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CMIP c-Maf inducing protein [ Homo sapiens (human) ]

Gene ID: 80790, updated on 8-May-2016
Official Symbol
CMIPprovided by HGNC
Official Full Name
c-Maf inducing proteinprovided by HGNC
Primary source
HGNC:HGNC:24319
See related
Ensembl:ENSG00000153815 HPRD:10839; MIM:610112; Vega:OTTHUMG00000176520
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TCMIP
Summary
This gene encodes a c-Maf inducing protein that plays a role in T-cell signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
Orthologs
Location:
16q23
Exon count:
26
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 16 NC_000016.10 (81445170..81711762)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (81478775..81745367)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene gigaxonin Neighboring gene microRNA 4720 Neighboring gene peptidylprolyl isomerase A (cyclophilin A) pseudogene Neighboring gene microRNA 7854 Neighboring gene uncharacterized LOC105371362 Neighboring gene microRNA 6504 Neighboring gene uncharacterized LOC100129617 Neighboring gene uncharacterized LOC105369213 Neighboring gene phospholipase C gamma 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
A meta-analysis of genome-wide association studies for adiponectin levels in East Asians identifies a novel locus near WDR11-FGFR2.
NHGRI GWA Catalog
Biological, clinical and population relevance of 95 loci for blood lipids.
NHGRI GWA Catalog
Discovery and refinement of loci associated with lipid levels.
NHGRI GWA Catalog
Electronic medical records and genomics (eMERGE) network exploration in cataract: Several new potential susceptibility loci.
NHGRI GWA Catalog
Genome wide association study of age at menarche in the Japanese population.
NHGRI GWA Catalog
Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan.
NHGRI GWA Catalog
Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians.
NHGRI GWA Catalog
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • KIAA1694

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
C-Maf-inducing protein
Names
tc-Mip

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029839.1 RefSeqGene

    Range
    5001..271593
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_030629.2NP_085132.1  C-Maf-inducing protein isoform Tc-Mip

    See identical proteins and their annotated locations for NP_085132.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' terminal exon compared to variant 1. This results in a shorter isoform (Tc-Mip) with a distinct N-terminus compared to isoform C-Mip. This isoform lacks the NH2-terminal PH domain, is specifically recruited to PBMCs in MCNS patients, and thought to play a role in T-cell signaling pathway.
    Source sequence(s)
    AY172689, BM789770
    Consensus CDS
    CCDS54045.1
    UniProtKB/Swiss-Prot
    Q8IY22
    Related
    ENSP00000440401, OTTHUMP00000254464, ENST00000539778, OTTHUMT00000432400
    Conserved Domains (2) summary
    cd09293
    Location:500674
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:570593
    LRR_AMN1; leucine-rich repeat [structural motif]
  2. NM_198390.2NP_938204.2  C-Maf-inducing protein isoform C-Mip

    See identical proteins and their annotated locations for NP_938204.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (C-Mip). This variant is predominantly expressed in fetal liver, kidney, and peripheral blood mononuclear cells (PBMCs), but weakly detected in PBMCs from minimal change nephrotic syndrome (MCNS) patients.
    Source sequence(s)
    AB051481, BM789770, CV570964
    Consensus CDS
    CCDS54044.1
    UniProtKB/Swiss-Prot
    Q8IY22
    Related
    ENSP00000446100, OTTHUMP00000254463, ENST00000537098, OTTHUMT00000432399
    Conserved Domains (3) summary
    cd09293
    Location:594768
    AMN1; Antagonist of mitotic exit network protein 1
    pfam00169
    Location:71157
    PH; PH domain
    sd00034
    Location:664687
    LRR_AMN1; leucine-rich repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p2 Primary Assembly

    Range
    81445170..81711762
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011523352.1XP_011521654.1  

    See identical proteins and their annotated locations for XP_011521654.1

    Conserved Domains (3) summary
    cd00116
    Location:647755
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    pfam00169
    Location:71157
    PH; PH domain
    sd00034
    Location:648671
    LRR_AMN1; leucine-rich repeat [structural motif]
  2. XM_005256179.3XP_005256236.3  

    Conserved Domains (2) summary
    cd00116
    Location:607715
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00034
    Location:608631
    LRR_AMN1; leucine-rich repeat [structural motif]
  3. XM_005256181.2XP_005256238.1  

    See identical proteins and their annotated locations for XP_005256238.1

    UniProtKB/TrEMBL
    A0A087WU05
    Related
    ENSP00000478272, OTTHUMP00000275679, ENST00000566513, OTTHUMT00000432402
    Conserved Domains (2) summary
    cd09293
    Location:442581
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:477500
    LRR_AMN1; leucine-rich repeat [structural motif]
  4. XM_011523353.1XP_011521655.1  

    See identical proteins and their annotated locations for XP_011521655.1

    UniProtKB/TrEMBL
    A0A087WU05
    Related
    ENSP00000381120, OTTHUMP00000254465, ENST00000398040, OTTHUMT00000432404
    Conserved Domains (2) summary
    cd09293
    Location:442581
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:477500
    LRR_AMN1; leucine-rich repeat [structural motif]
  5. XM_005256182.1XP_005256239.1  

    See identical proteins and their annotated locations for XP_005256239.1

    UniProtKB/TrEMBL
    A0A087WU05
    Conserved Domains (2) summary
    cd09293
    Location:442581
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:477500
    LRR_AMN1; leucine-rich repeat [structural motif]

Alternate CHM1_1.1

Genomic

  1. NC_018927.2 Alternate CHM1_1.1

    Range
    82890152..83156504
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)