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    WDR61 WD repeat domain 61 [ Homo sapiens ]

    Gene ID: 80349, updated on 11-May-2012

    Summary

    Official Symbol
    WDR61provided by HGNC
    Official Full Name
    WD repeat domain 61provided by HGNC
    Primary source
    HGNC:30300
    See related
    Ensembl:ENSG00000140395; HPRD:15236; MIM:609540; Vega:OTTHUMG00000143735
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SKI8; REC14
    Summary
    WDR61 is a subunit of the human PAF and SKI complexes, which function in transcriptional regulation and are involved in events downstream of RNA synthesis, such as RNA surveillance (Zhu et al., 2005 [PubMed 16024656]).[supplied by OMIM, Mar 2008]

    Genomic context

    Location :
    15q25.1
    Sequence :
    Chromosome: 15; NC_000015.9 (78575577..78591940, complement)
    See WDR61 in Epigenomics, MapViewer

    Chromosome 15 - NC_000015.9Genomic Context describing neighboring genes Neighboring gene acyl-CoA synthetase bubblegum family member 1 Neighboring gene DnaJ (Hsp40) homolog, subfamily A, member 4 Neighboring gene cellular retinoic acid binding protein 1 Neighboring gene RWD domain containing 1 pseudogene 1

    Genomic regions, transcripts, and products

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q9GZS3 Q04771 ACVR1    HPRD  PubMed  
    Q9GZS3 Q15910 EZH2    HPRD  PubMed  
    Q9GZS3 Q9HCE7 SMURF1    HPRD  PubMed  
    Q9GZS3 P36897 TGFBR1    HPRD  PubMed  
    BioGRID:123255 BioGRID:122724 CDC73    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123255 BioGRID:115004 CTR9    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:123255 BioGRID:114029 CUL4A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:123255 BioGRID:114028 CUL4B    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:123255 BioGRID:108446 EZH2    BioGRID  PubMed Two-hybrid 
    BioGRID:123255 BioGRID:125817 LEO1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123255 BioGRID:110438 MLH1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123255 BioGRID:110443 MLL    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:123255 BioGRID:120081 PAF1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:123255 BioGRID:116780 RTF1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:123255 BioGRID:212207 Sf3a1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123255 BioGRID:112779 TCEA1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:123255 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123255 BioGRID:31215 UBI4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:123255 BioGRID:116272 WDR5    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:123255 BioGRID:116168 YWHAQ    BioGRID  PubMed Affinity Capture-MS 

    General gene information

    Markers

    Homology

    • Homologs of the WDR61 gene: The WDR61 gene is conserved in chimpanzee, , dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, S.pombe, , N.crassa, A.thaliana, and rice.
    • Map Viewer (Mouse, Rat)

    Pathways from BioSystems

    • RNA degradation, organism-specific biosystem (from KEGG)
      RNA degradation, organism-specific biosystemThe correct processing, quality control and turnover of cellular RNA molecules are critical to many aspects in the expression of genetic information. In eukaryotes, two major pathways of mRNA decay e...
    • RNA degradation, conserved biosystem (from KEGG)
      RNA degradation, conserved biosystemThe correct processing, quality control and turnover of cellular RNA molecules are critical to many aspects in the expression of genetic information. In eukaryotes, two major pathways of mRNA decay e...
    • Ski complex, organism-specific biosystem (from KEGG)
      Ski complex, organism-specific biosystemStructural complex; Genetic information processing; RNA processing
    • Ski complex, conserved biosystem (from KEGG)
      Ski complex, conserved biosystemStructural complex; Genetic information processing; RNA processing

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
     
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    WD repeat-containing protein 61
    Names
    WD repeat-containing protein 61
    recombination protein REC14
    meiotic recombination REC14 protein homolog

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025234.1NP_079510.1  WD repeat-containing protein 61

      Status: PROVISIONAL

      Source sequence(s)
      AK024754
      Consensus CDS
      CCDS10300.1
      UniProtKB/Swiss-Prot
      Q9GZS3
      Related
      ENSP00000267973, OTTHUMP00000184910, ENST00000267973, OTTHUMT00000289803
      Conserved Domains (1) summary
      cd00200
      Location:13302
      Blast Score: 460
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000015.9 Reference GRCh37.p5 Primary Assembly

      Range
      78575577..78591940, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000147.1 Alternate HuRef

      Range
      55333673..55350040, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC090607.6 (99621..115984) None
    genomic CH471136.2 EAW99173.1
      EAW99174.1
      EAW99175.1
    mRNA AF100786.1 AAP97225.1
    mRNA AF127799.1 AAP97249.1
    mRNA AF309553.1 AAG31639.1
    mRNA AK024754.1 BAB14986.1
    mRNA AK300838.1 BAG62489.1
    mRNA AK304617.1 BAG65399.1
    mRNA AK311320.1 None
    mRNA BC010080.2 AAH10080.1
    mRNA CR457333.1 CAG33614.1
    other-genetic HQ447187.1 ADQ31674.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9GZS3.1 GenPept UniProtKB/Swiss-Prot:Q9GZS3

      Supplemental Content

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