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PF3D7_0514100 ATP-dependent DNA helicase UvrD [ Plasmodium falciparum 3D7 ]

Gene ID: 812956, updated on 16-Oct-2023

Summary

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Gene symbol
PF3D7_0514100
Gene description
ATP-dependent DNA helicase UvrD
Locus tag
PF3D7_0514100
Gene type
protein coding
RNA name
ATP-dependent DNA helicase UvrD
RefSeq status
PROVISIONAL
Organism
Plasmodium falciparum 3D7 (isolate: 3D7)
Lineage
Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
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Genomic context

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Location:
chromosome: 5
Exon count:
1
Sequence:
Chromosome: 5; NC_004326.2 (591338..595663, complement)

Chromosome 5 - NC_004326.2Genomic Context describing neighboring genes Neighboring gene conserved protein, unknown function Neighboring gene tubulin--tyrosine ligase, putative Neighboring gene conserved Plasmodium protein, unknown function Neighboring gene aspartate--tRNA ligase, putative

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_004326.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Plasmodium falciparum UvrD helicase translocates in 3' to 5' direction, colocalizes with MLH and modulates its activity through physical interaction. Ahmad M, et al. PLoS One, 2012. PMID 23185322, Free PMC Article
  2. Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, et al. Nature, 2002 Oct 3. PMID 12368867

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PfUvrD is expressed in the nucleus distinctly in the schizont stages of the intraerythrocytic development of the parasite and it colocalizes with PfMLH.
    Title: Plasmodium falciparum UvrD helicase translocates in 3' to 5' direction, colocalizes with MLH and modulates its activity through physical interaction.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by GeneDB

Function Evidence Code Pubs
enables 3'-5' DNA helicase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables single-stranded DNA helicase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ATP-dependent DNA helicase UvrD
XP_001351699.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004326.2 Reference assembly

    Range
    591338..595663 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001351663.1 → XP_001351699.1  ATP-dependent DNA helicase UvrD [Plasmodium falciparum 3D7]

    See identical proteins and their annotated locations for XP_001351699.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A2I0BU94, Q8I3W6, W4ILJ7
    Conserved Domains (4) summary
    COG0210
    Location:683 → 800
    UvrD; Superfamily I DNA or RNA helicase [Replication, recombination and repair]
    cd18807
    Location:1349 → 1420
    SF1_C_UvrD; C-terminal helicase domain of UvrD family helicases
    cl28899
    Location:437 → 501
    DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily
    cl40735
    Location:38 → 524
    RecB; ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [Replication, recombination and repair]
Nucleotide Protein
Heading Accession and Version

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