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    POLR2M polymerase (RNA) II (DNA directed) polypeptide M [ Homo sapiens ]

    Gene ID: 81488, updated on 4-Feb-2012
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    Summary

    Official Symbol
    POLR2Mprovided by HGNC
    Official Full Name
    polymerase (RNA) II (DNA directed) polypeptide Mprovided by HGNC
    Primary source
    HGNC:14862
    See related
    Ensembl:ENSG00000255529; HPRD:07575; MIM:606485; Vega:OTTHUMG00000166486
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GCOM1; Gdown; Gdown1; GRINL1A
    Summary
    This gene encodes a subunit of RNA polymerase II, a protein complex that is responsible for synthesizing messenger RNA in eukaryotes. The encoded protein functions as a component of a specific form of RNA polymerase II termed Pol II(G). This protein may act as a negative regulator of activator-dependent transcription. Alternate splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring upstream gene MYZAP (myocardial zonula adherens protein). [provided by RefSeq, Nov 2011]
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    Genomic context

    Location :
    15q21.3
    Sequence :
    Chromosome: 15; NC_000015.9 (57998901..58009753)
    See POLR2M in Epigenomics, MapViewer

    Chromosome 15 - NC_000015.9Genomic Context describing neighboring genes Neighboring gene cingulin-like 1 Neighboring gene ribosomal protein S13 pseudogene 7 Neighboring gene calponin 2 pseudogene Neighboring gene aldehyde dehydrogenase 1 family, member A2 Neighboring gene aquaporin 9

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Structural basis for the interaction between dynein light chain 1 and the glutamate channel homolog GRINL1A. García-Mayoral MF, et al. FEBS J, 2010 May. PMID 20412299.
    2. A quantitative atlas of mitotic phosphorylation. Dephoure N, et al. Proc Natl Acad Sci U S A, 2008 Aug 5. PMID 18669648.
    3. Alterations in expression of glutamatergic transporters and receptors in sporadic Alzheimer's disease. Jacob CP, et al. J Alzheimers Dis, 2007 Mar. PMID 17361039.
    4. Diversity of translation start sites may define increased complexity of the human short ORFeome. Oyama M, et al. Mol Cell Proteomics, 2007 Jun. PMID 17317662.
    5. A Mediator-responsive form of metazoan RNA polymerase II. Hu X, et al. Proc Natl Acad Sci U S A, 2006 Jun 20. PMID 16769904.

    See all (22) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Data identify GRINL1A as a membrane-associated DYNLL1 binding partner and suggest that additional DYNLL1-binding partners are present near this glutamate channel homolog.
      Title: Structural basis for the interaction between dynein light chain 1 and the glutamate channel homolog GRINL1A.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    GRINL1A downstream protein Gdown1 Q9NZD4 AHSP    HPRD  PubMed  
    GRINL1A downstream protein Gdown1 Q8IWG5 ANKHD1    HPRD  PubMed  
    GRINL1A downstream protein Gdown1 P05090 APOD    HPRD  PubMed  
    GRINL1A downstream protein Gdown1 P53567 CEBPG    HPRD  PubMed  
    GRINL1A downstream protein Gdown1 Q13574 DGKZ    HPRD  PubMed  
    GRINL1A downstream protein Gdown1 Q9P298 HIGD1B    HPRD  PubMed  
    GRINL1A downstream protein Gdown1 Q9P2H0 KIAA1377    HPRD  PubMed  
    GRINL1A downstream protein Gdown1 Q8NEV4 MYO3A    HPRD  PubMed  
    GRINL1A downstream protein Gdown1 Myosin 9A MYO9A    HPRD  PubMed  
    GRINL1A downstream protein Gdown1 P35998 PSMC2    HPRD  PubMed  
    GRINL1A downstream protein Gdown1 Q9BQ04 RBM4B    HPRD  PubMed  
    GRINL1A downstream protein Gdown1 P62424 RPL7A    HPRD  PubMed  
    GRINL1A downstream protein Gdown1 Q96GD3 SCMH1    HPRD  PubMed  
    GRINL1A downstream protein Gdown1 O15304 SIVA1    HPRD  PubMed  
    GRINL1A downstream protein Gdown1 Q9NVV9 THAP1    HPRD  PubMed  
    GRINL1A downstream protein Gdown1 O14949 UQCRQ    HPRD  PubMed  
    GRINL1A downstream protein Gdown1 Q96FK6 WDR89    HPRD  PubMed  
    GRINL1A downstream protein Gdown1 Q86VK4 ZNF410    HPRD  PubMed  
    BioGRID:123498 BioGRID:119476 AHSP    BioGRID  PubMed Two-hybrid 
    BioGRID:123498 BioGRID:120230 ANKHD1    BioGRID  PubMed Two-hybrid 
    BioGRID:123498 BioGRID:106844 APOD    BioGRID  PubMed Two-hybrid 
    BioGRID:123498 BioGRID:107483 CEBPG    BioGRID  PubMed Two-hybrid 
    BioGRID:123498 BioGRID:114095 DGKZ    BioGRID  PubMed Two-hybrid 
    BioGRID:123498 BioGRID:119712 HIGD1B    BioGRID  PubMed Two-hybrid 
    BioGRID:123498 BioGRID:121617 KIAA1377    BioGRID  PubMed Two-hybrid 
    BioGRID:123498 BioGRID:119814 MYO3A    BioGRID  PubMed Two-hybrid 
    BioGRID:123498 BioGRID:110733 MYO9A    BioGRID  PubMed Two-hybrid 
    BioGRID:123498 BioGRID:110811 NEDD4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123498 BioGRID:111674 PSMC2    BioGRID  PubMed Two-hybrid 
    BioGRID:123498 BioGRID:123760 RBM4B    BioGRID  PubMed Two-hybrid 
    BioGRID:123498 BioGRID:112050 RPL7A    BioGRID  PubMed Two-hybrid 
    BioGRID:123498 BioGRID:116609 SCMH1    BioGRID  PubMed Two-hybrid 
    BioGRID:123498 BioGRID:120448 THAP1    BioGRID  PubMed Two-hybrid 
    BioGRID:123498 BioGRID:117991 UQCRQ    BioGRID  PubMed Two-hybrid 
    BioGRID:123498 BioGRID:125208 WDR89    BioGRID  PubMed Two-hybrid 
    BioGRID:123498 BioGRID:121792 ZNF410    BioGRID  PubMed Two-hybrid 
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    General gene information

