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CLPTM1L CLPTM1-like [ Homo sapiens (human) ]

Gene ID: 81037, updated on 8-May-2016
Official Symbol
CLPTM1Lprovided by HGNC
Official Full Name
CLPTM1-likeprovided by HGNC
Primary source
HGNC:HGNC:24308
See related
Ensembl:ENSG00000049656 HPRD:07480; MIM:612585; Vega:OTTHUMG00000131015
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CRR9
Summary
The protein encoded by this gene is a membrane protein whose overexpression in cisplatin-sensitive cells causes apoptosis. Polymorphisms in this gene have been reported to increase susceptibility to several cancers, including lung, pancreatic, and breast cancers. [provided by RefSeq, Nov 2015]
Orthologs
Location:
5p15.33
Exon count:
17
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 5 NC_000005.10 (1317755..1345065, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (1317869..1345180, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374613 Neighboring gene telomerase reverse transcriptase Neighboring gene microRNA 4457 Neighboring gene long intergenic non-protein coding RNA 1511 Neighboring gene solute carrier family 6 member 3

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia.
NHGRI GWA Catalog
A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33.
NHGRI GWA Catalog
A genome-wide association study of lung cancer identifies a region of chromosome 5p15 associated with risk for adenocarcinoma.
NHGRI GWA Catalog
A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci.
NHGRI GWA Catalog
Common 5p15.33 and 6p21.33 variants influence lung cancer risk.
NHGRI GWA Catalog
Deciphering the impact of common genetic variation on lung cancer risk: a genome-wide association study.
NHGRI GWA Catalog
Genetic correction of PSA values using sequence variants associated with PSA levels.
NHGRI GWA Catalog
Genome-wide association study identifies multiple loci associated with bladder cancer risk.
NHGRI GWA Catalog
Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer.
NHGRI GWA Catalog
Genome-wide association study identifies three new melanoma susceptibility loci.
NHGRI GWA Catalog
Germline sequence variants in TGM3 and RGS22 confer risk of basal cell carcinoma.
NHGRI GWA Catalog
Identification of nine new susceptibility loci for testicular cancer, including variants near DAZL and PRDM14.
NHGRI GWA Catalog
Lung cancer susceptibility locus at 5p15.33.
NHGRI GWA Catalog
Sequence variants at the TERT-CLPTM1L locus associate with many cancer types.
NHGRI GWA Catalog
The 5p15.33 locus is associated with risk of lung adenocarcinoma in never-smoking females in Asia.
NHGRI GWA Catalog
Variants near DMRT1, TERT and ATF7IP are associated with testicular germ cell cancer.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ14400, FLJ32533, DKFZp666M1010, DKFZp761M2324

Gene Ontology Provided by GOA

Process Evidence Code Pubs
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
cleft lip and palate transmembrane protein 1-like protein
Names
CLPTM1-like protein
cisplatin resistance related protein CRR9p
cisplatin resistance-related protein 9

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046903.1 RefSeqGene

    Range
    4996..32322
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_030782.4NP_110409.2  cleft lip and palate transmembrane protein 1-like protein

    See identical proteins and their annotated locations for NP_110409.2

    Status: REVIEWED

    Source sequence(s)
    AC114291, BC025305, BQ019182, CD109529
    Consensus CDS
    CCDS3862.1
    UniProtKB/Swiss-Prot
    Q96KA5
    Related
    ENSP00000313854, OTTHUMP00000161634, ENST00000320895, OTTHUMT00000253649
    Conserved Domains (1) summary
    pfam05602
    Location:22421
    CLPTM1; Cleft lip and palate transmembrane protein 1 (CLPTM1)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p2 Primary Assembly

    Range
    1317755..1345065 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011514144.1XP_011512446.1  

    Conserved Domains (1) summary
    pfam05602
    Location:22420
    CLPTM1; Cleft lip and palate transmembrane protein 1 (CLPTM1)

Reference GRCh38.p2 ALT_REF_LOCI_1

Genomic

  1. NT_187547.1 Reference GRCh38.p2 ALT_REF_LOCI_1

    Range
    169122..195710
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018916.2 Alternate CHM1_1.1

    Range
    1317036..1344039 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)