
    See CAMK2A in Epigenomics, MapViewer

    Chromosome 5 - NC_000005.9Genomic Context describing neighboring genes Neighboring gene caudal type homeobox 1 Neighboring gene solute carrier family 6 (neurotransmitter transporter, L-proline), member 7 Neighboring gene arylsulfatase family, member I Neighboring gene Treacher Collins-Franceschetti syndrome 1

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration. Martins-de-Souza D, et al. J Proteome Res, 2012 Apr 6. PMID 22360420.
    2. Large T-antigen up-regulates Kv4.3 K⁺ channels through Sp1, and Kv4.3 K⁺ channels contribute to cell apoptosis and necrosis through activation of calcium/calmodulin-dependent protein kinase II. Li Q, et al. Biochem J, 2012 Feb 1. PMID 22023388.
    3. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    4. Association of ADAM10 and CAMK2A polymorphisms with conduct disorder: evidence from family-based studies. Jian XQ, et al. J Abnorm Child Psychol, 2011 Aug. PMID 21611732.
    5. Characterization of a central Ca2+/calmodulin-dependent protein kinase IIalpha/beta binding domain in densin that selectively modulates glutamate receptor subunit phosphorylation. Jiao Y, et al. J Biol Chem, 2011 Jul 15. PMID 21610080.

