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    STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 [ Homo sapiens ]

    Gene ID: 8027, updated on 12-May-2012
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    Summary

    Official Symbol
    STAMprovided by HGNC
    Official Full Name
    signal transducing adaptor molecule (SH3 domain and ITAM motif) 1provided by HGNC
    Primary source
    HGNC:11357
    See related
    Ensembl:ENSG00000136738; HPRD:03542; MIM:601899; Vega:OTTHUMG00000017749
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    STAM1; STAM-1; DKFZp686J2352
    Summary
    This gene encodes a member of the signal-transducing adaptor molecule family. These proteins mediate downstream signaling of cytokine receptors and also play a role in ER to Golgi trafficking by interacting with the coat protein II complex. The encoded protein also associates with hepatocyte growth factor-regulated substrate to form the endosomal sorting complex required for transport-0 (ESCRT-0), which sorts ubiquitinated membrane proteins to the ESCRT-1 complex for lysosomal degradation. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Feb 2011]
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    Genomic context

    Location :
    10p14-p13
    Sequence :
    Chromosome: 10; NC_000010.10 (17686124..17758823)
    See STAM in Epigenomics, MapViewer

    Chromosome 10 - NC_000010.10Genomic Context describing neighboring genes Neighboring gene PRP38 pre-mRNA processing factor 38 (yeast) domain containing A pseudogene Neighboring gene protein tyrosine phosphatase-like (proline instead of catalytic arginine), member A Neighboring gene transmembrane protein 236 Neighboring gene microRNA 511-1

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. Lee KA, et al. J Biol Chem, 2011 Dec 2. PMID 21987572.
    2. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    3. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    4. Solution structure of UIM and interaction of tandem ubiquitin binding domains in STAM1 with ubiquitin. Lim J, et al. Biochem Biophys Res Commun, 2011 Feb 4. PMID 21187078.
    5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048.

    See all (48) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Observational study of gene-disease association. (HuGE Navigator)
      Title: A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
    2. A novel ubiquitin binding site and the manner of ubiquitin recognition of the STAM1 VHS domain were proposed.
      Title: Identification of a novel ubiquitin binding site of STAM1 VHS domain by NMR spectroscopy.
    3. STAMs function prominently in endoplasmic reticulum-to-Golgi trafficking, most likely through direct interactions with the coat protein II complex
      Title: STAM adaptor proteins interact with COPII complexes and function in ER-to-Golgi trafficking.
    4. The cellular functions of UBPY are complex but clearly distinct from those of the Lys-63-ubiquitin-specific protease, AMSH, with which it shares a binding site on the SH3 domain of STAM
      Title: The ubiquitin isopeptidase UBPY regulates endosomal ubiquitin dynamics and is essential for receptor down-regulation.
    5. Analysis with phospho-specific antibodies indicates that 3 kinases generate a signal-specific, combinatorial phosphorylation profile of the Hrs-STAM complex, with the potential of diversifying tyrosine kinase receptor signalling through a common element.
      Title: Growth factors induce differential phosphorylation profiles of the Hrs-STAM complex: a common node in signalling networks with signal-specific properties.
    6. Interaction of TIMM8a with STAM1.
      Title: Interaction of the deafness-dystonia protein DDP/TIMM8a with the signal transduction adaptor molecule STAM1.
    7. Hrs is a master molecule that controls in part the degradation of STAM1 and the accumulation of ubiquitinated proteins
      Title: Hrs, a mammalian master molecule in vesicular transport and protein sorting, suppresses the degradation of ESCRT proteins signal transducing adaptor molecule 1 and 2.
    8. Data suggested that association with hepatocyte growth factor-regulated tyrosine kinase substrate is a prerequisite for STAM1 function in early endosome.
      Title: Association with Hrs is required for the early endosomal localization, stability, and function of STAM.
    9. STAM proteins function in a multivalent complex that sorts ubiquitinated proteins into the multivesicular body pathway.
      Title: STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q92783 O14964 HGS    HPRD  PubMed  
    Q92783 P23458 JAK1    HPRD  PubMed  
    Q92783 O60674 JAK2    HPRD  PubMed  
    Q92783 P52333 JAK3    HPRD  PubMed  
    Q92783 P62136 PPP1CA    HPRD  PubMed  
    Q92783 O95630 STAMBP    HPRD  PubMed  
    Q92783 O60220 TIMM8A    HPRD  PubMed  
    Q92783 P40818 USP8    HPRD  PubMed  
    BioGRID:113722 BioGRID:106900 ARR3    BioGRID  PubMed Co-localization 
    BioGRID:113722 BioGRID:106901 ARRB1    BioGRID  PubMed Affinity Capture-Western; Co-localization; Reconstituted Complex 
    BioGRID:113722 BioGRID:107412 CD79B    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113722 BioGRID:107623 CLTC    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113722 BioGRID:113607 CXCR4    BioGRID  PubMed Co-localization 
    BioGRID:113722 BioGRID:109285 HARS    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113722 BioGRID:114593 HGS    BioGRID  PubMed Affinity Capture-Western; Co-fractionation; Reconstituted Complex; Two-hybrid 
    BioGRID:113722 BioGRID:109920 JAK2    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:113722 BioGRID:109921 JAK3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113722 BioGRID:115863 STAMBP    BioGRID  PubMed Affinity Capture-Western; Co-localization; Protein-peptide; Reconstituted Complex 
    BioGRID:113722 BioGRID:108042 TIMM8A    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:113722 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113722 BioGRID:31215 UBI4    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113722 BioGRID:114555 USP8    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; PCA; Reconstituted Complex 
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    General gene information

