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Trim2 tripartite motif-containing 2 [ Mus musculus (house mouse) ]

Gene ID: 80890, updated on 21-Apr-2024

Summary

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Official Symbol
Trim2provided by MGI
Official Full Name
tripartite motif-containing 2provided by MGI
Primary source
MGI:MGI:1933163
See related
Ensembl:ENSMUSG00000027993 AllianceGenome:MGI:1933163
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
narf; mKIAA0517
Summary
Enables ubiquitin protein ligase activity. Involved in regulation of neuron apoptotic process. Acts upstream of or within cellular response to leukemia inhibitory factor. Predicted to be located in cytoplasm. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 2R. Orthologous to human TRIM2 (tripartite motif containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E18 (RPKM 15.0), cerebellum adult (RPKM 13.7) and 23 other tissues See more
Orthologs
human all
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Genomic context

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Location:
3 F1; 3 37.48 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (84067746..84215659, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (84160439..84308352, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3440 Neighboring gene predicted gene, 30458 Neighboring gene STARR-positive B cell enhancer ABC_E7917 Neighboring gene STARR-positive B cell enhancer ABC_E9214 Neighboring gene meiotic nuclear divisions 1 Neighboring gene STARR-positive B cell enhancer ABC_E1020 Neighboring gene STARR-seq mESC enhancer starr_08077 Neighboring gene STARR-seq mESC enhancer starr_08078 Neighboring gene ribosomal protein L36a pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr3:84032505-84032806 Neighboring gene nuclear encoded tRNA glycine 9 (anticodon GCC) Neighboring gene predicted gene, 40078 Neighboring gene STARR-positive B cell enhancer ABC_E3441 Neighboring gene RIKEN cDNA 4930565D16 gene Neighboring gene STARR-seq mESC enhancer starr_08085 Neighboring gene FH2 domain containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A recessive Trim2 mutation causes an axonal neuropathy in mice. Li JJ, et al. Neurobiol Dis, 2020 Jul. PMID 32205255
  2. Signal-regulatory protein alpha is an anti-viral entry factor targeting viruses using endocytic pathways. Sarute N, et al. PLoS Pathog, 2021 Jun. PMID 34097709, Free PMC Article
  3. TRIM2, a novel member of the antiviral family, limits New World arenavirus entry. Sarute N, et al. PLoS Biol, 2019 Feb. PMID 30726215, Free PMC Article
  4. The E3-ubiquitin ligase TRIM2 regulates neuronal polarization. Khazaei MR, et al. J Neurochem, 2011 Apr. PMID 20796172
  5. A Chromatin Accessibility Atlas of the Developing Human Telencephalon. Markenscoff-Papadimitriou E, et al. Cell, 2020 Aug 6. PMID 32610082, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TRIM2 Selectively Regulates Inflammation-Driven Pathological Angiogenesis without Affecting Physiological Hypoxia-Mediated Angiogenesis.
    Title: TRIM2 Selectively Regulates Inflammation-Driven Pathological Angiogenesis without Affecting Physiological Hypoxia-Mediated Angiogenesis.
  2. TRIM2, a novel member of the antiviral family, limits New World arenavirus entry.
    Title: TRIM2, a novel member of the antiviral family, limits New World arenavirus entry.
  3. a role for TRIM2 in mediating the p42/p44 MAPK-dependent ubiquitination of Bim in rapid ischemic tolerance.
    Title: Identification of a novel Bcl-2-interacting mediator of cell death (Bim) E3 ligase, tripartite motif-containing protein 2 (TRIM2), and its role in rapid ischemic tolerance-induced neuroprotection.
  4. Trim2 has an important function in the regulation of axon outgrowth during development.
    Title: The E3-ubiquitin ligase TRIM2 regulates neuronal polarization.
  5. TRIM2 is an ubiquitin ligase and point to a mechanism regulating neurofilament light subunit metabolism through an ubiquitination pathway that, if deregulated, triggers neurodegeneration
    Title: Deficiency in ubiquitin ligase TRIM2 causes accumulation of neurofilament light chain and neurodegeneration.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0517

