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    TTYH3 tweety homolog 3 (Drosophila) [ Homo sapiens ]

    Gene ID: 80727, updated on 11-May-2012
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    Summary

    Official Symbol
    TTYH3provided by HGNC
    Official Full Name
    tweety homolog 3 (Drosophila)provided by HGNC
    Primary source
    HGNC:22222
    See related
    Ensembl:ENSG00000136295; HPRD:12333; MIM:608919; Vega:OTTHUMG00000152050
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KIAA1691
    Summary
    This gene encodes a member of the tweety family of proteins. Members of this family function as chloride anion channels. The encoded protein functions as a calcium(2+)-activated large conductance chloride(-) channel. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    7p22
    Sequence :
    Chromosome: 7; NC_000007.13 (2671603..2704436)
    See TTYH3 in Epigenomics, MapViewer

    Chromosome 7 - NC_000007.13Genomic Context describing neighboring genes Neighboring gene BRCA1-associated ATM activator 1 Neighboring gene IQ motif containing E Neighboring gene archaelysin family metallopeptidase 1 Neighboring gene guanine nucleotide binding protein (G protein) alpha 12 Neighboring gene prefoldin subunit 4 pseudogene

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. Lee KA, et al. J Biol Chem, 2011 Dec 2. PMID 21987572.
    2. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    3. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    4. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048.
    5. Protein interaction data set highlighted with human Ras-MAPK/PI3K signaling pathways. Wang J, et al. J Proteome Res, 2008 Sep. PMID 18624398.

    See all (10) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Nedd4-2 differentially interacts with and regulates TTYH1-3
      Title: The ubiquitin-protein ligase Nedd4-2 differentially interacts with and regulates members of the Tweety family of chloride ion channels.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:123277 BioGRID:111581 MAPK3    BioGRID  PubMed Two-hybrid 
    BioGRID:123277 BioGRID:110811 NEDD4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:123277 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
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    General gene information

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    chloride channel activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    chloride transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    chloride channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    integral to membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    protein tweety homolog 3
    Names
    protein tweety homolog 3
    hTTY3
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025250.2 → NP_079526.1  protein tweety homolog 3

      Status: REVIEWED

      Source sequence(s)
      AB051478, AF318350, AK074158, AK124608, AL522452, BC041603, BC069027
      Consensus CDS
      CCDS34588.1
      UniProtKB/TrEMBL
      Q8WYU9
      UniProtKB/Swiss-Prot
      Q9C0H2
      Related
      ENSP00000258796, OTTHUMP00000201106, ENST00000258796, OTTHUMT00000325082
      Conserved Domains (1) summary
      cd07912
      Location:5 – 421
      Blast Score: 1267
      Tweety_N; N-terminal domain of the protein encoded by the Drosophila tweety gene and related proteins, a family of chloride ion channels.

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000007.13 Reference GRCh37.p5 Primary Assembly

      Range
      2671603..2704436
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000139.1 Alternate HuRef

      Range
      2589841..2622726
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CRA_TCAGchr7v2

    Genomic

    1. AC_000068.1 Alternate CRA_TCAGchr7v2

      Range
      2719442..2752317
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC006028.3 (196584..210607) None
    genomic AC073462.8 (200..19009) None
    genomic CH236953.1 EAL23958.1
    genomic CH471144.1 EAW87265.1
      EAW87266.1
      EAW87267.1
      EAW87268.1
    mRNA AB051478.2 BAB21782.2
    mRNA AB162931.1 BAD20190.1
    mRNA AF318350.1 AAL55857.1
    mRNA AK074158.1 BAB84984.1
    mRNA AK096851.1 None
    mRNA AK124608.1 BAC85898.1
    mRNA AL522452.3 None
    mRNA AL833825.1 CAH10666.1
    mRNA BC041603.1 None
    mRNA BC069027.1 None
    mRNA BC131824.1 AAI31825.1
    mRNA BC152447.1 AAI52448.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q69YH1 GenPept UniProtKB/TrEMBL:Q69YH1
    Q8WYU9 GenPept UniProtKB/TrEMBL:Q8WYU9
    Q9C0H2.3 GenPept UniProtKB/Swiss-Prot:Q9C0H2
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    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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