    See all (122) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. A protein encoded by this locus was found to be differentially expressed in postmortem brains from patients with atypical frontotemporal lobar degeneration.
      Title: Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration.
    2. Kv4.3 K channels contribute to cell apoptosis and necrosis through activating CaMKII.
      Title: Large T-antigen up-regulates Kv4.3 K⁺ channels through Sp1, and Kv4.3 K⁺ channels contribute to cell apoptosis and necrosis through activation of calcium/calmodulin-dependent protein kinase II.
    3. Characterization of a central Ca2+/calmodulin-dependent protein kinase IIalpha/beta binding domain in densin that selectively modulates glutamate receptor subunit phosphorylation.
      Title: Characterization of a central Ca2+/calmodulin-dependent protein kinase IIalpha/beta binding domain in densin that selectively modulates glutamate receptor subunit phosphorylation.
    4. 20 single nucleotide polymorphisms had suggestive associations with conduct disorder, nine of which were located in known genes, including CAMK2A
      Title: Association of ADAM10 and CAMK2A polymorphisms with conduct disorder: evidence from family-based studies.
    5. Mice heterozygous for a null mutation of the alpha-isoform of calcium/calmodulin-dependent protein kinase II (alpha-CaMKII+/-) have profoundly dysregulated behaviours and impaired neuronal development in the dentate gyrus
      Title: Alpha-CaMKII deficiency causes immature dentate gyrus, a novel candidate endophenotype of psychiatric disorders.
    6. Data show that he calmodulin-CKII peptide system allows the study of photounbinding under different dissociation constants without changing the molecular system.
      Title: Photounbinding of calmodulin from a family of CaM binding peptides.
    7. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    8. Knockdown of spinal CaMKIIalpha attentuates opioid-induced hyperalgesia.
      Title: Ca2+/calmodulin-dependent protein kinase II alpha is required for the initiation and maintenance of opioid-induced hyperalgesia.
    9. Data show that data provide a novel mechanism whereby CaMKII may regulate the proteasome in neurons to facilitate remodeling of synaptic connections through protein degradation.
      Title: Regulation of the proteasome by neuronal activity and calcium/calmodulin-dependent protein kinase II.
    10. Phosphorylation or a phosphorylation mimicking mutation on NR2B (NR2B-S1303D) abolishes the Ca(2+)/calmodulin-independent binding whereas it allows the Ca(2+)/calmodulin-dependent binding of alpha-CaMKII in vitro.
      Title: Phosphorylation status of the NR2B subunit of NMDA receptor regulates its interaction with calcium/calmodulin-dependent protein kinase II.
    Submit: New GeneRIF Correction See all (32)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat inhibits the activation of CAMKII elicited via LFA-1 in NK cells, providing evidence that Tat inhibits NK cell activation which might contribute to the impairment of natural immunity in HIV-1 infection PubMed
    tat HIV-1 Tat inhibits the activation of CAMKII elicited via beta (3) integrin PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_741960.1 NP_004915.2 ACTN4    BIND  PubMed CAMK2A (CaMKII-alpha) interacts with ACTN4 (alpha-Actinin 4). 
    NP_741960.1 NP_065845.1 LRRC7    BIND  PubMed LRRC7 (Densin-180) interacts with CAMK2A (CaMKII-alpha). This interaction was modeled on a demonstrated interaction between rat LRCC7 and human CAMK2A. 
    Q9UQM7 P12814 ACTN1    HPRD  PubMed  
    Q9UQM7 P35609 ACTN2    HPRD  PubMed  
    Q9UQM7 O43707 ACTN4    HPRD  PubMed  
    Q9UQM7 P16615 ATP2A2    HPRD  PubMed  
    Q9UQM7 Q9UQM7 CAMK2A    HPRD  PubMed  
    Q9UQM7 CaMKII inhibitory protein CAMK2N2    HPRD  PubMed  
    Q9UQM7 Q15078 CDK5R1    HPRD  PubMed  
    Q9UQM7 Q13319 CDK5R2    HPRD  PubMed  
    Q9UQM7 P17676 CEBPB    HPRD  PubMed  
    Q9UQM7 P28329 CHAT    HPRD  PubMed  
    Q9UQM7 Q9UIK4 DAPK2    HPRD  PubMed  
    Q9UQM7 Q12959 DLG1    HPRD  PubMed  
    Q9UQM7 P00533 EGFR    HPRD  PubMed  
    Q9UQM7 P14921 ETS1    HPRD  PubMed  
    Q9UQM7 P14136 GFAP    HPRD  PubMed  
    Q9UQM7 Q05586 GRIN1    HPRD  PubMed  
    Q9UQM7 Q12879 GRIN2A    HPRD  PubMed  
    Q9UQM7 Q13224 GRIN2B    HPRD  PubMed  
    Q9UQM7 Q00613 HSF1    HPRD  PubMed  
    Q9UQM7 O14713 ITGB1BP1    HPRD  PubMed  
    Q9UQM7 P23677 ITPKA    HPRD  PubMed  
    Q9UQM7 P05783 KRT18    HPRD  PubMed  
    Q9UQM7 Q96NW7 LRRC7    HPRD  PubMed  
    Q9UQM7 P10636 MAPT    HPRD  PubMed  
    Q9UQM7 O75970 MPDZ    HPRD  PubMed  
    Q9UQM7 P29475 NOS1    HPRD  PubMed  
    Q9UQM7 P20941 PDC    HPRD  PubMed  
    Q9UQM7 P49593 PPM1F    HPRD  PubMed  
    Q9UQM7 Q15796 SMAD2    HPRD  PubMed  
    Q9UQM7 P11831 SRF    HPRD  PubMed  
    Q9UQM7 Q96PV0 SYNGAP1    HPRD  PubMed  
    Q9UQM7 TANC TANC1    HPRD  PubMed  
    BioGRID:107265 BioGRID:106596 ACTN4    BioGRID  PubMed Two-hybrid 
    BioGRID:107265 BioGRID:106956 ATF1    BioGRID  PubMed Biochemical Activity 
    BioGRID:107265 BioGRID:107259 CALM3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107265 BioGRID:107266 CAMK2B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107265 BioGRID:107267 CAMK2D    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107265 BioGRID:114376 CDK5R1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:107265 BioGRID:119579 CHMP5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107265 BioGRID:107775 CREB1    BioGRID  PubMed Biochemical Activity 
