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    CALR calreticulin [ Homo sapiens ]

    Gene ID: 811, updated on 19-May-2012
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    Summary

    Official Symbol
    CALRprovided by HGNC
    Official Full Name
    calreticulinprovided by HGNC
    Primary source
    HGNC:1455
    See related
    Ensembl:ENSG00000179218; HPRD:00169; MIM:109091
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RO; CRT; SSA; cC1qR; FLJ26680
    Summary
    Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium. The amino terminus of calreticulin interacts with the DNA-binding domain of the glucocorticoid receptor and prevents the receptor from binding to its specific glucocorticoid response element. Calreticulin can inhibit the binding of androgen receptor to its hormone-responsive DNA element and can inhibit androgen receptor and retinoic acid receptor transcriptional activities in vivo, as well as retinoic acid-induced neuronal differentiation. Thus, calreticulin can act as an important modulator of the regulation of gene transcription by nuclear hormone receptors. Systemic lupus erythematosus is associated with increased autoantibody titers against calreticulin but calreticulin is not a Ro/SS-A antigen. Earlier papers referred to calreticulin as an Ro/SS-A antigen but this was later disproven. Increased autoantibody titer against human calreticulin is found in infants with complete congenital heart block of both the IgG and IgM classes. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    19p13.3-p13.2
    Sequence :
    Chromosome: 19; NC_000019.9 (13049414..13055304)
    See CALR in Epigenomics, MapViewer

    Chromosome 19 - NC_000019.9Genomic Context describing neighboring genes Neighboring gene glutaryl-CoA dehydrogenase Neighboring gene synaptonemal complex central element protein 2 Neighboring gene phenylalanyl-tRNA synthetase, alpha subunit Neighboring gene RAD23 homolog A (S. cerevisiae) Neighboring gene growth arrest and DNA-damage-inducible, gamma interacting protein 1

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Proteomic analysis of the 20S proteasome (PSMA3)-interacting proteins reveals a functional link between the proteasome and mRNA metabolism. Fedorova OA, et al. Biochem Biophys Res Commun, 2011 Dec 16. PMID 22079093.
    2. A physical interaction network of dengue virus and human proteins. Khadka S, et al. Mol Cell Proteomics, 2011 Dec. PMID 21911577.
    3. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    4. A directed protein interaction network for investigating intracellular signal transduction. Vinayagam A, et al. Sci Signal, 2011 Sep 6. PMID 21900206.
    5. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.

