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    CDK5RAP3 CDK5 regulatory subunit associated protein 3 [ Homo sapiens ]

    Gene ID: 80279, updated on 11-May-2012
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    Summary

    Official Symbol
    CDK5RAP3provided by HGNC
    Official Full Name
    CDK5 regulatory subunit associated protein 3provided by HGNC
    Primary source
    HGNC:18673
    Locus tag
    MSTP016
    See related
    Ensembl:ENSG00000108465; HPRD:12190; MIM:608202
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C53; IC53; LZAP; HSF-27; MST016; OK/SW-cl.114
    Summary
    Neuronal CDC2-like kinase, which is involved in the regulation of neuronal differentiation, is composed of a catalytic subunit, CDK5, and an activating subunit, p25NCK5A. The protein encoded by this gene binds to p25NCK5A and therefore may be involved in neuronal differentiation. The encoded protein, which may be a substrate of neuronal CDC2-like kinase, has also been found in vascular endothelial cells, where it mediates cell proliferation. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    17q21.32
    Sequence :
    Chromosome: 17; NC_000017.10 (46048429..46059147)
    See CDK5RAP3 in Epigenomics, MapViewer

    Chromosome 17 - NC_000017.10Genomic Context describing neighboring genes Neighboring gene pyridoxamine 5'-phosphate oxidase Neighboring gene proline rich 15-like Neighboring gene coatomer protein complex, subunit zeta 2 Neighboring gene microRNA 152 Neighboring gene nuclear factor (erythroid-derived 2)-like 1

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Identification of LZAP as a new candidate tumor suppressor in hepatocellular carcinoma. Zhao JJ, et al. PLoS One, 2011. PMID 22028922.
    2. Interaction of LHBs with C53 promotes hepatocyte mitotic entry: A novel mechanism for HBV-induced hepatocellular carcinoma. Lei Y, et al. Oncol Rep, 2012 Jan. PMID 21971960.
    3. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    4. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    5. Nuclear γ-tubulin associates with nucleoli and interacts with tumor suppressor protein C53. Hořejší B, et al. J Cell Physiol, 2012 Jan. PMID 21465471.

