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    TTI2 TELO2 interacting protein 2 [ Homo sapiens ]

    Gene ID: 80185, updated on 19-May-2012
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    Summary

    Official Symbol
    TTI2provided by HGNC
    Official Full Name
    TELO2 interacting protein 2provided by HGNC
    Primary source
    HGNC:26262
    See related
    Ensembl:ENSG00000129696; HPRD:13390; MIM:614426; Vega:OTTHUMG00000163956
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C8orf41; FLJ23263
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    Genomic context

    Location :
    8p12
    Sequence :
    Chromosome: 8; NC_000008.10 (33356233..33370703, complement)
    See TTI2 in Epigenomics, MapViewer

    Chromosome 8 - NC_000008.10Genomic Context describing neighboring genes Neighboring gene transfer RNA glutamine 43 (anticodon UUG) pseudogene Neighboring gene fucosyltransferase 10 (alpha (1,3) fucosyltransferase) Neighboring gene RNA binding motif protein 4 pseudogene Neighboring gene thymosin beta 4, X-linked pseudogene Neighboring gene MAK16 homolog (S. cerevisiae) Neighboring gene small nucleolar RNA, C/D box 13

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    2. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048.
    3. A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability. Hurov KE, et al. Genes Dev, 2010 Sep 1. PMID 20810650.
    4. Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes. Takai H, et al. Genes Dev, 2010 Sep 15. PMID 20801936.
    5. Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme. Jeronimo C, et al. Mol Cell, 2007 Jul 20. PMID 17643375.

    See all (9) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. TTI1 and TTI2 protect cells from spontaneous DNA damage, and are required for the establishment of the intra-S and G2/M checkpoint.
      Title: A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:123164 BioGRID:109552 HSP90AA1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123164 BioGRID:109540 HSPA4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123164 BioGRID:120343 PIH1D1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123164 BioGRID:111577 PRKDC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123164 BioGRID:122783 RPAP3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123164 BioGRID:114166 RUVBL1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123164 BioGRID:116067 RUVBL2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123164 BioGRID:115223 TELO2    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:123164 BioGRID:115030 TTI1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123164 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    binding IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    TELO2-interacting protein 2
    Names
    TELO2-interacting protein 2
    Tel2 interacting protein 2 homolog
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001102401.2 → NP_001095871.1  TELO2-interacting protein 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR, compared to variant 1. Variants 1-3 encode the same protein.
      Source sequence(s)
      AC091144, BC066935, DB047280
      Consensus CDS
      CCDS6090.1
      UniProtKB/Swiss-Prot
      Q6NXR4
      Related
      ENSP00000411169, OTTHUMP00000225464, ENST00000431156, OTTHUMT00000376555
      Conserved Domains (1) summary
      pfam10521
      Location:149 – 400
      Blast Score: 492
      DUF2454; Protein of unknown function (DUF2454)

    2. NM_001265581.1 → NP_001252510.1  TELO2-interacting protein 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-3 encode the same protein.
      Source sequence(s)
      AC091144, BX648410, DB047280

    3. NM_025115.3 → NP_079391.2  TELO2-interacting protein 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents the longest transcript. Variants 1-3 encode the same protein.
      Source sequence(s)
      AC091144, AK026916
      Consensus CDS
      CCDS6090.1
      UniProtKB/Swiss-Prot
      Q6NXR4
      Related
      ENSP00000353971, OTTHUMP00000225463, ENST00000360742, OTTHUMT00000376554
      Conserved Domains (1) summary
      pfam10521
      Location:149 – 400
      Blast Score: 492
      DUF2454; Protein of unknown function (DUF2454)

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000008.10 Reference GRCh37.p5 Primary Assembly

      Range
      33356233..33370703, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000140.1 Alternate HuRef

      Range
      31888288..31902749, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC091144.12 (20927..35008) None
    genomic CH471080.2 EAW63397.1
      EAW63398.1
      EAW63399.1
    genomic CS300619.1 CAK32283.1
    mRNA AI890434.1 None
    mRNA AK026916.1 BAB15590.1
    mRNA AK308918.1 None
    mRNA AL530920.3 None
    mRNA BC007387.2 AAH07387.1
    mRNA BC066935.1 AAH66935.1
    mRNA BX648410.1 None
    mRNA DA617987.1 None
    mRNA DB047280.1 None
    mRNA DB112682.1 None
    mRNA DB113350.1 None
    other-genetic JF432833.1 ADZ16050.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6NXR4.1 GenPept UniProtKB/Swiss-Prot:Q6NXR4
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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