    See all (171) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. calreticulin colocalized with viral dsRNA and with the viral NS3 and NS5 proteins in DENV-infected cells
      Title: A physical interaction network of dengue virus and human proteins.
    2. -220A mutation is 1st report of cognition-deficit-associated mutation which reverses human gene promoter to primitive type. speculate basal transcription of CALR gene relating to proximal promoter region has decreased during process human evolution
      Title: Support for down-tuning of the calreticulin gene in the process of human evolution.
    3. study found a unique mutation at nucleotide -220 from transcription start site, located at a conserved genomic block in the CALR gene promote co-occurs with the spectrum of psychoses; this mutation reverts the human promoter sequence to ancestral type
      Title: Reversion of the human calreticulin gene promoter to the ancestral type as a result of a novel psychosis-associated mutation.
    4. a hydrophobic patch was detected on the arm domain that mediates crystal packing and may contribute to calreticulin chaperone function
      Title: Structural and functional relationships between the lectin and arm domains of calreticulin.
    5. Data demonstrate the ability of calreticulin to bind to denatured forms of both IgG and IgY regardless of the glycosylation state of the proteins.
      Title: The interactions of calreticulin with immunoglobulin G and immunoglobulin Y.
    6. These data thus provide a first structural insight into the lectin-independent binding properties of calreticulin and suggest new working hypotheses, including that of a multi-molecular mechanism.
      Title: X-ray structure of the human calreticulin globular domain reveals a peptide-binding area and suggests a multi-molecular mechanism.
    7. calreticulin and thioredoxin were found in patterns of fibroadenoma, mucinous carcinoma, and NST carcinoma, but with different quantitative expression among them.
      Title: Biochemical and ultrastructural correlations of calreticulin and thioredoxin expression in breast mucinous carcinoma and infiltrating ductal carcinoma non-special type.
    8. Increased CD47 expression correlated with high amounts of calreticulin on cancer cells and was necessary for protection from calreticulin-mediated phagocytosis.
      Title: Calreticulin is the dominant pro-phagocytic signal on multiple human cancers and is counterbalanced by CD47.
    9. data suggest that calreticulin expression is associated with more advanced tumors and is a potential prognostic biomarker.
      Title: Clinicopathological significance of calreticulin in breast invasive ductal carcinoma.
    10. Engineered mutations of CRT can directly cause changes in electrostatic energy, van der Waals energy, polar solvation energy, and entropy for interactions of thrombospondin 1 (TSP1) with CRT and, thereby, contribute to loss of TSP1 and CRT binding.
      Title: Molecular and structural insight into the role of key residues of thrombospondin-1 and calreticulin in thrombospondin-1-calreticulin binding.
    Submit: New GeneRIF Correction See all (82)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp160, precursor env The ubiquitous eukaryotic protein calreticulin binds to newly synthesized HIV-1 gp160, suggesting that calreticulin might act as a chaperone PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_004334.1 NP_004334.1 CALR    BIND  PubMed CRT interacts with itself to form a dimer. 
    NP_004334.1 P01892 HLA-A    BIND  PubMed CRT interacts with HLA-A2. This interaction was modeled on a demonstrated interaction between rabbit CRT and human HLA-A2. 
    NP_004334.1 NP_005304.3 PDIA3    BIND  PubMed ERp57 interacts with CRT. This interaction was modeled on a demonstrated interaction between ERp57 from an unspecified source and rabbit CRT. 
    NP_004334.1 NP_000360.1 TSHR    BIND  PubMed TSHR interacts with the molecular chaperone protein calreticulin. This interaction was modeled on a demonstrated interaction between human TSHR and rabbit calreticulin. 
    NP_004334.1 AAL29687.1     BIND  PubMed The measles virus haemagglutinin interacts with the human host chaperone protein calreticulin. 
    P27797 P04114 APOB    HPRD  PubMed  
    P27797 P05067 APP    HPRD  PubMed  
    P27797 P10275 AR    HPRD  PubMed  
    P27797 P61769 B2M    HPRD  PubMed  
    P27797 P27797 CALR    HPRD  PubMed  
    P27797 P15813 CD1D    HPRD  PubMed  
    P27797 P12259 F5    HPRD  PubMed  
    P27797 P00451 F8    HPRD  PubMed  
    P27797 P35555 FBN1    HPRD  PubMed  
    P27797 P02675 FGB    HPRD  PubMed  
    P27797 Q95604 HLA-C    HPRD  PubMed  
    P27797 P08514 ITGA2B    HPRD  PubMed  
    P27797 P26006 ITGA3    HPRD  PubMed  
    P27797 P06756 ITGAV    HPRD  PubMed  
    P27797 P06858 LPL    HPRD  PubMed  
    P27797 Q07954 LRP1    HPRD  PubMed  
    P27797 P11226 MBL2    HPRD  PubMed  
    P27797 P48039 MTNR1A    HPRD  PubMed  
    P27797 P43699 NKX2-1    HPRD  PubMed  
    P27797 P04150 NR3C1    HPRD  PubMed  
    P27797 Q13087 PDIA2    HPRD  PubMed  
    P27797 P30101 PDIA3    HPRD  PubMed  
    P27797 P00750 PLAT    HPRD  PubMed  
    P27797 P60201 PLP1    HPRD  PubMed  
    P27797 P14222 PRF1    HPRD  PubMed  
    P27797 Q14162 SCARF1    HPRD  PubMed  
    P27797 P11166 SLC2A1    HPRD  PubMed  
    P27797 P31645 SLC6A4    HPRD  PubMed  
    P27797 Q6EEV6 SUMO4    HPRD  PubMed  
    P27797 O15533 TAPBP    HPRD  PubMed  
    P27797 P02787 TF    HPRD  PubMed  
    P27797 P07996 THBS1    HPRD  PubMed  
    P27797 P16473 TSHR    HPRD  PubMed  
    P27797 P04275 VWF    HPRD  PubMed  
