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    NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit [ Homo sapiens (human) ]

    Gene ID: 80155, updated on 14-May-2013
    Official Symbol
    NAA15provided by HGNC
    Official Full Name
    N(alpha)-acetyltransferase 15, NatA auxiliary subunitprovided by HGNC
    Primary source
    HGNC:30782
    See related
    Ensembl:ENSG00000164134; HPRD:10471; MIM:608000; Vega:OTTHUMG00000137363
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Ga19; NATH; NARG1; TBDN100
    Summary
    This gene encodes a protein of unknown function. However, similarity to proteins in yeast and other species suggests that this protein may be an N-acetyltransferase. [provided by RefSeq, Jul 2008]
    Location :
    4q31.1
    Sequence :
    Chromosome: 4; NC_000004.11 (140222676..140311935)
    See NAA15 in Epigenomics, MapViewer

    Chromosome 4 - NC_000004.11Genomic Context describing neighboring genes Neighboring gene E74-like factor 2 (ets domain transcription factor) Neighboring gene protein phosphatase 1, regulatory (inhibitor) subunit 14B pseudogene 3 Neighboring gene mitochondria-localized glutamic acid-rich protein Neighboring gene NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa Neighboring gene glucose-fructose oxidoreductase domain containing 2 pseudogene Neighboring gene RAB33B, member RAS oncogene family

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. Povlsen LK, et al. Nat Cell Biol, 2012 Oct. PMID 23000965.
    2. A census of human soluble protein complexes. Havugimana PC, et al. Cell, 2012 Aug 31. PMID 22939629.
    3. A high-throughput approach for measuring temporal changes in the interactome. Kristensen AR, et al. Nat Methods, 2012 Sep. PMID 22863883.
    4. Proteomic analysis of α4β1 integrin adhesion complexes reveals α-subunit-dependent protein recruitment. Byron A, et al. Proteomics, 2012 Jul. PMID 22623428.
    5. Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription. Tsai YC, et al. Mol Cell Proteomics, 2012 May. PMID 22586326.

    See all (36) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Data indicate that the physical interaction between HYPK and NatA Naa10/15 seems to be of functional importance both for huntingtin aggregation and for N-terminal acetylation.
      Title: The chaperone-like protein HYPK acts together with NatA in cotranslational N-terminal acetylation and prevention of Huntingtin aggregation.
    2. Essential role in cell survival through protein N-alpha-acetylation.
      Title: Induction of apoptosis in human cells by RNAi-mediated knockdown of hARD1 and NATH, components of the protein N-alpha-acetyltransferase complex.
    3. NATH, a novel gene overexpressed in papillary thyroid carcinomas.
      Title: NATH, a novel gene overexpressed in papillary thyroid carcinomas.
    4. levels of endogenous NATH and hARD1 proteins in thyroid papillary carcinoma patients; results suggest that NATH positively affects the level of hARD1 protein both in vivo and in cell cultures
      Title: Expression of N-acetyl transferase human and human Arrest defective 1 proteins in thyroid neoplasms.
    5. description of the human homologue of Nat1p, NATH (NAT human), as the binding partner of the hARD1 (human ARD1) protein
      Title: Identification and characterization of the human ARD1-NATH protein acetyltransferase complex.
    6. Loss of retinal endothelial Tbdn-1 expression may be a contributing factor in retinal blood vessel proliferation in retinopathy of prematurity.
      Title: Tubedown-1 (Tbdn-1) suppression in oxygen-induced retinopathy and in retinopathy of prematurity.
    7. NATH complexes with hARD1 in a ribosomal associated protein-N-acetyltransferase complex.
      Title: Identification and characterization of the human ARD1-NATH protein acetyltransferase complex.
    Submit: New GeneRIF Correction

