YEATS4 YEATS domain containing 4 [Homo sapiens] - Gene

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Summary

Official Symbol: YEATS4provided by HGNC
Official Full Name: YEATS domain containing 4provided by HGNC
Primary source: HGNC:24859
See related: Ensembl:ENSG00000127337; HPRD:03666; MIM:602116; Vega:OTTHUMG00000169358
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: YAF9; GAS41; NUBI-1; 4930573H17Rik; B230215M10Rik
Summary: The protein encoded by this gene is found in the nucleoli. It has high sequence homology to human MLLT1, and yeast and human MLLT3 proteins. Both MLLT1 and MLLT3 proteins belong to a class of transcription factors, indicating that the encoded protein might also represent a transcription factor. This protein is thought to be required for RNA transcription. This gene has been shown to be amplified in tumors. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 12q13-q15

Sequence :: Chromosome: 12; NC_000012.11 (69753532..69784576)

See YEATS4 in Epigenomics, MapViewer

Chromosome 12 - NC_000012.11 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Gas41 is able to bind both n-Myc and c-Myc proteins, and that the levels of expression of Gas41 and Myc proteins were similar to each other in such brain tumors as neuroblastomas and glioblastomas.
Title: Direct interaction of Gas41 and Myc encoded by amplified genes in nervous system tumours.
The GAS41-PP2Cbeta complex dephosphorylates p53 at serine 366 and regulates its stability
Title: The GAS41-PP2Cbeta complex dephosphorylates p53 at serine 366 and regulates its stability.
The in vivo interaction of GAS41 and endogenous RAP30 and RAP74 was confirmed by co-immunoprecipitation. GAS41 binds to two non-overlapping regions of the C-terminus of RAP30.
Title: The YEATS family member GAS41 interacts with the general transcription factor TFIIF.
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Genomic association analysis suggests chromosome 12 locus influencing antihypertensive response to thiazide diuretic.
Overexpression of YEATS4 is associated with well-differentiated and dedifferentiated liposarcomas
Title: HMGA2 is the partner of MDM2 in well-differentiated and dedifferentiated liposarcomas whereas CDK4 belongs to a distinct inconsistent amplicon.
Interaction of the transforming acidic coiled-coil 1 (TACC1) protein with ch-TOG and GAS41/NuBI1 suggests multiple TACC1-containing protein complexes in human cells
Title: Interaction of the transforming acidic coiled-coil 1 (TACC1) protein with ch-TOG and GAS41/NuBI1 suggests multiple TACC1-containing protein complexes in human cells.
GAS41 plays a role in repressing the p53 tumor suppressor pathway during the normal cell cycle by a TIP60-independent mechanism.
Title: GAS41 is required for repression of the p53 tumor suppressor pathway during normal cellular proliferation.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

Many sequence variants affecting diversity of adult human height.

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Products	Interactant	Other Gene	Source	Pubs	Description
O95619	Q9NV56	C20orf20	HPRD	PubMed
O95619	P55197	MLLT10	HPRD	PubMed
O95619	Q14980	NUMA1	HPRD	PubMed
O95619	O60925	PFDN1	HPRD	PubMed
O95619	Q12824	SMARCB1	HPRD	PubMed
O95619	O75410	TACC1	HPRD	PubMed
O95619	O95359	TACC2	HPRD	PubMed
O95619	Q92481	TFAP2B	HPRD	PubMed
BioGRID:113761	BioGRID:120548	C20orf20	BioGRID	PubMed	Affinity Capture-MS
BioGRID:113761	BioGRID:121004	DMAP1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:113761	BioGRID:120041	ING3	BioGRID	PubMed	Affinity Capture-MS
BioGRID:113761	BioGRID:115779	KAT5	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:113761	BioGRID:116506	KIAA1009	BioGRID	PubMed	Two-hybrid
BioGRID:113761	BioGRID:113723	MLLT10	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:113761	BioGRID:110980	NUMA1	BioGRID	PubMed	Reconstituted Complex; Two-hybrid
BioGRID:113761	BioGRID:111223	PFDN1	BioGRID	PubMed	Two-hybrid
BioGRID:113761	BioGRID:114166	RUVBL1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:113761	BioGRID:116067	RUVBL2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:113761	BioGRID:112482	SMARCB1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:113761	BioGRID:112730	TACC1	BioGRID	PubMed	Affinity Capture-Western; Two-hybrid
BioGRID:113761	BioGRID:115830	TACC2	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:113761	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS
BioGRID:113761	BioGRID:1205541	tat	BioGRID	PubMed	Reconstituted Complex

Function	Evidence Code	Pubs
DNA binding	TAS Traceable Author Statement more info	PubMed
protein C-terminus binding	IPI Inferred from Physical Interaction more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed
sequence-specific DNA binding transcription factor activity	TAS Traceable Author Statement more info	PubMed
structural constituent of cytoskeleton	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
chromatin modification	IEA Inferred from Electronic Annotation more info
histone H2A acetylation	IDA Inferred from Direct Assay more info	PubMed
histone H4 acetylation	IDA Inferred from Direct Assay more info	PubMed
mitosis	NAS Non-traceable Author Statement more info	PubMed
positive regulation of transcription, DNA-dependent	NAS Non-traceable Author Statement more info	PubMed
regulation of growth	IEA Inferred from Electronic Annotation more info
regulation of transcription, DNA-dependent	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
NuA4 histone acetyltransferase complex	IDA Inferred from Direct Assay more info	PubMed
nuclear matrix	NAS Non-traceable Author Statement more info	PubMed
nucleoplasm	IDA Inferred from Direct Assay more info	PubMed
nucleus	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: YEATS domain-containing protein 4

Names: YEATS domain-containing protein 4; nuBI1; NuMA binding protein 1; nuMA-binding protein 1; glioma-amplified sequence 41; glioma-amplified sequence-41

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_006530.2 → NP_006521.1 YEATS domain-containing protein 4

Status: REVIEWED

Source sequence(s)

U61384

Consensus CDS

CCDS8990.1

UniProtKB/Swiss-Prot

O95619

Related

ENSP00000247843, OTTHUMP00000240879, ENST00000247843, OTTHUMT00000403663

Conserved Domains (1) summary

pfam03366
Location:44 – 126
Blast Score: 284

YEATS; YEATS family

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000012.11 Reference GRCh37.p5 Primary Assembly

Range

69753532..69784576

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000144.1 Alternate HuRef

Range

66803053..66834103

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC117502.4 (6855..37899)	None
genomic	CH471054.1	EAW97223.1
		EAW97224.1
mRNA	AJ245746.1	CAC01935.1
mRNA	AK001413.1	BAA91678.1
mRNA	BC000994.2	AAH00994.1
mRNA	U61384.1	AAD12188.1
other-genetic	EU446926.1	ABZ92455.1