Sign in to NCBI

Display Settings:

Format

Send to:

Choose Destination
We are sorry, but NCBI web applications do not support your browser and may not function properly. More information

    UBXN6 UBX domain protein 6 [ Homo sapiens (human) ]

    Gene ID: 80700, updated on 5-May-2013
    Official Symbol
    UBXN6provided by HGNC
    Official Full Name
    UBX domain protein 6provided by HGNC
    Primary source
    HGNC:14928
    See related
    Ensembl:ENSG00000167671; HPRD:18253; MIM:611946; Vega:OTTHUMG00000181954
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    UBXD1; UBXDC2
    Location :
    19p13
    Sequence :
    Chromosome: 19; NC_000019.9 (4445003..4457791, complement)
    See UBXN6 in Epigenomics, MapViewer

    Chromosome 19 - NC_000019.9Genomic Context describing neighboring genes Neighboring gene SH3-domain GRB2-like 1 Neighboring gene chromatin assembly factor 1, subunit A (p150) Neighboring gene microRNA 4746 Neighboring gene uncharacterized LOC100996367 Neighboring gene hepatoma-derived growth factor-related protein 2 Neighboring gene perilipin 4

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells. Yu CC, et al. PLoS One, 2013. PMID 23383273.
    2. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. Cloutier P, et al. PLoS Genet, 2013 Jan. PMID 23349634.
    3. Ubiquitination of the N-terminal region of caveolin-1 regulates endosomal sorting by the VCP/p97 AAA-ATPase. Kirchner P, et al. J Biol Chem, 2013 Mar 8. PMID 23335559.
    4. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. Povlsen LK, et al. Nat Cell Biol, 2012 Oct. PMID 23000965.
    5. A census of human soluble protein complexes. Havugimana PC, et al. Cell, 2012 Aug 31. PMID 22939629.

    See all (28) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Data indicate that endosomal trafficking of CAV1 depends on ubiquitination of the N-terminal region and the subsequent recruitment of VCP-UBXD1.
      Title: Ubiquitination of the N-terminal region of caveolin-1 regulates endosomal sorting by the VCP/p97 AAA-ATPase.
    2. UBXD1 modulates the trafficking of ERGIC-53-containing vesicles by controlling the interaction of transport factors with the cytoplasmic tail of ERGIC-53.
      Title: Protein interaction profiling of the p97 adaptor UBXD1 points to a role for the complex in modulating ERGIC-53 trafficking.
    3. Data show that expression of VCP mutant proteins, or siRNA-mediated depletion of UBXD1 leads to a block of CAV1 transport at the limiting membrane of enlarged endosomes in cultured cells.
      Title: Endolysosomal sorting of ubiquitylated caveolin-1 is regulated by VCP and UBXD1 and impaired by VCP disease mutations.
    4. these findings suggest that UBXD1 is a regulatory component of endoplasmic reticulum-associated degradation that may modulate the adaptor binding to VCP.
      Title: UBXD1 is a VCP-interacting protein that is involved in ER-associated degradation.
    5. An additional p97 binding site in UBXD1 that competed with the p47 cofactor for binding to the N domain of p97 was identified.
      Title: UBXD1 binds p97 through two independent binding sites.
    6. UBXD1 is a novel co-factor of the human p97 ATPase.
      Title: Ubxd1 is a novel co-factor of the human p97 ATPase.
    Submit: New GeneRIF Correction

    Review eQTL and phenotype association data in this region using PheGenI

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:123263 BioGRID:106751 ALPP    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123263 BioGRID:106848 APP    BioGRID  PubMed Reconstituted Complex 
    BioGRID:123263 BioGRID:122516 ASPSCR1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123263 BioGRID:107271 CANX    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123263 BioGRID:107305 CAV1    BioGRID  PubMed Affinity Capture-Western; Co-localization 
    BioGRID:123263 BioGRID:115933 CCT8    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123263 BioGRID:107709 COPA    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123263 BioGRID:122559 DERL1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:123263 BioGRID:107135 DST    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123263 BioGRID:108238 EEF1A2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123263 BioGRID:108309 ELAVL1    BioGRID  PubMed Affinity Capture-RNA 
    BioGRID:123263 BioGRID:116806 FAF2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123263 BioGRID:115506 FLOT1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123263 BioGRID:109187 GSK3B    BioGRID  PubMed Two-hybrid 
    BioGRID:123263 BioGRID:109433 HNRNPU    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123263 BioGRID:109535 HSPA1A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123263 BioGRID:114048 IRS4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123263 BioGRID:119559 LIMA1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123263 BioGRID:110185 LMAN1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:123263 BioGRID:124712 MCFD2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123263 BioGRID:122744 METTL21D    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123263 BioGRID:120798 NPLOC4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123263 BioGRID:111577 PRKDC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123263 BioGRID:111681 PSMD2    BioGRID  PubMed Affinity Capture-Western; Co-fractionation; Reconstituted Complex 
    BioGRID:123263 BioGRID:112102 RPS3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123263 BioGRID:114166 RUVBL1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123263 BioGRID:116067 RUVBL2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123263 BioGRID:116015 SEPT9    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123263 BioGRID:113500 TRIM25    BioGRID  PubMed Co-fractionation 
    BioGRID:123263 BioGRID:124259 TUBA1C    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123263 BioGRID:124148 TUBB6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123263 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Co-purification 
    BioGRID:123263 BioGRID:113200 UFD1L    BioGRID  PubMed Reconstituted Complex 
    BioGRID:123263 BioGRID:121217 UGGT1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123263 BioGRID:113258 VCP    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:123263 BioGRID:123125 VCPIP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123263 BioGRID:116925 VPS39    BioGRID  PubMed Co-fractionation 
    BioGRID:123263 BioGRID:116821 XPO6    BioGRID  PubMed Co-fractionation 
    BioGRID:123263 BioGRID:116866 ZC3H7B    BioGRID  PubMed Co-fractionation 
    • Protein processing in endoplasmic reticulum, organism-specific biosystem (from KEGG)
      Protein processing in endoplasmic reticulum, organism-specific biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
    • Protein processing in endoplasmic reticulum, conserved biosystem (from KEGG)
      Protein processing in endoplasmic reticulum, conserved biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...