    Review eQTL and phenotype association data in this region using PheGenI

    Products Interactant Other Gene Complex Source Pubs Description
    Q9BXJ9 ARD1 homolog B NAA11    HPRD  PubMed  
    Q9BXJ9 P13010 XRCC5    HPRD  PubMed  
    Q9BXJ9 P12956 XRCC6    HPRD  PubMed  
    BioGRID:123146 BioGRID:120846 ASUN    BioGRID  PubMed Co-fractionation 
    BioGRID:123146 BioGRID:124027 DDI2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123146 BioGRID:108621 FN1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123146 BioGRID:117304 HYPK    BioGRID  PubMed Affinity Capture-MS; Co-fractionation 
    BioGRID:123146 BioGRID:109883 ITGA4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123146 BioGRID:115126 MATR3    BioGRID  PubMed Co-fractionation 
    BioGRID:123146 BioGRID:113881 NAA10    BioGRID  PubMed Affinity Capture-MS; Co-fractionation 
    BioGRID:123146 BioGRID:207880 Naa10    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123146 BioGRID:217017 Naa15    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123146 BioGRID:111822 RAD21    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:123146 BioGRID:119602 SIRT7    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123146 BioGRID:112649 STAT1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123146 BioGRID:113108 TSNAX    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123146 BioGRID:122964 UBA5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123146 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123146 BioGRID:113255 VCAM1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123146 BioGRID:114930 VPS26A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123146 BioGRID:113353 XRCC5    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:123146 BioGRID:108822 XRCC6    BioGRID  PubMed Affinity Capture-Western 

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    N-acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    contributes_to ribosome binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    N-terminal protein amino acid acetylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    angiogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of transcription, DNA-dependent IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    transcription, DNA-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    transcription factor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Preferred Names
    N-alpha-acetyltransferase 15, NatA auxiliary subunit
    Names
    N-alpha-acetyltransferase 15, NatA auxiliary subunit
    tubedown-1
    protein tubedown-1
    NMDA receptor regulated 1
    gastric cancer antigen Ga19
    N-terminal acetyltransferase
    NMDA receptor-regulated protein 1
    transcriptional coactivator tubedown-100

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_057175.3 → NP_476516.1  N-alpha-acetyltransferase 15, NatA auxiliary subunit

      Status: VALIDATED

      Source sequence(s)
      AC097376, AY039242, AY112670, BC032642
      Consensus CDS
      CCDS43270.1
      UniProtKB/TrEMBL
      Q58F05
      UniProtKB/Swiss-Prot
      Q9BXJ9
      Related
      ENSP00000296543, OTTHUMP00000174300, ENST00000296543, OTTHUMT00000267839
      Conserved Domains (2) summary
      cd00189
      Location:47 – 145
      Blast Score: 106
      TPR; Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]-X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, ...
      pfam12569
      Location:187 – 698
      Blast Score: 1870
      NARP1; NMDA receptor-regulated protein 1

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000004.11 Reference GRCh37.p10 Primary Assembly

      Range
      140222676..140311935
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000136.1 Alternate HuRef

      Range
      135952782..136041659
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018915.1 Alternate CHM1_1.0

      Range
      140006295..140095558
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    genomic ABBA01069954.1 (12894..15162) None
    genomic ABBA01069955.1 None
    genomic ABBA01069956.1 None
    genomic ABBA01069957.1 None
    genomic ABBA01069958.1 None
    genomic AC097376.3 AAY40950.1
    genomic AMYH01014571.1 (98042..187305) None
    genomic CH471056.2 EAX05118.1
      EAX05119.1
      EAX05120.1
    mRNA AF327722.1 AAK15707.1
    mRNA AJ314788.1 CAC43228.1
    mRNA AK001595.1 None
    mRNA AK023387.1 None
    mRNA AK023402.1 BAB14562.1
    mRNA AK304417.1 BAG65248.1
    mRNA AK314626.1 BAG37192.1
    mRNA AY039242.1 AAK68661.1
    mRNA AY112670.1 AAM48746.1
    mRNA BC032642.1 AAH32642.1
    mRNA BC039818.1 AAH39818.1
    mRNA BC093928.1 AAH93928.1
    mRNA BC104806.1 AAI04807.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9BXJ9.1 GenPept UniProtKB/Swiss-Prot:Q9BXJ9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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      Supplemental Content

      Table of contents

      Related information

      • Order cDNA clone
        Order cDNA clone
      • BioAssay
        Related PubChem BioAssays
      • BioProjects
        BioProjects related to a gene
      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • dbVar
        Link from Gene to dbVar
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • Nucleotide
        Link to related Nucleotide entry
      • OMIM
        Links between OMIM and Gene are calculated by Gene based on MIM numbers included in the summary and phenotype sections of the Gene record.
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed (OMIM)
        Links are provided when Gene has a link to a record in OMIM, and OMIM explicitly cites these publications in PubMed.
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
      • SNP: Genotype
        Gene Genotype Report
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

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