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SRCIN1 SRC kinase signaling inhibitor 1 [ Homo sapiens (human) ]

Gene ID: 80725, updated on 26-May-2016
Official Symbol
SRCIN1provided by HGNC
Official Full Name
SRC kinase signaling inhibitor 1provided by HGNC
Primary source
HGNC:HGNC:29506
See related
Ensembl:ENSG00000277363 HPRD:11589; MIM:610786; Vega:OTTHUMG00000188493
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P140; SNIP
Orthologs
Location:
17q12
Exon count:
19
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 17 NC_000017.11 (38530024..38605930, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (36686259..36762183, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene suppressor of cytokine signaling 7 Neighboring gene Rho GTPase activating protein 23 Neighboring gene uncharacterized LOC101929494 Neighboring gene uncharacterized LOC105371761 Neighboring gene uncharacterized LOC105371764 Neighboring gene chromosome 17 open reading frame 96 Neighboring gene uncharacterized LOC105371763 Neighboring gene microRNA 4734

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • KIAA1684

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IEA
Inferred from Electronic Annotation
more info
 
protein kinase binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
exocytosis IEA
Inferred from Electronic Annotation
more info
 
negative regulation of protein secretion IEA
Inferred from Electronic Annotation
more info
 
negative regulation of protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of dendritic spine morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
substrate adhesion-dependent cell spreading IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
actin cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
axon ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
dendrite ISS
Inferred from Sequence or Structural Similarity
more info
 
filopodium IEA
Inferred from Electronic Annotation
more info
 
NOT focal adhesion IDA
Inferred from Direct Assay
more info
PubMed 
lamellipodium IEA
Inferred from Electronic Annotation
more info
 
neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
postsynaptic density ISS
Inferred from Sequence or Structural Similarity
more info
 
postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
synapse ISS
Inferred from Sequence or Structural Similarity
more info
 
Preferred Names
SRC kinase signaling inhibitor 1
Names
P130Cas-associated protein
SNAP-25-interacting protein
SNAP25-interacting protein
p140Cap

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025248.2NP_079524.2  SRC kinase signaling inhibitor 1

    See identical proteins and their annotated locations for NP_079524.2

    Status: VALIDATED

    Source sequence(s)
    AC006449, AC115090, AC129916
    Consensus CDS
    CCDS45660.1
    UniProtKB/Swiss-Prot
    Q9C0H9
    Related
    ENSP00000484715, OTTHUMP00000276712, ENST00000617146, OTTHUMT00000477418
    Conserved Domains (2) summary
    smart00806
    Location:184255
    AIP3; Actin interacting protein 3
    TIGR02169
    Location:686840
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p2 Primary Assembly

    Range
    38530024..38605930 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p2 ALT_REF_LOCI_1

Genomic

  1. NT_187614.1 Reference GRCh38.p2 ALT_REF_LOCI_1

    Range
    2565325..2641249 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018928.2 Alternate CHM1_1.1

    Range
    36921587..36997493 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)