    Markers

    Genotypes

    Related pseudogene(s)

    1 found   Review record(s) in Gene

    Readthrough GCOM1

    Readthrough gene: GCOM1, Included gene: MYZAP

    Homology

    Clone Names

    • DKFZp586F1918

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA-directed RNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    maintenance of ER location IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
    		  
    nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    protein GRINL1A
    Names
    protein GRINL1A
    protein GRINL1A, isoforms 4/5
    GRINL1A downstream protein Gdown4
    DNA-directed RNA polymerase II subunit M
    DNA-directed RNA polymerase II subunit M, isoforms 4/5
    glutamate receptor, ionotropic, N-methyl D-aspartate-like 1A
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029676.1 RefSeqGene

      Range
      5001..15853
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001018102.1 → NP_001018112.1  protein GRINL1A isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2), also known as Gdown6, uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
      Source sequence(s)
      AK128618, AL050091, AY339380
      Consensus CDS
      CCDS42045.1
      UniProtKB/Swiss-Prot
      P0CAP1
      UniProtKB/Swiss-Prot
      P0CAP2
      UniProtKB/Swiss-Prot
      Q6EEV4
      Related
      ENSP00000369930, OTTHUMP00000163421, ENST00000380557, OTTHUMT00000255811

    2. NM_015532.3 → NP_056347.1  protein GRINL1A isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK074955, AL050091, AY339380
      Consensus CDS
      CCDS32252.1
      UniProtKB/Swiss-Prot
      P0CAP2
      UniProtKB/Swiss-Prot
      Q6EEV4
      Related
      ENSP00000299638, OTTHUMP00000163345, ENST00000299638, OTTHUMT00000255719

    RNA

    1. NR_027390.1 RNA Sequence

      Description
      Transcript Variant: This variant (3), also called Gdown4, uses an alternate splice site in the 5' coding region, compared to variant 1, that results in a frameshift. This variant is represented as non-coding because the use of either the first or most supported translation start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC090651, AL050091, AY341344

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000015.9 Reference GRCh37.p5 Primary Assembly

      Range
      57998901..58009753
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000147.1 Alternate HuRef

      Range
      34821915..34832716
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC090651.3 (88410..99262) None
    genomic CH471082.1 EAW77525.1
      EAW77527.1
    genomic CQ783776.1 CAF86856.1
    mRNA AF086209.1 None
    mRNA AF326773.1 AAK92284.2
    mRNA AK074767.1 BAC11193.1
    mRNA AK074955.1 BAC11313.1
    mRNA AK128618.1 BAC87533.1
    mRNA AK223571.1 BAD97291.1
    mRNA AK308873.1 None
    mRNA AL050091.1 CAB43263.1
    mRNA AY339380.1 AAQ82540.1
    mRNA AY341344.1 AAQ76830.1
    mRNA AY353061.1 AAQ76837.1
    mRNA BC001510.2 AAH01510.1
    mRNA BI833260.1 None
    mRNA BQ072611.1 None
    other-genetic AM392721.1 CAL37599.1
    other-genetic DQ893035.2 ABM83961.1
    other-genetic DQ896276.2 ABM87275.1
    Protein Accession Links
    GenePept Link UniProtKB Link
    P0CAP2.1 GenPept UniProtKB/Swiss-Prot:P0CAP2
    Q53ER8 GenPept UniProtKB/TrEMBL:Q53ER8
    Q6EEV4.1 GenPept UniProtKB/Swiss-Prot:Q6EEV4
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    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
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    Miscellaneous

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