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PDGFD platelet derived growth factor D [ Homo sapiens (human) ]

Gene ID: 80310, updated on 7-May-2016
Official Symbol
PDGFDprovided by HGNC
Official Full Name
platelet derived growth factor Dprovided by HGNC
Primary source
HGNC:HGNC:30620
See related
Ensembl:ENSG00000170962 HPRD:17830; MIM:609673; Vega:OTTHUMG00000165953
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IEGF; SCDGFB; MSTP036; SCDGF-B
Summary
The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines, seven of which are found in this factor. This gene product only forms homodimers and, therefore, does not dimerize with the other three family members. It differs from alpha and beta members of this family in having an unusual N-terminal domain, the CUB domain. Two splice variants have been identified for this gene. [provided by RefSeq, Jul 2008]
Orthologs
Location:
11q22.3
Exon count:
7
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 11 NC_000011.10 (103907186..104164299, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (103777914..104035027, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369464 Neighboring gene microRNA 4693 Neighboring gene uncharacterized LOC105369465 Neighboring gene DNA damage inducible 1 homolog 1 Neighboring gene uncharacterized LOC102723879 Neighboring gene RNA, 5S ribosomal pseudogene 348 Neighboring gene microRNA 7641-1 Neighboring gene uncharacterized LOC102723895

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease.
NHGRI GWA Catalog
Duffy-null-associated low neutrophil counts influence HIV-1 susceptibility in high-risk South African black women.
NHGRI GWA Catalog
Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.
NHGRI GWA Catalog
Genome-wide association study of selenium concentrations.
NHGRI GWA Catalog
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  • Phospholipase D signaling pathway, organism-specific biosystem (from KEGG)
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  • Phospholipase D signaling pathway, conserved biosystem (from KEGG)
    Phospholipase D signaling pathway, conserved biosystemPhospholipase D (PLD) is an essential enzyme responsible for the production of the lipid second messenger phosphatidic acid (PA), which is involved in fundamental cellular processes, including membra...
  • Prostate cancer, organism-specific biosystem (from KEGG)
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    Regulation of actin cytoskeleton, organism-specific biosystem
    Regulation of actin cytoskeleton
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    Regulation of actin cytoskeleton
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Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC26867

Gene Ontology Provided by GOA

Function Evidence Code Pubs
growth factor activity IEA
Inferred from Electronic Annotation
more info
 
platelet-derived growth factor receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
blood coagulation IBA
Inferred from Biological aspect of Ancestor
more info
 
cellular response to amino acid stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to hydrogen peroxide IEA
Inferred from Electronic Annotation
more info
 
cellular response to platelet-derived growth factor stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to transforming growth factor beta stimulus IEA
Inferred from Electronic Annotation
more info
 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
platelet-derived growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
positive regulation of ERK1 and ERK2 cascade IBA
Inferred from Biological aspect of Ancestor
more info
 
positive regulation of MAP kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
positive regulation of cell division IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
 
positive regulation of cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
 
positive regulation of fibroblast proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of glomerular mesangial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of monocyte extravasation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of phosphatidylinositol 3-kinase signaling IBA
Inferred from Biological aspect of Ancestor
more info
 
positive regulation of protein autophosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
positive regulation of smooth muscle cell chemotaxis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of smooth muscle cell proliferation IEA
Inferred from Electronic Annotation
more info
 
regulation of peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi membrane TAS
Traceable Author Statement
more info
 
endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
Preferred Names
platelet-derived growth factor D
Names
PDGF-D
iris-expressed growth factor
spinal cord derived growth factor B
spinal cord-derived growth factor B
spinal cord-derived growth factor-B

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025208.4NP_079484.1  platelet-derived growth factor D isoform 1 precursor

    See identical proteins and their annotated locations for NP_079484.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AF113216, AI962915, BC030645
    Consensus CDS
    CCDS41703.1
    UniProtKB/Swiss-Prot
    Q9GZP0
    Related
    ENSP00000376865, OTTHUMP00000231596, ENST00000393158, OTTHUMT00000387231
    Conserved Domains (2) summary
    cd00041
    Location:55168
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00135
    Location:270365
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and ...
  2. NM_033135.3NP_149126.1  platelet-derived growth factor D isoform 2 precursor

    See identical proteins and their annotated locations for NP_149126.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AF113216, AI962915, BC030645
    Consensus CDS
    CCDS8326.1
    UniProtKB/Swiss-Prot
    Q9GZP0
    Related
    ENSP00000302193, OTTHUMP00000231641, ENST00000302251, OTTHUMT00000387322
    Conserved Domains (2) summary
    cd00041
    Location:49162
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00135
    Location:264359
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p2 Primary Assembly

    Range
    103907186..104164299 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018922.2 Alternate CHM1_1.1

    Range
    103660854..103917997 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)