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables myosin binding NAS
Non-traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables translation repressor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in negative regulation of translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
tripartite motif-containing protein 2
Names
E3 ubiquitin-protein ligase TRIM2
RING-type E3 ubiquitin transferase TRIM2
neural activity-related ring finger protein
tripartite motif protein 2
tripartite motif protein TRIM2
NP_001258654.1
NP_001258655.1
NP_001258656.1
NP_001258657.1
NP_109631.2
XP_011238598.1
XP_011238599.1
XP_011238600.1
XP_011238601.1
XP_011238602.1
XP_011238603.1
XP_011238604.1
XP_011238605.1
XP_011238606.1
XP_011238607.1
XP_017175302.1
XP_017175303.1
XP_017175304.1
XP_030108777.1
XP_030108778.1
XP_030108779.1
XP_036019315.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271725.1 → NP_001258654.1  tripartite motif-containing protein 2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AK147275, CA751006, CJ100776
    Consensus CDS
    CCDS71257.1
    UniProtKB/TrEMBL
    E9QKC6, Q3URK9
    Related
    ENSMUSP00000049902.5, ENSMUST00000054990.11
    Conserved Domains (7) summary
    smart00502
    Location:187 → 313
    BBC; B-Box C-terminal domain
    smart00336
    Location:139 → 180
    BBOX; B-Box-type zinc finger
    smart00557
    Location:351 → 447
    IG_FLMN; Filamin-type immunoglobulin domains
    COG3391
    Location:516 → 761
    YncE; DNA-binding beta-propeller fold protein YncE [General function prediction only]
    cd00162
    Location:49 → 92
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd14960
    Location:497 → 770
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    pfam00630
    Location:351 → 444
    Filamin; Filamin/ABP280 repeat

  2. NM_001271726.1 → NP_001258655.1  tripartite motif-containing protein 2 isoform 2

    See identical proteins and their annotated locations for NP_001258655.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1. Variants 2, 3, and 5 encode the same isoform (2).
    Source sequence(s)
    AC102235, AK147275, CA751006, CD802800
    Consensus CDS
    CCDS71256.1
    UniProtKB/Swiss-Prot
    Q3UHP5, Q5DU27, Q8C981, Q9ESN6
    UniProtKB/TrEMBL
    Q3TPI3
    Related
    ENSMUSP00000103320.2, ENSMUST00000107692.8
    Conserved Domains (5) summary
    smart00502
    Location:161 → 287
    BBC; B-Box C-terminal domain
    smart00557
    Location:325 → 421
    IG_FLMN; Filamin-type immunoglobulin domains
    cd14960
    Location:471 → 744
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    cd16767
    Location:20 → 65
    RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
    cd19824
    Location:115 → 156
    Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins

  3. NM_001271727.1 → NP_001258656.1  tripartite motif-containing protein 2 isoform 2

    See identical proteins and their annotated locations for NP_001258656.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1. Variants 2, 3, and 5 encode the same isoform (2).
    Source sequence(s)
    AK147275, CA751006, CJ105472
    Consensus CDS
    CCDS71256.1
    UniProtKB/Swiss-Prot
    Q3UHP5, Q5DU27, Q8C981, Q9ESN6
    UniProtKB/TrEMBL
    Q3TPI3
    Related
    ENSMUSP00000103319.2, ENSMUST00000107691.8
    Conserved Domains (5) summary
    smart00502
    Location:161 → 287
    BBC; B-Box C-terminal domain
    smart00557
    Location:325 → 421
    IG_FLMN; Filamin-type immunoglobulin domains
    cd14960
    Location:471 → 744
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    cd16767
    Location:20 → 65
    RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
    cd19824
    Location:115 → 156
    Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins

  4. NM_001271728.1 → NP_001258657.1  tripartite motif-containing protein 2 isoform 2

    See identical proteins and their annotated locations for NP_001258657.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1. Variants 2, 3, and 5 encode the same isoform (2).
    Source sequence(s)
    AK147275, BC058961, CA751006
    Consensus CDS
    CCDS71256.1
    UniProtKB/Swiss-Prot
    Q3UHP5, Q5DU27, Q8C981, Q9ESN6
    UniProtKB/TrEMBL
    Q3TPI3
    Related
    ENSMUSP00000069922.7, ENSMUST00000065380.13
    Conserved Domains (5) summary
    smart00502
    Location:161 → 287
    BBC; B-Box C-terminal domain
    smart00557
    Location:325 → 421
    IG_FLMN; Filamin-type immunoglobulin domains
    cd14960
    Location:471 → 744
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    cd16767
    Location:20 → 65
    RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
    cd19824
    Location:115 → 156
    Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins

  5. NM_030706.3 → NP_109631.2  tripartite motif-containing protein 2 isoform 3

    See identical proteins and their annotated locations for NP_109631.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains a distinct 5' UTR and differs in the 5' coding region, compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK147275, CA751006, CD803806
    Consensus CDS
    CCDS17437.2
    UniProtKB/TrEMBL
    Q3UHH4, Q3URK9
    Related
    ENSMUSP00000103323.3, ENSMUST00000107695.9
    Conserved Domains (5) summary
    smart00502
    Location:178 → 304
    BBC; B-Box C-terminal domain
    smart00557
    Location:342 → 438
    IG_FLMN; Filamin-type immunoglobulin domains
    cd14960
    Location:488 → 761
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    cd16767
    Location:37 → 82
    RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
    cd19824
    Location:132 → 173
    Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    84067746..84215659 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030252918.1 → XP_030108778.1  tripartite motif-containing protein 2 isoform X6