    Markers

    Genotypes

    Homology

    Clone Names

    • FLJ00394, DKFZp667D109

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    molecular_function ND
    No biological Data available
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    cellular_component ND
    No biological Data available
    more info
    		  
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    microtubule organizing center IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleolus IDA
    Inferred from Direct Assay
    more info
    		  
    nucleus IDA
    Inferred from Direct Assay
    more info
    		  
    Preferred Names
    UBX domain-containing protein 6
    Names
    UBX domain-containing protein 6
    UBX domain containing 1
    UBX domain-containing 1
    UBX domain-containing 2
    UBX domain-containing protein 1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001171091.1 → NP_001164562.1  UBX domain-containing protein 6 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate 5' exon, resulting in a downstream in-frame AUG start codon, as compared to variant 1. The resulting isoform (2) is shorter than isoform 1 at the N-terminus.
      Source sequence(s)
      AF272894, BC007414, BC008288
      Consensus CDS
      CCDS54201.1
      UniProtKB/Swiss-Prot
      Q9BZV1
      Related
      ENSP00000378246, OTTHUMP00000267975, ENST00000394765, OTTHUMT00000458450
      Conserved Domains (2) summary
      cd10460
      Location:105 – 210
      Blast Score: 400
      PUB_UBXD1; PNGase/UBA or UBX (PUB) domain of UBXD1
      cl00155
      Location:281 – 354
      Blast Score: 131
      UBQ; Ubiquitin-like proteins

    2. NM_025241.2 → NP_079517.1  UBX domain-containing protein 6 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      BC007414, BC008288, BM764980
      Consensus CDS
      CCDS12129.1
      UniProtKB/Swiss-Prot
      Q9BZV1
      Related
      ENSP00000301281, OTTHUMP00000267974, ENST00000301281, OTTHUMT00000458447
      Conserved Domains (2) summary
      cd10460
      Location:158 – 263
      Blast Score: 400
      PUB_UBXD1; PNGase/UBA or UBX (PUB) domain of UBXD1
      cl00155
      Location:334 – 407
      Blast Score: 131
      UBQ; Ubiquitin-like proteins

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000019.9 Reference GRCh37.p10 Primary Assembly

      Range
      4445003..4457791, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000151.1 Alternate HuRef

      Range
      4207464..4220339, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018930.1 Alternate CHM1_1.0

      Range
      4368889..4379168, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    genomic ABBA01056072.1 (3183..3349) None
    genomic ABBA01056073.1 None
    genomic AC011498.7 (76901..89430) None
    genomic AMYH01009333.1 (17573..27852) None
    genomic CH471139.2 EAW69219.1
      EAW69220.1
      EAW69221.1
      EAW69222.1
      EAW69223.1
    mRNA AF272893.1 AAK13257.1
    mRNA AF272894.1 AAK13258.1
    mRNA AK090473.1 BAC03454.1
    mRNA AL833695.1 None
    mRNA BC007414.2 AAH07414.2
    mRNA BC008288.1 AAH08288.1
    mRNA BC017113.1 AAH17113.1
    mRNA BM764980.1 None
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9BZV1.1 GenPept UniProtKB/Swiss-Prot:Q9BZV1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Related information

      • Order cDNA clone
        Order cDNA clone
      • BioAssay
        Related PubChem BioAssays
      • BioProjects
        BioProjects related to a gene
      • BioSystems
        BioSystems
      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • dbVar
        Link from Gene to dbVar
      • EST
        Link to related EST entry
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • Nucleotide
        Link to related Nucleotide entry
      • OMIM
        Links between OMIM and Gene are calculated by Gene based on MIM numbers included in the summary and phenotype sections of the Gene record.
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed (OMIM)
        Links are provided when Gene has a link to a record in OMIM, and OMIM explicitly cites these publications in PubMed.
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
      • SNP: Genotype
        Gene Genotype Report
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

      Links to other resources

      General information

      Related sites

      Feedback

      Subscription

      Recent activity

      Clear Turn Off Turn On

      Your browsing activity is empty.

      Activity recording is turned off.

      Turn recording back on

      See more...