PDCD1LG2 programmed cell death 1 ligand 2 [Homo sapiens] - Gene

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Summary

Official Symbol: PDCD1LG2provided by HGNC
Official Full Name: programmed cell death 1 ligand 2provided by HGNC
Primary source: HGNC:18731
See related: Ensembl:ENSG00000197646; HPRD:16147; MIM:605723; Vega:OTTHUMG00000019504
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: B7DC; Btdc; PDL2; CD273; PD-L2; PDCD1L2; bA574F11.2; MGC142238; MGC142240

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Genomic context

Location :: 9p24.2

Sequence :: Chromosome: 9; NC_000009.11 (5510545..5571282)

See PDCD1LG2 in Epigenomics, MapViewer

Chromosome 9 - NC_000009.11 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data suggest that brain endothelial cells contribute to control T cell transmigration into the CNS and immune responses via PD-L2 but not PD-L1 expression.
Title: Human brain endothelial cells endeavor to immunoregulate CD8 T cells via PD-1 ligand expression in multiple sclerosis.
increased expression of PD-L2, as a costimulatory molecule, may have an important modulatory function on the local immune responses of OLP in vivo.
Title: The high expression level of programmed death-1 ligand 2 in oral lichen planus and the possible costimulatory effect on human T cells.
Data suggest that PD-L1 may contribute to negative regulation of the immune response in chronic hepatitis B, and that PD-1 and PD-L1 and 2 may play a role in immune evasion of tumors.
Title: Immunostaining of PD-1/PD-Ls in liver tissues of patients with hepatitis and hepatocellular carcinoma.
Our results suggest that PD-1 G-536A, PD-L1 A8923C and PD-L2 C47103T polymorphisms are associated with the presence of ankylosing spondylitis.
Title: Effects of genetic polymorphisms of programmed cell death 1 and its ligands on the development of ankylosing spondylitis.
These observations indicate that PD-L2 is expressed following activation and is involved in the regulation of T cell function
Title: PD-L2 is expressed on activated human T cells and regulates their function.
REVIEW: role of PD-L1 and PD-L2 and ligands in allergic disease and asthma.
Title: Role of PD-L1 and PD-L2 in allergic diseases and asthma.
Findings demonstrate that the pretreatment of tumor cells with IFN-gamma enhances B7-DC expression through ERK and JNK pathways.
Title: Involvement of ERK and JNK pathways in IFN-γ-induced B7-DC expression on tumor cells.
Results suggest that over-expression of PD-1, PD-L1 and PD-L2 within liver may participate in local immune dysfunction, which could be one of the mechanisms involved in the chronicity of HBV infection and chronic inflammation seen in CHB patients.
Title: Intrahepatic levels of PD-1/PD-L correlate with liver inflammation in chronic hepatitis B.
PD-L1 and PD-L2 knockdown dendritic cells showed superior potential to expand minor histocompatibility antigen-specific CD8(+) effector and memory T cells from leukemia patients early after donor lymphocyte infusion and later during relapse.
Title: siRNA silencing of PD-L1 and PD-L2 on dendritic cells augments expansion and function of minor histocompatibility antigen-specific CD8+ T cells.
Transgenic PD-L2 affects transition to memory when expressed on antigen (Ag)-presenting cells at the beginning of interaction with T cells; notably, interaction with PD-1 on T cells is required during the initial encounter with Ag.
Title: APCs expressing high levels of programmed death ligand 2 sustain the development of CD4 T cell memory.

Submit: New GeneRIF Correction See all (33)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description
NP_079515.1	NP_005009.1	PDCD1		BIND	PubMed	PD-1 interacts with B7-DC.
BioGRID:123259	BioGRID:111160	PDCD1		BioGRID	PubMed	Reconstituted Complex

Function	Evidence Code	Pubs
molecular_function	ND No biological Data available more info
protein tyrosine phosphatase activity	TAS Traceable Author Statement more info
receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
T cell costimulation	TAS Traceable Author Statement more info
immune response	NAS Non-traceable Author Statement more info	PubMed
negative regulation of T cell proliferation	IEA Inferred from Electronic Annotation more info
peptidyl-tyrosine dephosphorylation	TAS Traceable Author Statement more info
positive regulation of T cell proliferation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
endomembrane system	IEA Inferred from Electronic Annotation more info
extracellular region	IEA Inferred from Electronic Annotation more info
integral to membrane	IEA Inferred from Electronic Annotation more info
plasma membrane	TAS Traceable Author Statement more info

General protein information

Preferred Names: programmed cell death 1 ligand 2

Names: programmed cell death 1 ligand 2; B7-DC; PD-1 ligand 2; PD-1-ligand 2; PDCD1 ligand 2; butyrophilin B7-DC; programmed death ligand 2; B7 dendritic cell molecule

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_025239.3 → NP_079515.2 programmed cell death 1 ligand 2 precursor

Status: VALIDATED

Source sequence(s)

AF329193, AF344424, AK001872, BX951459, CA442083

Consensus CDS

CCDS6465.1

UniProtKB/Swiss-Prot

Q9BQ51

Related

ENSP00000380855, OTTHUMP00000021030, ENST00000397747, OTTHUMT00000051634

Conserved Domains (1) summary

cl11960
Location:137 – 193
Blast Score: 94

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000009.11 Reference GRCh37.p5 Primary Assembly

Range

5510545..5571282

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000141.1 Alternate HuRef

Range

5466254..5526976

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AL162253.17	CAI15984.1
genomic	CH471071.2	EAW58762.1
mRNA	AF329193.1	AAK31105.1
mRNA	AF344424.1	AAK15370.1
mRNA	AK001872.1	None
mRNA	AY254343.1	AAP13471.1
mRNA	AY271901.1	AAP49000.1
mRNA	AY271902.1	AAP49001.1
mRNA	BC074766.2	AAH74766.1
mRNA	BC113678.1	AAI13679.1
mRNA	BC113680.1	AAI13681.1
mRNA	BC143920.1	None
mRNA	BC143921.1	None
mRNA	BX951459.1	None
mRNA	CA442083.1	None
mRNA	DQ336699.1	ABC59616.1
mRNA	EF444806.1	ABO33153.1
other-genetic	HQ258142.1	ADR82896.1