    BioGRID:107265 BioGRID:108083 DLG1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:107265 BioGRID:108085 DLG3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107265 BioGRID:118789 GIT1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107265 BioGRID:109161 GRIN2B    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107265 BioGRID:115331 HDAC5    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107265 BioGRID:250730 Lrrc7    BioGRID  PubMed Affinity Capture-Western; Far Western; Two-hybrid 
    BioGRID:107265 BioGRID:110909 NOS3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107265 BioGRID:111105 PARK2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107265 BioGRID:111351 PLCG1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107265 BioGRID:117406 RCHY1    BioGRID  PubMed Biochemical Activity 
    BioGRID:107265 BioGRID:116646 RIMS1    BioGRID  PubMed Biochemical Activity 
    BioGRID:107265 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107265 BioGRID:113361 YWHAB    BioGRID  PubMed Biochemical Activity 
    BioGRID:107265 BioGRID:116168 YWHAQ    BioGRID  PubMed Affinity Capture-Western 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Activation of NMDA receptor upon glutamate binding and postsynaptic events, organism-specific biosystem (from REACTOME)
      Activation of NMDA receptor upon glutamate binding and postsynaptic events, organism-specific biosystemNMDA receptors are a subtype of ionotropic glutamate receptors that are specifically activated by a glutamate agonist N-methyl-D-aspartate (NMDA). Activation of NMDA receptor involves opening of the ...
    • Amphetamine addiction, organism-specific biosystem (from KEGG)
      Amphetamine addiction, organism-specific biosystemAmphetamine is a psychostimulant drug that exerts persistent addictive effects. Most addictive drugs increase extracellular concentrations of dopamine (DA) in nucleus accumbens (NAc) and medial prefr...
    • Amphetamine addiction, conserved biosystem (from KEGG)
      Amphetamine addiction, conserved biosystemAmphetamine is a psychostimulant drug that exerts persistent addictive effects. Most addictive drugs increase extracellular concentrations of dopamine (DA) in nucleus accumbens (NAc) and medial prefr...
    • CREB phosphorylation through the activation of CaMKII, organism-specific biosystem (from REACTOME)
      CREB phosphorylation through the activation of CaMKII, organism-specific biosystemCa2+ signal generated through NMDA receptor in the post-synaptic neuron activates adenylate cyclase signal transduction, leading to the activation of PKA and phosphorylation and activation of CREB-in...
    • CREB phosphorylation through the activation of Ras, organism-specific biosystem (from REACTOME)
      CREB phosphorylation through the activation of Ras, organism-specific biosystemCa2+ influx through the NMDA receptor initiates subsequent molecular pathways that have a defined role in establishing long-lasting synaptic changes. The molecular signaling initiated by a rise in Ca...
    • Calcium Regulation in the Cardiac Cell, organism-specific biosystem (from WikiPathways)
      Calcium Regulation in the Cardiac Cell, organism-specific biosystemCalcium is a common signaling mechanism, as once it enters the cytoplasm it exerts allosteric regulatory affects on many enzymes and proteins. Calcium can act in signal transduction after influx resu...
    • Calcium signaling pathway, organism-specific biosystem (from KEGG)
      Calcium signaling pathway, organism-specific biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
    • Calcium signaling pathway, conserved biosystem (from KEGG)
      Calcium signaling pathway, conserved biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
    • Cholinergic synapse, organism-specific biosystem (from KEGG)
      Cholinergic synapse, organism-specific biosystemAcetylcholine (ACh) is a neurotransmitter widely distributed in the central (and also peripheral, autonomic and enteric) nervous system (CNS). In the CNS, ACh facilitates many functions, such as lear...
    • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
      Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
    • Dopaminergic synapse, organism-specific biosystem (from KEGG)
      Dopaminergic synapse, organism-specific biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
    • Dopaminergic synapse, conserved biosystem (from KEGG)
      Dopaminergic synapse, conserved biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
    • EGFR1 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      EGFR1 Signaling Pathway, organism-specific biosystemThe androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among ot...
    • ErbB signaling pathway, organism-specific biosystem (from WikiPathways)
      ErbB signaling pathway, organism-specific biosystemThe ErbB protein family or epidermal growth factor receptor (EGFR) family is a family of four structurally related receptor tyrosine kinases. Insufficient ErbB signaling in humans is associated with ...
    • ErbB signaling pathway, organism-specific biosystem (from KEGG)
      ErbB signaling pathway, organism-specific biosystemThe ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including prolife...
    • ErbB signaling pathway, conserved biosystem (from KEGG)
      ErbB signaling pathway, conserved biosystemThe ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including prolife...