    Markers

    Genotypes

    Homology

    • Homologs of the STAM gene: The STAM gene is conserved in chimpanzee, , dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, , S.pombe, , and N.crassa.
    • Map Viewer (Mouse, Rat)

    Pathways from BioSystems

    • Disease, organism-specific biosystem (from REACTOME)
      Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
    • EGFR downregulation, organism-specific biosystem (from REACTOME)
      EGFR downregulation, organism-specific biosystemRegulation of receptor tyrosine kinase (RTK) activity is implicated in the control of almost all cellular functions. One of the best understood RTKs is epidermal growth factor receptor (EGFR). Growth...
    • ESCRT-0 complex, organism-specific biosystem (from KEGG)
      ESCRT-0 complex, organism-specific biosystemStructural complex; Genetic information processing; Protein processing
    • Endocytosis, organism-specific biosystem (from KEGG)
      Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Endocytosis, conserved biosystem (from KEGG)
      Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Endosomal Sorting Complex Required For Transport (ESCRT), organism-specific biosystem (from REACTOME)
      Endosomal Sorting Complex Required For Transport (ESCRT), organism-specific biosystemMany plasma membrane proteins are in a constant flux throughout the internal trafficking pathways of the cell. Some receptors are continuously internalized into recycling endosomes and returned to th...
    • IL-2 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-2 Signaling Pathway, organism-specific biosystemInterleukin-2 belongs to a family of cytokines, which includes IL-4, IL-7, IL-9, IL-15 and IL-21. IL-2 signals through a receptor complex consisting of IL-2 specific IL-2 receptor alpha (CD25), IL-2 ...
    • IL-4 signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-4 signaling Pathway, organism-specific biosystemInterleukin-4 belongs to the IL-2 family of cytokines, which includes IL-2, IL-7, IL-9, IL-15 and IL-21. It signals through 2 different receptor complexes; Receptor complex 1 comprises of IL-4 recept...
    • IL-7 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-7 Signaling Pathway, organism-specific biosystemInterleukin-7 belongs to a family of cytokines, which includes IL-2, IL-4, IL-9, IL-15 and IL-21. It signals through a receptor complex consisting of IL-7 receptor alpha chain (IL7RA) and a common ga...
    • IL2-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
      IL2-mediated signaling events, organism-specific biosystem
      IL2-mediated signaling events
    • Jak-STAT signaling pathway, organism-specific biosystem (from KEGG)
      Jak-STAT signaling pathway, organism-specific biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
    • Jak-STAT signaling pathway, conserved biosystem (from KEGG)
      Jak-STAT signaling pathway, conserved biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
    • Membrane Trafficking, organism-specific biosystem (from REACTOME)
      Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by EGFR, organism-specific biosystem (from REACTOME)
      Signaling by EGFR, organism-specific biosystemThe epidermal growth factor receptor (EGFR) is one member of the ERBB family of transmembrane glycoprotein tyrosine receptor kinases (RTK). Binding of EGFR to its ligands induces conformational chang...
    • Signaling by EGFR in Cancer, organism-specific biosystem (from REACTOME)
      Signaling by EGFR in Cancer, organism-specific biosystemThe pathway "Signaling by EGFR in Cancer" shows "Signaling by constitutively active EGFR" in parallel with "Signaling by EGFR". This allows users to compare signaling by constitutively active EGFR ca...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    SH3/SH2 adaptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    cellular membrane organization TAS
    Traceable Author Statement
    more info
    		  
