TAS1R2 taste receptor, type 1, member 2 [Homo sapiens] - Gene

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Summary

Official Symbol: TAS1R2provided by HGNC
Official Full Name: taste receptor, type 1, member 2provided by HGNC
Primary source: HGNC:14905
See related: Ensembl:ENSG00000179002; HPRD:06940; MIM:606226; Vega:OTTHUMG00000002442
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: TR2; T1R2; GPR71

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Genomic context

Location :: 1p36.13

Sequence :: Chromosome: 1; NC_000001.10 (19166093..19186155, complement)

See TAS1R2 in Epigenomics, MapViewer

Chromosome 1 - NC_000001.10 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Genetic ablation of the sweet TR protein T1R2 obliterates fructose-induced insulin release and its potentiating effects on glucose-stimulated insulin secretion in vitro and in vivo.
Title: Sweet taste receptor signaling in beta cells mediates fructose-induced potentiation of glucose-stimulated insulin secretion.
T1R2/T1R3 is involved in glucose-dependent secretion of satiation peptides
Title: The role of the gut sweet taste receptor in regulating GLP-1, PYY, and CCK release in humans.
Our findings show that a genetic variation in TAS1R2 affects habitual consumption of sugars and may contribute to interindividual differences in changing behaviors in response to dietary counseling.
Title: Genetic variation in TAS1R2 (Ile191Val) is associated with consumption of sugars in overweight and obese individuals in 2 distinct populations.
significant associations were seen in TAS1R2 for caries risk and/or protection.
Title: Taste genes associated with dental caries.
Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variation in TAS1R2 (Ile191Val) is associated with consumption of sugars in overweight and obese individuals in 2 distinct populations.
Data show that Positive allosteric modulators of the sweet taste receptor could help reduce the caloric content in food and beverages while maintaining the desired taste.
Title: Positive allosteric modulators of the human sweet taste receptor enhance sweet taste.
Results from mutagenesis and chimeras of the receptor indicated that brazzein interacts with both T1R2 and T1R3 and that the Venus flytrap module of T1R2 is important for brazzein agonism.
Title: Key amino acid residues involved in multi-point binding interactions between brazzein, a sweet protein, and the T1R2-T1R3 human sweet receptor.
Interactions between the human sweet-sensing T1R2-T1R3 receptor and sweeteners detected by saturation transfer difference NMR spectroscopy.
Title: Interactions between the human sweet-sensing T1R2-T1R3 receptor and sweeteners detected by saturation transfer difference NMR spectroscopy.
Some of the amino acid positions crucial for activation of hTAS1R2+hTAS1R3 by neohesperidin dihydrochalcone are involved in the binding of allosteric modulators in other class C GPCRs
Title: The binding site for neohesperidin dihydrochalcone at the human sweet taste receptor.
sweet and umami taste are strictly dependent on T1R-receptors, and show that selective elimination of T1R-subunits differentially abolishes detection and perception of these two taste modalities
Title: The receptors for mammalian sweet and umami taste.

Submit: New GeneRIF Correction See all (12)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

Genome-wide association study confirms SNPs in SNCA and the MAPT region as common risk factors for Parkinson disease.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description
BioGRID:123327	BioGRID:123757	TAS1R3		BioGRID	PubMed	Affinity Capture-Western

Function	Evidence Code	Pubs
protein heterodimerization activity	NAS Non-traceable Author Statement more info	PubMed
receptor activity	IEA Inferred from Electronic Annotation more info
signal transducer activity	IEA Inferred from Electronic Annotation more info
contributes_to sweet taste receptor activity	IDA Inferred from Direct Assay more info	PubMed
taste receptor activity	IDA Inferred from Direct Assay more info	PubMed
contributes_to taste receptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
G-protein coupled receptor signaling pathway	IC Inferred by Curator more info	PubMed
detection of chemical stimulus involved in sensory perception of sweet taste	IDA Inferred from Direct Assay more info	PubMed
response to stimulus	IEA Inferred from Electronic Annotation more info
sensory perception of sweet taste	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
integral to membrane	IC Inferred by Curator more info	PubMed
plasma membrane	TAS Traceable Author Statement more info

General protein information

Preferred Names: taste receptor type 1 member 2

Names: taste receptor type 1 member 2; sweet taste receptor T1R2; G protein-coupled receptor 71; G-protein coupled receptor 71

NP_689418.2

EC 1.5.1.12

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_152232.2 → NP_689418.2 taste receptor type 1 member 2 precursor

Status: VALIDATED

Source sequence(s)

AL831755, BX537160

Consensus CDS

CCDS187.1

UniProtKB/Swiss-Prot

Q8TE23

Related

ENSP00000364520, OTTHUMP00000002543, ENST00000375371, OTTHUMT00000006953

Conserved Domains (5) summary

cd06363
Location:27 – 341
Blast Score: 1188

PBP1_Taste_receptor; Ligand-binding domain of the T1R taste receptor

pfam07562
Location:491 – 544
Blast Score: 201

NCD3G; Nine Cysteines Domain of family 3 GPCR

pfam00003
Location:575 – 815
Blast Score: 475

7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR

pfam01094
Location:70 – 454
Blast Score: 539

ANF_receptor; Receptor family ligand binding region

cl10011
Location:404 – 484
Blast Score: 305

Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000001.10 Reference GRCh37.p5 Primary Assembly

Range

19166093..19186155, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000133.1 Alternate HuRef

Range

17412422..17430320, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AF458154.1	AAM12239.1
genomic	AL831755.9	CAI17299.1
genomic	BX537160.6	CAH69954.1
genomic	CH471134.1	EAW94857.1
genomic	FB676145.1	CAS03501.1
genomic	FB701754.1	CAS03327.1
genomic	FB701764.1	CAS03332.1
mRNA	BK000151.1	DAA00019.1
other-genetic	BC141437.1	AAI41438.1