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RNF34 ring finger protein 34, E3 ubiquitin protein ligase [ Homo sapiens (human) ]

Gene ID: 80196, updated on 19-Jul-2014
Official Symbol
RNF34provided by HGNC
Official Full Name
ring finger protein 34, E3 ubiquitin protein ligaseprovided by HGNC
Primary source
HGNC:17297
See related
Ensembl:ENSG00000170633; HPRD:10509; MIM:608299; Vega:OTTHUMG00000171524
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RFI; RIF; RIFF; hRFI; CARP1; CARP-1
Summary
The protein encoded by this gene contains a RINF finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein interacts with DNAJA3/hTid-1, which is a DnaJ protein reported to function as a modulator of apoptosis. Overexpression of this gene in Hela cells was shown to confer the resistance to TNF-alpha induced apoptosis, suggesting an anti-apoptotic function of this protein. This protein can be cleaved by caspase-3 during the induction of apoptosis. This protein also targets p53 and phospho-p53 for degradation. Alternatively splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2012]
See RNF34 in Epigenomics, MapViewer
Location:
12q24.31
Exon count :
7
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 12 NC_000012.12 (121400083..121424352)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (121837886..121862155)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene calcium/calmodulin-dependent protein kinase kinase 2, beta Neighboring gene anaphase promoting complex subunit 5 Neighboring gene lysine (K)-specific demethylase 2B Neighboring gene microRNA 7107 Neighboring gene uncharacterized LOC101928346

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Adaptive Immune System, organism-specific biosystem (from REACTOME)
    Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
  • Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem (from REACTOME)
    Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystemIntracellular foreign or aberrant host proteins are cleaved into peptide fragments of a precise size, such that they can be loaded on to class I MHC molecules and presented externally to cytotoxic T ...
  • Class I MHC mediated antigen processing & presentation, organism-specific biosystem (from REACTOME)
    Class I MHC mediated antigen processing & presentation, organism-specific biosystemMajor histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular b...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ligase activity IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol phosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
endomembrane system IEA
Inferred from Electronic Annotation
more info
 
nuclear speck IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
E3 ubiquitin-protein ligase RNF34
Names
E3 ubiquitin-protein ligase RNF34
caspase regulator CARP1
RING finger protein RIFF
FYVE-RING finger protein MOMO
caspases-8 and -10-associated RING finger protein 1
human RING finger homologous to inhibitor of apoptosis protein
NP_001243787.1
NP_079402.2
NP_919247.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256858.1NP_001243787.1  E3 ubiquitin-protein ligase RNF34 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has multiple differences in the 5' coding region which results in the use of an alternate translational start codon, compared to variant 1. The resulting isoform (3) has a shorter N-terminus, compared to variant 1.
    Source sequence(s)
    AK025439, BI559962, DB242808
    UniProtKB/Swiss-Prot
    Q969K3
    Conserved Domains (1) summary
    cd00162
    Location:133171
    Blast Score: 80
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably ...
  2. NM_025126.3NP_079402.2  E3 ubiquitin-protein ligase RNF34 isoform 2

    See proteins identical to NP_079402.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 5' coding region which results in the use of an alternate translational start codon, compared to variant 1. The resulting isoform (2) lacks one amino acid in the N-terminus, compared isoform 1.
    Source sequence(s)
    AF306709, AK025439
    Consensus CDS
    CCDS31915.1
    UniProtKB/Swiss-Prot
    Q969K3
    Related
    ENSP00000355137, OTTHUMP00000246294, ENST00000361234, OTTHUMT00000413887
    Conserved Domains (2) summary
    cd00162
    Location:325363
    Blast Score: 77
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably ...
    cl17764
    Location:6190
    Blast Score: 81
    FYVE; FYVE domain; Zinc-binding domain; targets proteins to membrane lipids via interaction with phosphatidylinositol-3-phosphate, PI3P; present in Fab1, YOTB, Vac1, and EEA1;
  3. NM_194271.2NP_919247.1  E3 ubiquitin-protein ligase RNF34 isoform 1

    See proteins identical to NP_919247.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AF306709, AK025439, DA887995
    Consensus CDS
    CCDS9221.1
    UniProtKB/Swiss-Prot
    Q969K3
    Related
    ENSP00000376258, OTTHUMP00000246295, ENST00000392465, OTTHUMT00000413888
    Conserved Domains (2) summary
    cd00162
    Location:326364
    Blast Score: 77
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably ...
    cl17764
    Location:6291
    Blast Score: 81
    FYVE; FYVE domain; Zinc-binding domain; targets proteins to membrane lipids via interaction with phosphatidylinositol-3-phosphate, PI3P; present in Fab1, YOTB, Vac1, and EEA1;

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000012.12 

    Range
    121400083..121424352
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000144.1 

    Range
    118847675..118871945
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018923.2 

    Range
    121806339..121830742
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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