    BioGRID:107262 BioGRID:223223 AI837181    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107262 BioGRID:106835 APOB    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107262 BioGRID:106848 APP    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107262 BioGRID:106862 AR    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107262 BioGRID:107271 CANX    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107262 BioGRID:107350 CD1D    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107262 BioGRID:107396 CD40    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107262 BioGRID:108314 ELF3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107262 BioGRID:108349 EPB41    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107262 BioGRID:108452 F5    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107262 BioGRID:108535 FGB    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107262 BioGRID:109268 H2AFX    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:107262 BioGRID:109884 ITGA5    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107262 BioGRID:109891 ITGAV    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107262 BioGRID:120905 LRIF1    BioGRID  PubMed Two-hybrid 
    BioGRID:107262 BioGRID:110215 LRP1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107262 BioGRID:111583 MAPK6    BioGRID  PubMed Two-hybrid 
    BioGRID:107262 BioGRID:110323 MBL2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107262 BioGRID:112936 NKX2-1    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:107262 BioGRID:109165 NR3C1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107262 BioGRID:109180 PDIA3    BioGRID  PubMed Affinity Capture-Western; Co-purification; Reconstituted Complex 
    BioGRID:107262 BioGRID:111343 PLAT    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107262 BioGRID:111542 PRF1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107262 BioGRID:111657 PSMA3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107262 BioGRID:112404 SLC2A1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107262 BioGRID:112423 SLC6A4    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107262 BioGRID:112482 SMARCB1    BioGRID  PubMed Two-hybrid 
    BioGRID:107262 BioGRID:112497 SUMO2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107262 BioGRID:132223 SUMO4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107262 BioGRID:112755 TAPBP    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107262 BioGRID:112876 TF    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107262 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107262 BioGRID:113289 VWF    BioGRID  PubMed Affinity Capture-Western 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Activation of Chaperone Genes by ATF6-alpha, organism-specific biosystem (from REACTOME)
      Activation of Chaperone Genes by ATF6-alpha, organism-specific biosystemThe N-terminal fragment of ATF6-alpha contains a bZIP domain and binds the sequence CCACG in ER Stress Response Elements (ERSEs). ATF6-alpha binds ERSEs together with the heterotrimeric transcription...
    • Activation of Chaperones by ATF6-alpha, organism-specific biosystem (from REACTOME)
      Activation of Chaperones by ATF6-alpha, organism-specific biosystemATF6-alpha is a transmembrane protein that normally resides in the Endoplasmic Reticulum (ER) membrane. Here its luminal C-terminal domain is associated with BiP, shielding 2 Golgi-targeting regions ...
    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • Androgen Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Androgen Receptor Signaling Pathway, organism-specific biosystemThe androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among ot...
    • Antigen Presentation: Folding, assembly and peptide loading of class I MHC, organism-specific biosystem (from REACTOME)
      Antigen Presentation: Folding, assembly and peptide loading of class I MHC, organism-specific biosystemUnlike other glycoproteins, correct folding of MHC class I molecules is not sufficient to trigger their exit from the ER, they exit only after peptide loading. Described here is the process of antige...
    • Antigen processing and presentation, organism-specific biosystem (from KEGG)
      Antigen processing and presentation, organism-specific biosystem
      Antigen processing and presentation
    • Antigen processing and presentation, conserved biosystem (from KEGG)
      Antigen processing and presentation, conserved biosystem
      Antigen processing and presentation
    • Antigen processing-Cross presentation, organism-specific biosystem (from REACTOME)
      Antigen processing-Cross presentation, organism-specific biosystemMHC class I molecules generally present peptide antigens derived from proteins synthesized by the cell itself to CD8+ T cells. However, in some circumstances, antigens from extracellular environment ...
    • Asparagine N-linked glycosylation, organism-specific biosystem (from REACTOME)
      Asparagine N-linked glycosylation, organism-specific biosystemN-linked glycosylation is the most important form of post-translational modification for proteins synthesized and folded in the Endoplasmic Reticulum (Stanley P et al, 2009). An early study in 1999 r...
    • Assembly of Viral Components at the Budding Site, organism-specific biosystem (from REACTOME)
      Assembly of Viral Components at the Budding Site, organism-specific biosystemFollowing synthesis on membrane-bound ribosomes, the three viral integral membrane proteins, HA (hemagglutinin), NA (neuraminidase) and M2 (ion channel) enter the host endoplasmic reticulum (ER) wher...
    • Calcium Regulation in the Cardiac Cell, organism-specific biosystem (from WikiPathways)
      Calcium Regulation in the Cardiac Cell, organism-specific biosystemCalcium is a common signaling mechanism, as once it enters the cytoplasm it exerts allosteric regulatory affects on many enzymes and proteins. Calcium can act in signal transduction after influx resu...
    • Calnexin/calreticulin cycle, organism-specific biosystem (from REACTOME)
