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CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein) [ Homo sapiens (human) ]

Gene ID: 8048, updated on 21-Oct-2014
Official Symbol
CSRP3provided by HGNC
Official Full Name
cysteine and glycine-rich protein 3 (cardiac LIM protein)provided by HGNC
Primary source
HGNC:HGNC:2472
See related
Ensembl:ENSG00000129170; HPRD:07525; MIM:600824; Vega:OTTHUMG00000166100
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CLP; MLP; CRP3; LMO4; CMD1M; CMH12
Summary
This gene encodes a member of the CSRP family of LIM domain proteins, which may be involved in regulatory processes important for development and cellular differentiation. The LIM/double zinc-finger motif found in this protein is found in a group of proteins with critical functions in gene regulation, cell growth, and somatic differentiation. Mutations in this gene are thought to cause heritable forms of hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM) in humans. Alternatively spliced transcript variants with different 5' UTR, but encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]
See CSRP3 in Epigenomics, MapViewer
Location:
11p15.1
Exon count:
8
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 11 NC_000011.10 (19182030..19210571, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (19203577..19232118, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene MAS-related GPR, member X2 Neighboring gene zinc finger, DHHC-type containing 13 Neighboring gene E2F transcription factor 8 Neighboring gene proliferating cell nuclear antigen pseudogene 4

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC14488, MGC61993

Gene Ontology Provided by GOA

Function Evidence Code Pubs
actinin binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
structural constituent of muscle IMP
Inferred from Mutant Phenotype
more info
PubMed 
telethonin binding IDA
Inferred from Direct Assay
more info
PubMed 
telethonin binding IPI
Inferred from Physical Interaction
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cardiac muscle contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
cardiac muscle hypertrophy IMP
Inferred from Mutant Phenotype
more info
PubMed 
cardiac muscle tissue development ISS
Inferred from Sequence or Structural Similarity
more info
 
cardiac myofibril assembly ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
cellular calcium ion homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
detection of muscle stretch IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein localization to organelle IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of the force of heart contraction ISS
Inferred from Sequence or Structural Similarity
more info
 
skeletal muscle tissue development TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
Z disc IDA
Inferred from Direct Assay
more info
PubMed 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
cysteine and glycine-rich protein 3
Names
cysteine and glycine-rich protein 3
LIM domain only 4
cardiac LIM domain protein
muscle lim protein isoform

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011932.2 

    Range
    5003..33544
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_440

mRNA and Protein(s)

  1. NM_003476.4NP_003467.1  cysteine and glycine-rich protein 3

    See proteins identical to NP_003467.1

    Status: REVIEWED

    Source sequence(s)
    AA192614, AC009652, AJ711422, BC024010
    Consensus CDS
    CCDS7848.1
    UniProtKB/TrEMBL
    A2TDB8
    UniProtKB/Swiss-Prot
    P50461
    Related
    ENSP00000431813, OTTHUMP00000235874, ENST00000533783, OTTHUMT00000394484
    Conserved Domains (2) summary
    cd09481
    Location:962
    LIM1_CRP3; The first LIM domain of Cysteine Rich Protein 3 (CRP3/MLP)
    cd09482
    Location:120173
    LIM2_CRP3; The second LIM domain of Cysteine Rich Protein 3 (CRP3/MLP)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000011.10 

    Range
    19182030..19210571
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006718339.1XP_006718402.1  

    Conserved Domains (2) summary
    cd09481
    Location:53106
    LIM1_CRP3; The first LIM domain of Cysteine Rich Protein 3 (CRP3/MLP)
    cd09482
    Location:164217
    LIM2_CRP3; The second LIM domain of Cysteine Rich Protein 3 (CRP3/MLP)

Alternate HuRef

Genomic

  1. AC_000143.1 

    Range
    18887548..18916047
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018922.2 

    Range
    19202919..19231414
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)