    • FGF signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      FGF signaling pathway, organism-specific biosystem
      FGF signaling pathway
    • Gastric acid secretion, organism-specific biosystem (from KEGG)
      Gastric acid secretion, organism-specific biosystemGastric acid is a key factor in normal upper gastrointestinal functions, including protein digestion and calcium and iron absorption, as well as providing some protection against bacterial infections...
    • Gastric acid secretion, conserved biosystem (from KEGG)
      Gastric acid secretion, conserved biosystemGastric acid is a key factor in normal upper gastrointestinal functions, including protein digestion and calcium and iron absorption, as well as providing some protection against bacterial infections...
    • Glioma, organism-specific biosystem (from KEGG)
      Glioma, organism-specific biosystemGliomas are the most common of the primary brain tumors and account for more than 40% of all central nervous system neoplasms. Gliomas include tumours that are composed predominantly of astrocytes (a...
    • Glioma, conserved biosystem (from KEGG)
      Glioma, conserved biosystemGliomas are the most common of the primary brain tumors and account for more than 40% of all central nervous system neoplasms. Gliomas include tumours that are composed predominantly of astrocytes (a...
    • Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity, organism-specific biosystem (from REACTOME)
      Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity, organism-specific biosystemExcitatory synaptic transmission in the brain is carried out by glutamate receptors through the activation of both ionotropic and metabotropic receptors. Ionotropic glutamate receptors are of three ...
    • GnRH signaling pathway, organism-specific biosystem (from KEGG)
      GnRH signaling pathway, organism-specific biosystemGonadotropin-releasing hormone (GnRH) secretion from the hypothalamus acts upon its receptor in the anterior pituitary to regulate the production and release of the gonadotropins, LH and FSH. The GnR...
    • GnRH signaling pathway, conserved biosystem (from KEGG)
      GnRH signaling pathway, conserved biosystemGonadotropin-releasing hormone (GnRH) secretion from the hypothalamus acts upon its receptor in the anterior pituitary to regulate the production and release of the gonadotropins, LH and FSH. The GnR...
    • IFN-gamma pathway, organism-specific biosystem (from Pathway Interaction Database)
      IFN-gamma pathway, organism-specific biosystem
      IFN-gamma pathway
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Interferon Signaling, organism-specific biosystem (from REACTOME)
      Interferon Signaling, organism-specific biosystemInterferons (IFNs) are cytokines that play a central role in initiating immune responses, especially antiviral and antitumor effects. There are three types of IFNs:Type I (IFN-alpha, -beta and others...
    • Interferon gamma signaling, organism-specific biosystem (from REACTOME)
      Interferon gamma signaling, organism-specific biosystemInterferon-gamma (IFN-gamma) belongs to the type II interferon family and is secreted by activated immune cells-primarily T and NK cells, but also B-cells and APC. INFG exerts its effect on cells by ...
    • Long-term potentiation, organism-specific biosystem (from KEGG)
      Long-term potentiation, organism-specific biosystemHippocampal long-term potentiation (LTP), a long-lasting increase in synaptic efficacy, is the molecular basis for learning and memory. Tetanic stimulation of afferents in the CA1 region of the hippo...
    • Long-term potentiation, conserved biosystem (from KEGG)
      Long-term potentiation, conserved biosystemHippocampal long-term potentiation (LTP), a long-lasting increase in synaptic efficacy, is the molecular basis for learning and memory. Tetanic stimulation of afferents in the CA1 region of the hippo...
    • Melanogenesis, organism-specific biosystem (from KEGG)
      Melanogenesis, organism-specific biosystemCutaneous melanin pigment plays a critical role in camouflage, mimicry, social communication, and protection against harmful effects of solar radiation. Melanogenesis is under complex regulatory cont...
    • Melanogenesis, conserved biosystem (from KEGG)
      Melanogenesis, conserved biosystemCutaneous melanin pigment plays a critical role in camouflage, mimicry, social communication, and protection against harmful effects of solar radiation. Melanogenesis is under complex regulatory cont...
    • Myometrial Relaxation and Contraction Pathways, organism-specific biosystem (from WikiPathways)
      Myometrial Relaxation and Contraction Pathways, organism-specific biosystemThis pathway illustrates signaling networks implicated in uterine muscle contraction at labor and quiescence throughout gestation (pregnancy). The muscle of the uterus, responsible for contractile ac...
    • Neuronal System, organism-specific biosystem (from REACTOME)
      Neuronal System, organism-specific biosystemThe human brain contains at least 100 billion neurons, each with the ability to influence many other cells. Clearly, highly sophisticated and efficient mechanisms are needed to enable communication a...
    • Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell, organism-specific biosystem (from REACTOME)
      Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell, organism-specific biosystemThe neurotransmitter in the synaptic cleft released by the pre-synaptic neuron binds specific receptors located on the post-synaptic terminal. These receptors are either ion channels or G protein cou...
    • Neurotrophin signaling pathway, organism-specific biosystem (from KEGG)
      Neurotrophin signaling pathway, organism-specific biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
    • Neurotrophin signaling pathway, conserved biosystem (from KEGG)
      Neurotrophin signaling pathway, conserved biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
    • Noncanonical Wnt signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      Noncanonical Wnt signaling pathway, organism-specific biosystem
      Noncanonical Wnt signaling pathway
    • Olfactory transduction, organism-specific biosystem (from KEGG)
      Olfactory transduction, organism-specific biosystemWithin the compact cilia of the olfactory receptor neurons (ORNs) a cascade of enzymatic activity transduces the binding of an odorant molecule to a receptor into an electrical signal that can be tra...
    • Olfactory transduction, conserved biosystem (from KEGG)
      Olfactory transduction, conserved biosystemWithin the compact cilia of the olfactory receptor neurons (ORNs) a cascade of enzymatic activity transduces the binding of an odorant molecule to a receptor into an electrical signal that can be tra...
    • Oocyte meiosis, organism-specific biosystem (from KEGG)
      Oocyte meiosis, organism-specific biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, homologous chromosomes recombine and then segrega...
    • Oocyte meiosis, conserved biosystem (from KEGG)
      Oocyte meiosis, conserved biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, homologous chromosomes recombine and then segrega...
    • Post NMDA receptor activation events, organism-specific biosystem (from REACTOME)
      Post NMDA receptor activation events, organism-specific biosystemCa2+ influx through the NMDA receptor initiates subsequent molecular pathways that have a defined role in establishing long-lasting synaptic changes. The molecular signaling initiated by a rise in Ca...
    • Ras activation uopn Ca2+ infux through NMDA receptor, organism-specific biosystem (from REACTOME)
      Ras activation uopn Ca2+ infux through NMDA receptor, organism-specific biosystemCa2+ influx through the NMDA receptor leads to the activation of Ras kinase via the activation of RasGRF.
    • TGF-beta Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      TGF-beta Receptor Signaling Pathway, organism-specific biosystem"The TGF beta receptors TGFBR1 and TGFBR2 belong to a subfamily of membrane-bound serine/threonine kinases which are designated as Type I or II based on their structural and functional properties. Th...
    • TGF-beta receptor signaling, organism-specific biosystem (from Pathway Interaction Database)
      TGF-beta receptor signaling, organism-specific biosystem
      TGF-beta receptor signaling
    • Trafficking of AMPA receptors, organism-specific biosystem (from REACTOME)
      Trafficking of AMPA receptors, organism-specific biosystemRepetitive presynaptic activity causes long lasting changes in the postsynaptic transmission by changing the type and the number of AMPA receptors. These changes are brought about by trafficking mec...
    • Transmission across Chemical Synapses, organism-specific biosystem (from REACTOME)
      Transmission across Chemical Synapses, organism-specific biosystemChemical synapses are specialized junctions that are used for communication between neurons, neurons and muscle or gland cells. The synapse involves a pre-synaptic neuron and a post-synaptic neuron,...
    • Trk receptor signaling mediated by PI3K and PLC-gamma, organism-specific biosystem (from Pathway Interaction Database)
      Trk receptor signaling mediated by PI3K and PLC-gamma, organism-specific biosystem
      Trk receptor signaling mediated by PI3K and PLC-gamma
    • Tuberculosis, organism-specific biosystem (from KEGG)
      Tuberculosis, organism-specific biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
    • Tuberculosis, conserved biosystem (from KEGG)
      Tuberculosis, conserved biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
    • Unblocking of NMDA receptor, glutamate binding and activation, organism-specific biosystem (from REACTOME)
      Unblocking of NMDA receptor, glutamate binding and activation, organism-specific biosystemAt resting membrane potential the NMDA receptor is blocked by extracellular Mg2+ ions and therefore is not activated in this state by ligands (glutamate, glycine, NMDA). The voltage block is removed ...
    • Wnt Signaling Pathway NetPath, organism-specific biosystem (from WikiPathways)
      Wnt Signaling Pathway NetPath, organism-specific biosystemWnt family of proteins are a large family of cysteine-rich secreted glycoproteins that regulate cell-cell interactions. They bind to members of the Frizzled family of 7 transmembrane receptors. Bindi...
    • Wnt signaling pathway, organism-specific biosystem (from KEGG)
      Wnt signaling pathway, organism-specific biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
    • Wnt signaling pathway, conserved biosystem (from KEGG)
      Wnt signaling pathway, conserved biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    calmodulin-dependent protein kinase activity TAS
    Traceable Author Statement
    more info
    		  
    kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    cytokine-mediated signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    interferon-gamma-mediated signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    positive regulation of NF-kappaB transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    synaptic transmission TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    cell junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytosol TAS
    Traceable Author Statement
    more info
    		  
    endocytic vesicle membrane TAS
    Traceable Author Statement
    more info
    		  
    nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    presynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    calcium/calmodulin-dependent protein kinase type II subunit alpha
    Names
    calcium/calmodulin-dependent protein kinase type II subunit alpha
    CaMKIINalpha
    CaMK-II alpha subunit
    caMK-II subunit alpha
    CaM-kinase II alpha chain
    CaM kinase II alpha subunit
    caM kinase II subunit alpha
    calcium/calmodulin-dependent protein kinase II alpha-B subunit
    calcium/calmodulin-dependent protein kinase type II alpha chain
    calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha
    NP_057065.2
    NP_741960.1
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_015981.3 → NP_057065.2  calcium/calmodulin-dependent protein kinase type II subunit alpha isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript, and it encodes the longer protein (isoform 1).
      Source sequence(s)
      AC011372, AK289776, BC040457, BF951952
      Consensus CDS
      CCDS43387.1
      UniProtKB/TrEMBL
      A8K161
      UniProtKB/TrEMBL
      Q8IWE0
      Related
      ENSP00000381412, OTTHUMP00000165788, ENST00000398376, OTTHUMT00000258870
      Conserved Domains (3) summary
      cd05123
      Location:19 – 270
      Blast Score: 602
      STKc_AGC; Catalytic domain of AGC family Protein Serine/Threonine Kinases
      smart00220
      Location:13 – 271
      Blast Score: 833
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl09109
      Location:357 – 484
      Blast Score: 595
      NTF2_like; Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of ...

    2. NM_171825.2 → NP_741960.1  calcium/calmodulin-dependent protein kinase type II subunit alpha isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame segment of the coding region, compared to variant 1. It encodes a shorter protein (isoform 2), that is missing an internal segment when it is compared to isoform 1.
      Source sequence(s)
      AB023185, AC011372, AK289776, BC040457, BF951952
      Consensus CDS
      CCDS43386.1
      UniProtKB/TrEMBL
      A8K161
      UniProtKB/TrEMBL
      Q7LDD5
      UniProtKB/TrEMBL
      Q8IWE0
      UniProtKB/Swiss-Prot
      Q9UQM7
      Related
      ENSP00000261793, OTTHUMP00000165787, ENST00000348628, OTTHUMT00000258869
      Conserved Domains (3) summary
      cd05123
      Location:19 – 270
      Blast Score: 603
      STKc_AGC; Catalytic domain of AGC family Protein Serine/Threonine Kinases
      smart00220
      Location:13 – 271
      Blast Score: 834
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl09109
      Location:346 – 473
      Blast Score: 595
      NTF2_like; Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of ...

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000005.9 Reference GRCh37.p5 Primary Assembly

      Range
      149599054..149669403, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000137.1 Alternate HuRef

      Range
      144747170..144817356, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC011372.7 (1176..4146) None
    genomic CH471062.2 EAW61741.1
      EAW61742.1
    mRNA AB023185.1 BAA76812.1
    mRNA AF091486.1 AAD55815.1
    mRNA AF145710.1 AAD30558.1
    mRNA AF145711.1 AAD30559.1
    mRNA AK289776.1 BAF82465.1
    mRNA AK308853.1 None
    mRNA AY429524.1 None
    mRNA BC040457.1 AAH40457.1
    mRNA BF951952.1 None
    other-genetic EU832105.1 ACE87455.1
    other-genetic EU832199.1 ACE86769.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7LDD5 GenPept UniProtKB/TrEMBL:Q7LDD5
    Q8IWE0 GenPept UniProtKB/TrEMBL:Q8IWE0
    Q9UQM7.2 GenPept UniProtKB/Swiss-Prot:Q9UQM7
    Help top of page

    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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