BRD3 bromodomain containing 3 [Homo sapiens] - Gene

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Summary

Official Symbol: BRD3provided by HGNC
Official Full Name: bromodomain containing 3provided by HGNC
Primary source: HGNC:1104
Locus tag: RP11-374P20.3
See related: Ensembl:ENSG00000169925; HPRD:03327; MIM:601541; Vega:OTTHUMG00000021004
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ORFX; RING3L; FLJ23227; FLJ41328; KIAA0043
Summary: This gene was identified based on its homology to the gene encoding the RING3 protein, a serine/threonine kinase. The gene localizes to 9q34, a region which contains several major histocompatibility complex (MHC) genes. The function of the encoded protein is not known. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 9q34

Sequence :: Chromosome: 9; NC_000009.11 (136895427..136933141, complement)

See BRD3 in Epigenomics, MapViewer

Chromosome 9 - NC_000009.11 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The BRDT gene was not expressed in testicular tissue from patients with Sertoli cells only, whereas the other three genes of the BET family retained expression in all the sperm pathologies.
Title: Expression of BET genes in testis of men with different spermatogenic impairments.
the structural basis for GATA1 and Brd3 interaction was described.
Title: Structural basis and specificity of acetylated transcription factor GATA1 recognition by BET family bromodomain protein Brd3.
BRD-NUT fusion proteins contribute to carcinogenesis by associating with chromatin and interfering with epithelial differentiation.
Title: BRD-NUT oncoproteins: a family of closely related nuclear proteins that block epithelial differentiation and maintain the growth of carcinoma cells.
Results report that the double bromodomain proteins Brd2 and Brd3 associate preferentially in vivo with hyperacetylated chromatin along the entire lengths of transcribed genes.
Title: The double bromodomain proteins Brd2 and Brd3 couple histone acetylation to transcription.
Activated lymphocytes induced by mitogens or antigens express various sets of genes, including those involved in the expression of cytokines, surface molecules, and nuclear proteins.
Title: Detection of the genes induced in activated lymphocytes by modified differential display.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
Q15059	Bromodomain containing 7	BRD7	HPRD	PubMed
BioGRID:113715	BioGRID:117036	BRD4	BioGRID	PubMed	Affinity Capture-MS
BioGRID:113715	BioGRID:123565	MAP1LC3B	BioGRID	PubMed	Two-hybrid
BioGRID:113715	BioGRID:1205541	tat	BioGRID	PubMed	Reconstituted Complex

Function	Evidence Code	Pubs
molecular_function	ND No biological Data available more info
protein binding	IPI Inferred from Physical Interaction more info

Process	Evidence Code	Pubs
biological_process	ND No biological Data available more info

Component	Evidence Code	Pubs
nucleus	NAS Non-traceable Author Statement more info

General protein information

Preferred Names: bromodomain-containing protein 3

Names: bromodomain-containing protein 3; RING3-like protein; bromodomain-containing 3

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_007371.3 → NP_031397.1 bromodomain-containing protein 3

Status: REVIEWED

Source sequence(s)

AA766480, AK026880, AK123322, BC010699, BI545861, D26362, DW413353

Consensus CDS

CCDS6980.1

UniProtKB/Swiss-Prot

Q15059

Related

ENSP00000305918, OTTHUMP00000022724, ENST00000303407, OTTHUMT00000055390

Conserved Domains (2) summary

cd05497
Location:34 – 140
Blast Score: 608

Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

cd05498
Location:311 – 412
Blast Score: 538

Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000009.11 Reference GRCh37.p5 Primary Assembly

Range

136895427..136933141, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000141.1 Alternate HuRef

Range

106393244..106416418, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC000391.1	None
genomic	AC002105.1	None
genomic	AC002323.1	None
genomic	AL445931.29	CAI13726.1
		CAI13727.1
		CAP58862.1
		CAP58863.1
genomic	AL591386.19 (2000..8141)	None
genomic	CH471090.1	EAW88113.1
		EAW88114.1
		EAW88115.1
genomic	Z81330.1	None
mRNA	AA766480.1	None
mRNA	AF052138.1	None
mRNA	AK026880.1	None
mRNA	AK123322.1	None
mRNA	AK299519.1	BAG61471.1
mRNA	AW409970.1	None
mRNA	AY513270.1	AAS82952.1
mRNA	BC010699.1	None
mRNA	BC030095.1	None
mRNA	BC032124.2	AAH32124.1
mRNA	BI545861.1	None
mRNA	D26362.1	BAA05393.2
mRNA	DW413353.1	None