      Calnexin/calreticulin cycle, organism-specific biosystemThe unfolded protein is recognized by a chaperon protein (calnexin or calreticulin) and the folding process starts. The binding of these protein requires a mono-glucosylated glycan (Caramelo JJ and P...
    • Chagas disease (American trypanosomiasis), organism-specific biosystem (from KEGG)
      Chagas disease (American trypanosomiasis), organism-specific biosystemTrypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they ...
    • Chagas disease (American trypanosomiasis), conserved biosystem (from KEGG)
      Chagas disease (American trypanosomiasis), conserved biosystemTrypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they ...
    • Class I MHC mediated antigen processing & presentation, organism-specific biosystem (from REACTOME)
      Class I MHC mediated antigen processing & presentation, organism-specific biosystemMajor histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular b...
    • Diabetes pathways, organism-specific biosystem (from REACTOME)
      Diabetes pathways, organism-specific biosystemThis module groups several normal processes that have key roles in the synthesis and function of insulin, insulin-like growth factors and ghrelin, and whose derangement is thus central to the pathoge...
    • Disease, organism-specific biosystem (from REACTOME)
      Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
    • ER-Phagosome pathway, organism-specific biosystem (from REACTOME)
      ER-Phagosome pathway, organism-specific biosystemThe other TAP-dependent cross-presentation mechanism in phagocytes is the endoplasmic reticulum (ER)-phagosome model. Desjardins proposed that ER is recruited to the cell surface, where it fuses wit...
    • HTLV-I infection, organism-specific biosystem (from KEGG)
      HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • HTLV-I infection, conserved biosystem (from KEGG)
      HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Influenza Infection, organism-specific biosystem (from REACTOME)
      Influenza Infection, organism-specific biosystemFor centuries influenza epidemics have plagued man, and influenza was probably the disease described by Hippocrates in 412 BC. Today it remains a major cause of morbidity and mortality worldwide with...
    • Influenza Life Cycle, organism-specific biosystem (from REACTOME)
      Influenza Life Cycle, organism-specific biosystemThe virus particle initially associates with a human host cell by binding to sialic acid-containing receptors on the host cell surface. The bound virus is endocytosed by one of four distinct mechanis...
    • Metabolism of proteins, organism-specific biosystem (from REACTOME)
      Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
    • N-glycan trimming in the ER and Calnexin/Calreticulin cycle, organism-specific biosystem (from REACTOME)
      N-glycan trimming in the ER and Calnexin/Calreticulin cycle, organism-specific biosystemAfter being synthesized in the ER membrane the 14-sugars lipid-linked oligosaccharide is co-translationally transferred to an unfolded protein, as described in the previous steps. After this point th...
    • Phagosome, organism-specific biosystem (from KEGG)
      Phagosome, organism-specific biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
    • Phagosome, conserved biosystem (from KEGG)
      Phagosome, conserved biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
    • Post-translational protein modification, organism-specific biosystem (from REACTOME)
      Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
    • Protein processing in endoplasmic reticulum, organism-specific biosystem (from KEGG)
      Protein processing in endoplasmic reticulum, organism-specific biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
    • Protein processing in endoplasmic reticulum, conserved biosystem (from KEGG)
      Protein processing in endoplasmic reticulum, conserved biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
    • Unfolded Protein Response, organism-specific biosystem (from REACTOME)
      Unfolded Protein Response, organism-specific biosystemThe Unfolded Protein Response (UPR) is a regulatory system that protects the Endoplasmic Reticulum (ER) from overload. The UPR is provoked by the accumulation of improperly folded protein in the ER d...
    • Virus Assembly and Release, organism-specific biosystem (from REACTOME)
      Virus Assembly and Release, organism-specific biosystemInfluenza viruses assemble and bud from the apical plasma membrane of polarized cells e.g. lung epithelial cells of the infected host. This asymmetrical process (i.e. apical [Influenza virus] or baso...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    androgen receptor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    calcium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    calcium ion binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    carbohydrate binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    chaperone binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    complement component C1q binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    hormone binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    integrin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    peptide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein binding involved in protein folding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    sugar binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    unfolded protein binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    zinc ion binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    activation of signaling protein activity involved in unfolded protein response TAS
    Traceable Author Statement
    more info
    		  
