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    SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 [ Homo sapiens (human) ]

    Gene ID: 80176, updated on 13-Jun-2013
    Official Symbol
    SPSB1provided by HGNC
    Official Full Name
    splA/ryanodine receptor domain and SOCS box containing 1provided by HGNC
    Primary source
    HGNC:30628
    Locus tag
    RP3-324M8.1
    See related
    Ensembl:ENSG00000171621; HPRD:18106; MIM:611657; Vega:OTTHUMG00000001279
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SSB1; SSB-1
    Location :
    1p36.22
    Sequence :
    Chromosome: 1; NC_000001.10 (9352941..9429591)
    See SPSB1 in Epigenomics, MapViewer

    Chromosome 1 - NC_000001.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC727721 Neighboring gene hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) Neighboring gene uncharacterized LOC100506022 Neighboring gene solute carrier family 25 (pyrimidine nucleotide carrier), member 33 Neighboring gene ribosomal protein L9 pseudogene 11

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. Proteomic analysis of the NOS2 interactome in human airway epithelial cells. Foster MW, et al. Nitric Oxide, 2013 Feb 21. PMID 23438482.
    2. GWAS of dental caries patterns in the permanent dentition. Shaffer JR, et al. J Dent Res, 2013 Jan. PMID 23064961.
    3. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. Taipale M, et al. Cell, 2012 Aug 31. PMID 22939624.
    4. A genome-wide association study of host genetic determinants of the antibody response to Anthrax Vaccine Adsorbed. Pajewski NM, et al. Vaccine, 2012 Jul 6. PMID 22658931.
    5. Genome-wide association analysis implicates the involvement of eight loci with response to tocilizumab for the treatment of rheumatoid arthritis. Wang J, et al. Pharmacogenomics J, 2013 Jun. PMID 22491018.

    See all (29) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    2. SSB1/2 is part of an ssDNA-binding heterotrimeric complex, SOSS which is involved in the maintenance of genome stability.
      Title: SOSS complexes participate in the maintenance of genomic stability.
    Submit: New GeneRIF Correction

    Review eQTL and phenotype association data in this region using PheGenI

    Products Interactant Other Gene Complex Source Pubs Description
    Q96BD6 P08581 MET    HPRD  PubMed  
    Q96BD6 P20936 RASA1    HPRD  PubMed  
    BioGRID:123158 BioGRID:106962 ATM    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:123158 BioGRID:113743 CUL5    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:123158 BioGRID:120009 DDX4    BioGRID  PubMed Protein-peptide 
    BioGRID:123158 BioGRID:199085 Ddx4    BioGRID  PubMed Co-crystal Structure 
    BioGRID:123158 BioGRID:108309 ELAVL1    BioGRID  PubMed Affinity Capture-RNA 
    BioGRID:123158 BioGRID:109552 HSP90AA1    BioGRID  PubMed Affinity Capture-Luminescence 
    BioGRID:123158 BioGRID:110391 MET    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:123158 BioGRID:110906 NOS2    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-localization; Reconstituted Complex 
    BioGRID:123158 BioGRID:111108 PAWR    BioGRID  PubMed Protein-peptide 
    BioGRID:123158 BioGRID:227870 Pawr    BioGRID  PubMed Co-crystal Structure 
    BioGRID:123158 BioGRID:111856 RASA1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:123158 BioGRID:114977 RNF7    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:123158 BioGRID:112783 TCEB1    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:123158 BioGRID:112785 TCEB2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:123158 BioGRID:113010 TP53    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:123158 BioGRID:113014 TP73    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:123158 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem (from REACTOME)
      Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystemIntracellular foreign or aberrant host proteins are cleaved into peptide fragments of a precise size, such that they can be loaded on to class I MHC molecules and presented externally to cytotoxic T ...
    • Class I MHC mediated antigen processing & presentation, organism-specific biosystem (from REACTOME)
      Class I MHC mediated antigen processing & presentation, organism-specific biosystemMajor histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular b...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    Preferred Names
    SPRY domain-containing SOCS box protein 1
    Names
    SPRY domain-containing SOCS box protein 1
    novel SPRY domain containing protein
    SPRY domain-containing SOCS box protein SSB-1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025106.3 → NP_079382.2  SPRY domain-containing SOCS box protein 1

      Status: VALIDATED

      Source sequence(s)
      AL008734, AL358252, BC015711, DB242202
      Consensus CDS
      CCDS102.1
      UniProtKB/Swiss-Prot
      Q96BD6
      Related
      ENSP00000330221, OTTHUMP00000001398, ENST00000328089, OTTHUMT00000003727
      Conserved Domains (2) summary
      cd03744
      Location:232 – 273
      Blast Score: 212
      SOCS_SSB1; SOCS (suppressors of cytokine signaling) box of SSB1 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 has been shown to bind to MET, the receptor protein-tyrosine kinase for ...
      smart00449
      Location:95 – 226
      Blast Score: 196
      SPRY; Domain in SPla and the RYanodine Receptor.

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000001.10 Reference GRCh37.p10 Primary Assembly

      Range
      9352941..9429591
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000133.1 Alternate HuRef

      Range
      8547970..8579365
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018912.1 Alternate CHM1_1.0

      Range
      9418135..9449565
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    genomic ABBA01035551.1 (38613..70008) None
    genomic AL008734.10 None
    genomic AL358252.13 (100..2991) None
    genomic AMYH01000239.1 (103370..134800) None
    genomic CH471130.1 EAW71617.1
      EAW71618.1
    mRNA AB209559.1 BAD92796.1
    mRNA AF131840.1 None
    mRNA AF403026.1 AAL57345.1
    mRNA AK026046.1 BAB15335.1
    mRNA AK130055.1 BAC85287.1
    mRNA AK225417.1 None
    mRNA BC005852.2 AAH05852.2
    mRNA BC015711.1 AAH15711.1
    mRNA DB242202.1 None
    other-genetic HQ447409.1 ADQ31895.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96BD6.1 GenPept UniProtKB/Swiss-Prot:Q96BD6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Related information

      • Order cDNA clone
        Order cDNA clone
      • 3D structures
        3D structure of a gene
      • BioAssay
        Related PubChem BioAssays
      • BioProjects
        BioProjects related to a gene
      • BioSystems
        BioSystems
      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • dbVar
        Link from Gene to dbVar
      • EST
        Link to related EST entry
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • Nucleotide
        Link to related Nucleotide entry
      • OMIM
        Links between OMIM and Gene are calculated by Gene based on MIM numbers included in the summary and phenotype sections of the Gene record.
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed (OMIM)
        Links are provided when Gene has a link to a record in OMIM, and OMIM explicitly cites these publications in PubMed.
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
      • SNP: Genotype
        Gene Genotype Report
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

      Links to other resources

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