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TTYH3 tweety family member 3 [ Homo sapiens (human) ]

Gene ID: 80727, updated on 26-May-2016
Official Symbol
TTYH3provided by HGNC
Official Full Name
tweety family member 3provided by HGNC
Primary source
HGNC:HGNC:22222
See related
Ensembl:ENSG00000136295 HPRD:12333; MIM:608919; Vega:OTTHUMG00000152050
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the tweety family of proteins. Members of this family function as chloride anion channels. The encoded protein functions as a calcium(2+)-activated large conductance chloride(-) channel. [provided by RefSeq, Jul 2008]
Orthologs
Location:
7p22
Exon count:
16
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 7 NC_000007.14 (2631969..2664802)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (2671603..2704436)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene BRCA1 associated ATM activator 1 Neighboring gene IQ motif containing E Neighboring gene archaelysin family metallopeptidase 1 Neighboring gene G protein subunit alpha 12 Neighboring gene prefoldin subunit 4 pseudogene

NHGRI GWAS Catalog

Description
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • KIAA1691

Gene Ontology Provided by GOA

Process Evidence Code Pubs
chloride transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
chloride transport IDA
Inferred from Direct Assay
more info
PubMed 
ion transmembrane transport TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
chloride channel complex IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
protein tweety homolog 3
Names
hTTY3
tweety homolog 3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025250.2NP_079526.1  protein tweety homolog 3

    See identical proteins and their annotated locations for NP_079526.1

    Status: REVIEWED

    Source sequence(s)
    AB051478, AF318350, AK074158, AK124608, AL522452, BC041603, BC069027
    Consensus CDS
    CCDS34588.1
    UniProtKB/Swiss-Prot
    Q9C0H2
    UniProtKB/TrEMBL
    A0A024R816, Q8WYU9
    Related
    ENSP00000258796, OTTHUMP00000201106, ENST00000258796, OTTHUMT00000325082
    Conserved Domains (1) summary
    cd07912
    Location:5421
    Tweety_N; N-terminal domain of the protein encoded by the Drosophila tweety gene and related proteins, a family of chloride ion channels

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p2 Primary Assembly

    Range
    2631969..2664802
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011515536.1XP_011513838.1  

    Conserved Domains (1) summary
    cd07912
    Location:5419
    Tweety_N; N-terminal domain of the protein encoded by the Drosophila tweety gene and related proteins, a family of chloride ion channels
  2. XM_011515535.1XP_011513837.1  

    UniProtKB/Swiss-Prot
    Q9C0H2
    Conserved Domains (1) summary
    cd07912
    Location:5421
    Tweety_N; N-terminal domain of the protein encoded by the Drosophila tweety gene and related proteins, a family of chloride ion channels

Alternate CHM1_1.1

Genomic

  1. NC_018918.2 Alternate CHM1_1.1

    Range
    2671274..2704022
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)