    antigen processing and presentation of exogenous peptide antigen via MHC class I TAS
    Traceable Author Statement
    more info
    		  
    antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS
    Traceable Author Statement
    more info
    		  
    antigen processing and presentation of peptide antigen via MHC class I TAS
    Traceable Author Statement
    more info
    		  
    cardiac muscle cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    cell cycle arrest IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    cellular calcium ion homeostasis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    cellular protein metabolic process TAS
    Traceable Author Statement
    more info
    		  
    cellular response to lithium ion IEA
    Inferred from Electronic Annotation
    more info
    		  
    cellular response to organic substance IEA
    Inferred from Electronic Annotation
    more info
    		  
    cellular senescence IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    cortical actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    endoplasmic reticulum unfolded protein response TAS
    Traceable Author Statement
    more info
    		  
    glucocorticoid receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    negative regulation of intracellular steroid hormone receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of neuron differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of retinoic acid receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of transcription, DNA-dependent IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of translation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    negative regulation of translation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    peptide antigen assembly with MHC class I protein complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    positive regulation of DNA replication IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    positive regulation of cell cycle IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    positive regulation of cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    positive regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of phagocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    post-translational protein modification TAS
    Traceable Author Statement
    more info
    		  
    protein N-linked glycosylation via asparagine TAS
    Traceable Author Statement
    more info
    		  
    protein export from nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein folding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    protein localization to nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein maturation by protein folding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    protein stabilization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    protein stabilization TAS
    Traceable Author Statement
    more info
    		 PubMed 
    regulation of apoptotic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    regulation of meiosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of transcription, DNA-dependent TAS
    Traceable Author Statement
    more info
    		 PubMed 
    response to drug IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to estradiol stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to testosterone stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    sequestering of calcium ion TAS
    Traceable Author Statement
    more info
    		 PubMed 
    spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    MHC class I peptide loading complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    acrosomal vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    cell surface TAS
    Traceable Author Statement
    more info
    		 PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    endoplasmic reticulum TAS
    Traceable Author Statement
    more info
    		 PubMed 
    endoplasmic reticulum lumen IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    endoplasmic reticulum lumen TAS
    Traceable Author Statement
    more info
    		  
    external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    extracellular space IDA
    Inferred from Direct Assay
    more info
    		  
    integral to lumenal side of endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
    		  
    intracellular TAS
    Traceable Author Statement
    more info
    		 PubMed 
    microsome IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    phagocytic vesicle membrane TAS
    Traceable Author Statement
    more info
    		  
    polysome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    proteinaceous extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    sarcoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    soluble fraction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Help top of page

    General protein information

    Preferred Names
    calreticulin
    Names
    calreticulin
    CRP55
    ERp60
    HACBP
    grp60
    calregulin
    endoplasmic reticulum resident protein 60
    Sicca syndrome antigen A (autoantigen Ro; calreticulin)
    Help top of page

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029662.1 RefSeqGene

      Range
      5001..10891
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_004343.3 → NP_004334.1  calreticulin precursor

      Status: REVIEWED

      Source sequence(s)
      AC092069, BC007911
      Consensus CDS
      CCDS12288.1
      UniProtKB/Swiss-Prot
      P27797
      Related
      ENSP00000320866, ENST00000316448
      Conserved Domains (1) summary
      pfam00262
      Location:22 – 332
      Blast Score: 1102
      Calreticulin; Calreticulin family

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000019.9 Reference GRCh37.p5 Primary Assembly

      Range
      13049414..13055304
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000151.1 Alternate HuRef

      Range
      12621315..12627203
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC092069.2 (45188..51076) None
    genomic AD000092.1 AAB51176.1
    genomic CH471106.1 EAW84330.1
      EAW84331.1
      EAW84332.1
    genomic CS288581.1 CAK18761.1
    genomic JA462404.1 CCD35250.1
    mRNA AB451408.1 BAG70222.1
    mRNA AF087986.1 None
    mRNA AK130190.1 None
    mRNA AK223060.1 BAD96780.1
    mRNA AK295230.1 BAG58223.1
    mRNA AK304492.1 BAG65301.1
    mRNA AY047586.1 AAL13126.1
    mRNA BC002500.2 AAH02500.1
    mRNA BC007911.1 AAH07911.1
    mRNA BC020493.1 AAH20493.1
    mRNA BC107102.2 None
    mRNA BT007448.1 AAP36116.1
    mRNA CR457070.1 CAG33351.1
    mRNA M32294.1 AAA36582.1
    mRNA M84739.1 AAA51916.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P27797.1 GenPept UniProtKB/Swiss-Prot:P27797
    Q53G71 GenPept UniProtKB/TrEMBL:Q53G71
    Help top of page

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

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