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SLC25A16 solute carrier family 25 member 16 [ Homo sapiens (human) ]

Gene ID: 8034, updated on 8-May-2016
Official Symbol
SLC25A16provided by HGNC
Official Full Name
solute carrier family 25 member 16provided by HGNC
Primary source
HGNC:HGNC:10986
See related
Ensembl:ENSG00000122912 HPRD:00740; MIM:139080
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GDA; GDC; ML7; hML7; HGT.1; D10S105E
Summary
This gene encodes a protein that contains three tandemly repeated mitochondrial carrier protein domains. The encoded protein is localized in the inner membrane and facilitates the rapid transport and exchange of molecules between the cytosol and the mitochondrial matrix space. This gene has a possible role in Graves' disease. [provided by RefSeq, Jul 2008]
Orthologs
Location:
10q21.3
Exon count:
13
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 10 NC_000010.11 (68473387..68527523, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (70242090..70287280, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L26 pseudogene 29 Neighboring gene DNA replication helicase/nuclease 2 Neighboring gene RNA, 5S ribosomal pseudogene 319 Neighboring gene ribosomal protein L26 pseudogene 27 Neighboring gene transmembrane protein 14D, pseudogene Neighboring gene tet methylcytosine dioxygenase 1 Neighboring gene COX20 cytochrome c oxidase assembly factor pseudogene 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Coenzyme A biosynthesis, organism-specific biosystem (from REACTOME)
    Coenzyme A biosynthesis, organism-specific biosystemCoenzyme A (CoA) is a ubiquitous cofactor that functions as an acyl group carrier in diverse processes including fatty acid metabolism and the TCA cycle (Lipmann 1953). It is synthesized from the vit...
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of vitamins and cofactors, organism-specific biosystem (from REACTOME)
    Metabolism of vitamins and cofactors, organism-specific biosystemVitamins are a diverse group of organic compounds, classified according to their solubility, either fat-soluble or water-soluble, that are either not synthesized or synthesized only in limited amount...
  • Metabolism of water-soluble vitamins and cofactors, organism-specific biosystem (from REACTOME)
    Metabolism of water-soluble vitamins and cofactors, organism-specific biosystemVitamins are a diverse group of organic compounds, required in small amounts in the diet. They have distinct biochemical roles, often as coenzymes, and are either not synthesized or synthesized only ...
  • Vitamin B5 (pantothenate) metabolism, organism-specific biosystem (from REACTOME)
    Vitamin B5 (pantothenate) metabolism, organism-specific biosystemPanthothenate (vitamin B5) is the precursor of coenzyme A (Robishaw and Neely 1985) and is the prosthetic group of acyl carrier protein (ACP) (Joshi et al. 2003). Its name is derived from the Greek p...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC39851

Gene Ontology Provided by GOA

Function Evidence Code Pubs
antiporter activity NAS
Non-traceable Author Statement
more info
PubMed 
secondary active transmembrane transporter activity TAS
Traceable Author Statement
more info
 
structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
coenzyme biosynthetic process TAS
Traceable Author Statement
more info
 
translation IBA
Inferred from Biological aspect of Ancestor
more info
 
transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
transport NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
Preferred Names
graves disease carrier protein
Names
mitochondrial solute carrier protein homolog
solute carrier family 25 (mitochondrial carrier; Graves disease autoantigen), member 16

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046972.1 RefSeqGene

    Range
    5001..50191
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001324312.1NP_001311241.1  graves disease carrier protein isoform b

    Status: REVIEWED

    Source sequence(s)
    AK295287, AL136233, AL713888
  2. NM_001324313.1NP_001311242.1  graves disease carrier protein isoform c

    Status: REVIEWED

    Source sequence(s)
    AL713888
  3. NM_001324314.1NP_001311243.1  graves disease carrier protein isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) and variant 5 both encode the same isoform (d).
    Source sequence(s)
    AL136233, AL713888
  4. NM_001324315.1NP_001311244.1  graves disease carrier protein isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) and variant 4 both encode the same isoform (d).
    Source sequence(s)
    AL136233, AL713888
  5. NM_001324317.1NP_001311246.1  graves disease carrier protein isoform e

    Status: REVIEWED

    Source sequence(s)
    AL136233, AL713888
  6. NM_152707.3NP_689920.1  graves disease carrier protein isoform a

    See identical proteins and their annotated locations for NP_689920.1

    Status: REVIEWED

    Source sequence(s)
    AK290255, AL136233, AL713888, BU684567, DA023888
    Consensus CDS
    CCDS7280.1
    UniProtKB/Swiss-Prot
    P16260
    Related
    ENSP00000476815, OTTHUMP00000019707, ENST00000609923, OTTHUMT00000048347
    Conserved Domains (2) summary
    PTZ00169
    Location:36330
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    pfam00153
    Location:33125
    Mito_carr; Mitochondrial carrier protein

RNA

  1. NR_136737.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL136233, AL713888

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p2 Primary Assembly

    Range
    68473387..68527523 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011540212.1XP_011538514.1  

    See identical proteins and their annotated locations for XP_011538514.1

    UniProtKB/Swiss-Prot
    P16260
    Conserved Domains (2) summary
    PTZ00169
    Location:36330
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    pfam00153
    Location:33125
    Mito_carr; Mitochondrial carrier protein
  2. XM_011540211.1XP_011538513.1  

    See identical proteins and their annotated locations for XP_011538513.1

    UniProtKB/Swiss-Prot
    P16260
    Conserved Domains (2) summary
    PTZ00169
    Location:36330
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    pfam00153
    Location:33125
    Mito_carr; Mitochondrial carrier protein
  3. XM_006717987.2XP_006718050.1  

    UniProtKB/TrEMBL
    B4DPV4
    Conserved Domains (1) summary
    pfam00153
    Location:33116
    Mito_carr; Mitochondrial carrier protein
  4. XM_005270183.3XP_005270240.1  

    Conserved Domains (1) summary
    pfam00153
    Location:97189
    Mito_carr; Mitochondrial carrier protein

Alternate CHM1_1.1

Genomic

  1. NC_018921.2 Alternate CHM1_1.1

    Range
    70524338..70569332 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)