    See all (37) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. LZAP may play an important role in hepatocellular carcinoma progression
      Title: Identification of LZAP as a new candidate tumor suppressor in hepatocellular carcinoma.
    2. our results strongly suggest that the binding of hepatitis viral pre-S2 LHBs with C53 is a novel negative regulator of the checkpoint response
      Title: Interaction of LHBs with C53 promotes hepatocyte mitotic entry: A novel mechanism for HBV-induced hepatocellular carcinoma.
    3. Data indicate that IC53 is a positive mediator for colon cancer progression, and IC53-rs2737 may serve as protection from the onset of colorectal cancer.
      Title: A functional variant of IC53 correlates with the late onset of colorectal cancer.
    4. Nuclear gamma-tubulin interacts with tumor suppressor protein C53 that is involved in regulation of DNA damage
      Title: Nuclear γ-tubulin associates with nucleoli and interacts with tumor suppressor protein C53.
    5. the ability of LZAP to alter p38 phosphorylation depended, at least partially, on the p38 phosphatase, Wip1
      Title: LZAP inhibits p38 MAPK (p38) phosphorylation and activity by facilitating p38 association with the wild-type p53 induced phosphatase 1 (WIP1).
    6. Findings reveal that CDK5RAP3 is widely overexpressed in hepatocellular carcinoma and that overexpression of CDK5RAP3 promotes HCC metastasis through PAK4 activation.
      Title: Overexpression of a novel activator of PAK4, the CDK5 kinase-associated protein CDK5RAP3, promotes hepatocellular carcinoma metastasis.
    7. found that C53/LZAP and DDRGK1 became more susceptible to the proteasome-mediated degradation in RCAD knockdown cells, whereas their ubiquitination was significantly attenuated by RCAD overexpression
      Title: A novel C53/LZAP-interacting protein regulates stability of C53/LZAP and DDRGK domain-containing Protein 1 (DDRGK1) and modulates NF-kappaB signaling.
    8. Endothelium-specific overexpression of human IC53 downregulates endothelial nitric oxide synthase activity and elevates systolic blood pressure in mice.
      Title: Endothelium-specific overexpression of human IC53 downregulates endothelial nitric oxide synthase activity and elevates systolic blood pressure in mice.
    9. CDK5 regulatory subunit associated protein 3 promotes checkpoint kinase 1 activation and mitotic entry in both unperturbed cell-cycle progression and DNA damage response.
      Title: Tumor suppressor protein C53 antagonizes checkpoint kinases to promote cyclin-dependent kinase 1 activation.
    10. it is concluded that CDK5RAP3, CCNB2, and RAGE genes may be used as a very reliable biomarkers of lung adenocarcinoma
      Title: Usefulness of CDK5RAP3, CCNB2, and RAGE genes for the diagnosis of lung adenocarcinoma.
    Submit: New GeneRIF Correction See all (15)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q96JB5 Q15078 CDK5R1    HPRD  PubMed  
    Q96JB5 Q92793 CREBBP    HPRD  PubMed  
    Q96JB5 Q14194 CRMP1    HPRD  PubMed  
    Q96JB5 Q9Y5M8 SRPRB    HPRD  PubMed  
    BioGRID:123213 BioGRID:106893 ARL1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123213 BioGRID:107437 CDH4    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-fractionation 
    BioGRID:123213 BioGRID:114376 CDK5R1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:123213 BioGRID:159447 CDK5R1    BioGRID  PubMed Two-hybrid 
    BioGRID:123213 BioGRID:107790 CRMP1    BioGRID  PubMed Two-hybrid 
    BioGRID:123213 BioGRID:122441 DDRGK1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:123213 BioGRID:118061 DISC1    BioGRID  PubMed Two-hybrid 
    BioGRID:123213 BioGRID:109540 HSPA4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123213 BioGRID:109544 HSPA8    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123213 BioGRID:115385 HUWE1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123213 BioGRID:109714 IGHA1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123213 BioGRID:109734 IGKC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123213 BioGRID:109996 KHK    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123213 BioGRID:126243 LYPD6B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123213 BioGRID:110455 MME    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123213 BioGRID:110929 NPM1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123213 BioGRID:110813 RPL10A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123213 BioGRID:112102 RPS3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123213 BioGRID:115574 SMNDC1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123213 BioGRID:120700 TMEM55A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123213 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:123213 BioGRID:119577 UFC1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123213 BioGRID:116953 UFL1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:123213 BioGRID:119616 UFM1    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    neuronal Cdc2-like kinase binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    brain development NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    regulation of cyclin-dependent protein kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    regulation of neuron differentiation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    cellular_component ND
    No biological Data available
    more info
    		  
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    General protein information

    Preferred Names
    CDK5 regulatory subunit-associated protein 3
    Names
    CDK5 regulatory subunit-associated protein 3
    ischemic heart CDK5 activator-binding protein C53
    LXXLL/leucine-zipper-containing ARFbinding protein
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_176096.1 → NP_788276.1  CDK5 regulatory subunit-associated protein 3

      Status: REVIEWED

      Source sequence(s)
      AK000260, AK023722, BM908175
      Consensus CDS
      CCDS42356.1
      UniProtKB/Swiss-Prot
      Q96JB5
      Related
      ENSP00000344683, ENST00000338399
      Conserved Domains (1) summary
      pfam05600
      Location:1 – 503
      Blast Score: 1803
      DUF773; Protein of unknown function (DUF773)

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000017.10 Reference GRCh37.p5 Primary Assembly

      Range
      46048429..46059147
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000149.1 Alternate HuRef

      Range
      41417132..41427848
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_025197.2: Suppressed sequence

      Description
      NM_025197.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.

    2. NM_176095.1: Suppressed sequence

      Description
      NM_176095.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC018521.8 (15437..26155) None
    genomic CH471109.2 EAW94772.1
      EAW94773.1
      EAW94774.1
      EAW94775.1
      EAW94776.1
      EAW94777.1
      EAW94778.1
    mRNA AB062433.1 BAB93496.1
    mRNA AF110322.1 AAG39277.1
    mRNA AF217982.2 AAG17225.1
    mRNA AF343090.1 AAK69655.1
    mRNA AK000260.1 None
    mRNA AK023722.1 BAB14657.1
    mRNA AK223387.1 BAD97107.1
    mRNA AK225274.1 None
    mRNA AK300643.1 BAH13320.1
    mRNA AK301739.1 BAG63203.1
    mRNA BC009957.2 AAH09957.1
    mRNA BC013407.2 None
    mRNA BC072435.1 AAH72435.1
    mRNA BM908175.1 None
    other-genetic HQ448144.1 ADQ32625.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96JB5.2 GenPept UniProtKB/Swiss-Prot:Q96JB5
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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