    endosome transport TAS
    Traceable Author Statement
    more info
    		  
    epidermal growth factor receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of epidermal growth factor receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytosol TAS
    Traceable Author Statement
    more info
    		  
    early endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    signal transducing adapter molecule 1
    Names
    signal transducing adapter molecule 1
    HSE1 homolog
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003473.3 → NP_003464.1  signal transducing adapter molecule 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes a functional protein.
      Source sequence(s)
      AC069542, AU118708, U43899
      Consensus CDS
      CCDS7122.1
      UniProtKB/Swiss-Prot
      Q92783
      Related
      ENSP00000366746, OTTHUMP00000019237, ENST00000377524, OTTHUMT00000047039
      Conserved Domains (2) summary
      cd00174
      Location:214 – 265
      Blast Score: 200
      SH3; Src homology 3 domains; SH3 domains bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs; they play a role in the regulation of enzymes by intramolecular interactions, changing the subcellular localization of ...
      cd03568
      Location:9 – 142
      Blast Score: 538
      VHS_STAM; VHS domain family, STAM subfamily; members include STAM (Signal Transducing Adaptor Molecule), EAST (EGFR-associated protein with SH3 and TAM domains) and Hbp (Hrs-binding protein). Collectively, they are referred to as STAM. All STAMs have at their ...

    RNA

    1. NR_037774.1 RNA Sequence

      Description
      Transcript Variant: This variant (2) lacks two alternate internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC069542, AK303083, AU118708, U43899

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000010.10 Reference GRCh37.p5 Primary Assembly

      Range
      17686124..17758823
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p5 PATCHES

    Genomic

    1. NW_003315932.1 Reference GRCh37.p5 PATCHES

      Range
      72916..145615
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000142.1 Alternate HuRef

      Range
      17598859..17671557
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC069542.7 (18894..91594) None
    genomic CH471072.2 EAW86207.1
      EAW86208.1
      EAW86209.1
    genomic EF445033.1 ACA06077.1
      ACA06078.1
    genomic GN344117.1 CAY55994.1
    mRNA AK024383.1 None
    mRNA AK303083.1 BAG64194.1
    mRNA AK314405.1 BAG37028.1
    mRNA AU118708.1 None
    mRNA BC030586.2 AAH30586.1
    mRNA BX647982.1 None
    mRNA U43899.1 AAC50734.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q92783.3 GenPept UniProtKB/Swiss-Prot:Q92783
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Miscellaneous

      Supplemental Content

      Table of contents

      Links

      Links to other resources

      General information

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