    UniProtKB/TrEMBL
    Q3URK9
    Conserved Domains (5) summary
    smart00502
    Location:179 → 305
    BBC; B-Box C-terminal domain
    smart00557
    Location:343 → 439
    IG_FLMN; Filamin-type immunoglobulin domains
    cd14960
    Location:489 → 762
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    cd16767
    Location:38 → 83
    RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
    cd19824
    Location:133 → 174
    Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins

  2. XM_011240298.3 → XP_011238600.1  tripartite motif-containing protein 2 isoform X4

    UniProtKB/TrEMBL
    Q3URK9
    Conserved Domains (5) summary
    smart00502
    Location:179 → 305
    BBC; B-Box C-terminal domain
    smart00557
    Location:343 → 439
    IG_FLMN; Filamin-type immunoglobulin domains
    cd14960
    Location:489 → 766
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    cd16767
    Location:38 → 83
    RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
    cd19824
    Location:133 → 174
    Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins

  3. XM_017319814.3 → XP_017175303.1  tripartite motif-containing protein 2 isoform X8

    UniProtKB/Swiss-Prot
    Q3UHP5, Q5DU27, Q8C981, Q9ESN6
    UniProtKB/TrEMBL
    Q3TPI3
    Conserved Domains (5) summary
    smart00502
    Location:161 → 287
    BBC; B-Box C-terminal domain
    smart00557
    Location:325 → 421
    IG_FLMN; Filamin-type immunoglobulin domains
    cd14960
    Location:471 → 744
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    cd16767
    Location:20 → 65
    RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
    cd19824
    Location:115 → 156
    Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins

  4. XM_011240301.4 → XP_011238603.1  tripartite motif-containing protein 2 isoform X7

    See identical proteins and their annotated locations for XP_011238603.1

    UniProtKB/TrEMBL
    Q3TPI3
    Conserved Domains (5) summary
    smart00502
    Location:161 → 287
    BBC; B-Box C-terminal domain
    smart00557
    Location:325 → 421
    IG_FLMN; Filamin-type immunoglobulin domains
    cd14960
    Location:471 → 748
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    cd16767
    Location:20 → 65
    RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
    cd19824
    Location:115 → 156
    Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins

  5. XM_017319813.3 → XP_017175302.1  tripartite motif-containing protein 2 isoform X3

    UniProtKB/TrEMBL
    Q3URK9
    Conserved Domains (5) summary
    smart00502
    Location:183 → 309
    BBC; B-Box C-terminal domain
    smart00557
    Location:347 → 443
    IG_FLMN; Filamin-type immunoglobulin domains
    cd14960
    Location:493 → 766
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    cd16767
    Location:42 → 87
    RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
    cd19824
    Location:137 → 178
    Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins

  6. XM_011240302.3 → XP_011238604.1  tripartite motif-containing protein 2 isoform X7

    See identical proteins and their annotated locations for XP_011238604.1

    UniProtKB/TrEMBL
    Q3TPI3
    Conserved Domains (5) summary
    smart00502
    Location:161 → 287
    BBC; B-Box C-terminal domain
    smart00557
    Location:325 → 421
    IG_FLMN; Filamin-type immunoglobulin domains
    cd14960
    Location:471 → 748
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    cd16767
    Location:20 → 65
    RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
    cd19824
    Location:115 → 156
    Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins

  7. XM_030252917.2 → XP_030108777.1  tripartite motif-containing protein 2 isoform X3

    UniProtKB/TrEMBL
    Q3URK9
    Conserved Domains (5) summary
    smart00502
    Location:183 → 309
    BBC; B-Box C-terminal domain
    smart00557
    Location:347 → 443
    IG_FLMN; Filamin-type immunoglobulin domains
    cd14960
    Location:493 → 766
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    cd16767
    Location:42 → 87
    RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
    cd19824
    Location:137 → 178
    Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins

  8. XM_011240297.3 → XP_011238599.1  tripartite motif-containing protein 2 isoform X2

    UniProtKB/TrEMBL
    Q3URK9
    Conserved Domains (5) summary
    smart00502
    Location:183 → 309
    BBC; B-Box C-terminal domain
    smart00557
    Location:347 → 443
    IG_FLMN; Filamin-type immunoglobulin domains
    cd14960
    Location:493 → 770
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    cd16767
    Location:42 → 87
    RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
    cd19824
    Location:137 → 178
    Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins

  9. XM_011240296.2 → XP_011238598.1  tripartite motif-containing protein 2 isoform X1

    UniProtKB/TrEMBL
    Q3URK9
    Conserved Domains (5) summary
    smart00502
    Location:187 → 313
    BBC; B-Box C-terminal domain
    smart00557
    Location:351 → 447
    IG_FLMN; Filamin-type immunoglobulin domains
    cd14960
    Location:497 → 774
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    cd16767
    Location:46 → 91
    RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
    cd19824
    Location:141 → 182
    Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins

  10. XM_011240300.4 → XP_011238602.1  tripartite motif-containing protein 2 isoform X7

    See identical proteins and their annotated locations for XP_011238602.1

    UniProtKB/TrEMBL
    Q3TPI3
    Conserved Domains (5) summary
    smart00502
    Location:161 → 287
    BBC; B-Box C-terminal domain
    smart00557
    Location:325 → 421
    IG_FLMN; Filamin-type immunoglobulin domains
    cd14960
    Location:471 → 748
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    cd16767
    Location:20 → 65
    RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
    cd19824
    Location:115 → 156
    Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins

  11. XM_011240299.4 → XP_011238601.1  tripartite motif-containing protein 2 isoform X5

    UniProtKB/TrEMBL
    Q3URK9
    Conserved Domains (5) summary
    smart00502
    Location:178 → 304
    BBC; B-Box C-terminal domain
    smart00557
    Location:342 → 438
    IG_FLMN; Filamin-type immunoglobulin domains
    cd14960
    Location:488 → 765
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    cd16767
    Location:37 → 82
    RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
    cd19824
    Location:132 → 173
    Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins

  12. XM_017319815.3 → XP_017175304.1  tripartite motif-containing protein 2 isoform X9

    Conserved Domains (2) summary
    smart00557
    Location:49 → 145
    IG_FLMN; Filamin-type immunoglobulin domains
    cd14960
    Location:195 → 468
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins

  13. XM_011240304.4 → XP_011238606.1  tripartite motif-containing protein 2 isoform X7

    See identical proteins and their annotated locations for XP_011238606.1

    UniProtKB/TrEMBL
    Q3TPI3
    Conserved Domains (5) summary
    smart00502
    Location:161 → 287
    BBC; B-Box C-terminal domain
    smart00557
    Location:325 → 421
    IG_FLMN; Filamin-type immunoglobulin domains
    cd14960
    Location:471 → 748
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    cd16767
    Location:20 → 65
    RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
    cd19824
    Location:115 → 156
    Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins

  14. XM_030252919.2 → XP_030108779.1  tripartite motif-containing protein 2 isoform X8

    UniProtKB/Swiss-Prot
    Q3UHP5, Q5DU27, Q8C981, Q9ESN6
    UniProtKB/TrEMBL
    Q3TPI3
    Related
    ENSMUSP00000103321.3, ENSMUST00000107693.9
    Conserved Domains (5) summary
    smart00502
    Location:161 → 287
    BBC; B-Box C-terminal domain
    smart00557
    Location:325 → 421
    IG_FLMN; Filamin-type immunoglobulin domains
    cd14960
    Location:471 → 744
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    cd16767
    Location:20 → 65
    RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
    cd19824
    Location:115 → 156
    Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins

  15. XM_036163422.1 → XP_036019315.1  tripartite motif-containing protein 2 isoform X7

    UniProtKB/TrEMBL
    Q3TPI3
    Conserved Domains (5) summary
    smart00502
    Location:161 → 287
    BBC; B-Box C-terminal domain
    smart00557
    Location:325 → 421
    IG_FLMN; Filamin-type immunoglobulin domains
    cd14960
    Location:471 → 748
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    cd16767
    Location:20 → 65
    RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
    cd19824
    Location:115 → 156
    Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins

  16. XM_011240303.4 → XP_011238605.1  tripartite motif-containing protein 2 isoform X7

    See identical proteins and their annotated locations for XP_011238605.1

    UniProtKB/TrEMBL
    Q3TPI3
    Conserved Domains (5) summary
    smart00502
    Location:161 → 287
    BBC; B-Box C-terminal domain
    smart00557
    Location:325 → 421
    IG_FLMN; Filamin-type immunoglobulin domains
    cd14960
    Location:471 → 748
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    cd16767
    Location:20 → 65
    RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
    cd19824
    Location:115 → 156
    Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins

  17. XM_011240305.1 → XP_011238607.1  tripartite motif-containing protein 2 isoform X10

    Conserved Domains (4) summary
    smart00502
    Location:161 → 235
    BBC; B-Box C-terminal domain
    cd00162
    Location:23 → 63
    RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
    cl00034
    Location:115 → 156
    Bbox_SF; B-box-type zinc finger superfamily
    cl17238
    Location:20 → 65
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ESN6.1 GenPept UniProtKB/Swiss-Prot:Q9ESN6

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