Format

Send to:

Choose Destination

MAP3K19 mitogen-activated protein kinase kinase kinase 19 [ Homo sapiens (human) ]

Gene ID: 80122, updated on 26-May-2016
Official Symbol
MAP3K19provided by HGNC
Official Full Name
mitogen-activated protein kinase kinase kinase 19provided by HGNC
Primary source
HGNC:HGNC:26249
See related
Ensembl:ENSG00000176601 HPRD:08016; Vega:OTTHUMG00000074083
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RCK; YSK4
Orthologs
Location:
2q21.3
Exon count:
20
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 2 NC_000002.12 (134964290..135047444, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (135722076..135782301, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene CCNT2 antisense RNA 1 Neighboring gene aminocarboxymuconate semialdehyde decarboxylase Neighboring gene cyclin T2 Neighboring gene RAB3 GTPase activating protein catalytic subunit 1 Neighboring gene uncharacterized LOC105373631 Neighboring gene zinc finger RANBP2-type containing 3

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ23074

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
receptor signaling protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
 
signal transduction by protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
Preferred Names
mitogen-activated protein kinase kinase kinase 19
Names
SPS1/STE20-related protein kinase YSK4
YSK4 Sps1/Ste20-related kinase homolog
regulated in COPD kinase
regulated in COPD, protein kinase
yeast Sps1/Ste20-related kinase 4
NP_001018054.1
NP_001018056.1
NP_001018057.1
NP_001269812.1
NP_079328.3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001018044.2NP_001018054.1  mitogen-activated protein kinase kinase kinase 19 isoform 3

    See identical proteins and their annotated locations for NP_001018054.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two alternate exons that result in the loss of an in-frame segment in the 5' coding region, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AC016725, AY574902, BU676900
    Consensus CDS
    CCDS63020.1
    UniProtKB/Swiss-Prot
    Q56UN5
    Related
    ENSP00000351140, OTTHUMP00000083262, ENST00000358371, OTTHUMT00000158245
    Conserved Domains (2) summary
    smart00220
    Location:9481211
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06631
    Location:9461211
    STKc_YSK4; Catalytic domain of the Serine/Threonine Kinase, Yeast Sps1/Ste20-related Kinase 4
  2. NM_001018046.2NP_001018056.1  mitogen-activated protein kinase kinase kinase 19 isoform 2

    See identical proteins and their annotated locations for NP_001018056.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
    Source sequence(s)
    AC016725, AY574904, BU676900
    Consensus CDS
    CCDS33293.1
    UniProtKB/Swiss-Prot
    Q56UN5
    Related
    ENSP00000365004, OTTHUMP00000083263, ENST00000375844, OTTHUMT00000158246
    Conserved Domains (2) summary
    smart00220
    Location:243506
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06631
    Location:241506
    STKc_YSK4; Catalytic domain of the Serine/Threonine Kinase, Yeast Sps1/Ste20-related Kinase 4
  3. NM_001018047.2NP_001018057.1  mitogen-activated protein kinase kinase kinase 19 isoform 4

    See identical proteins and their annotated locations for NP_001018057.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon in the central coding region, and uses two alternate splice sites that result in the loss of an in-frame segment in the 3' coding region, compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
    Source sequence(s)
    AC016725, AY574905, BU676900
    Consensus CDS
    CCDS63022.1
    UniProtKB/Swiss-Prot
    Q56UN5
    Related
    ENSP00000376650, OTTHUMP00000083264, ENST00000392918, OTTHUMT00000158247
    Conserved Domains (2) summary
    smart00220
    Location:227458
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:246458
    PKc_like; Protein Kinases, catalytic domain
  4. NM_001282883.1NP_001269812.1  mitogen-activated protein kinase kinase kinase 19 isoform 5

    See identical proteins and their annotated locations for NP_001269812.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks two alternate exons that result in the loss of an in-frame segment in the central coding region, compared to variant 1. The encoded isoform (5) is shorter than isoform 1.
    Source sequence(s)
    AC016725, AC020602, BC144555, BU676900
    Consensus CDS
    CCDS63021.1
    UniProtKB/Swiss-Prot
    Q56UN5
    Related
    ENSP00000376649, ENST00000392917
    Conserved Domains (2) summary
    smart00220
    Location:206456
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06631
    Location:206456
    STKc_YSK4; Catalytic domain of the Serine/Threonine Kinase, Yeast Sps1/Ste20-related Kinase 4
  5. NM_001321177.1NP_001308106.1  mitogen-activated protein kinase kinase kinase 19 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC016725, AK122935, BC034417, BC137277
    Conserved Domains (1) summary
    cl21453
    Location:10761092
    PKc_like; Protein Kinases, catalytic domain
  6. NM_025052.4NP_079328.3  mitogen-activated protein kinase kinase kinase 19 isoform 1

    See identical proteins and their annotated locations for NP_079328.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC016725, AY574901, BU676900
    Consensus CDS
    CCDS2176.2
    UniProtKB/Swiss-Prot
    Q56UN5
    Related
    ENSP00000365005, OTTHUMP00000083261, ENST00000375845, OTTHUMT00000158244
    Conserved Domains (2) summary
    smart00220
    Location:10611324
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06631
    Location:10591324
    STKc_YSK4; Catalytic domain of the Serine/Threonine Kinase, Yeast Sps1/Ste20-related Kinase 4

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p2 Primary Assembly

    Range
    134964290..135047444 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011511895.1XP_011510197.1  

    Conserved Domains (2) summary
    smart00220
    Location:9221185
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06631
    Location:9201185
    STKc_YSK4; Catalytic domain of the Serine/Threonine Kinase, Yeast Sps1/Ste20-related Kinase 4
  2. XM_011511891.1XP_011510193.1  

    Conserved Domains (2) summary
    smart00220
    Location:10781341
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06631
    Location:10761341
    STKc_YSK4; Catalytic domain of the Serine/Threonine Kinase, Yeast Sps1/Ste20-related Kinase 4
  3. XM_011511894.1XP_011510196.1  

    Conserved Domains (2) summary
    smart00220
    Location:10331296
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06631
    Location:10311296
    STKc_YSK4; Catalytic domain of the Serine/Threonine Kinase, Yeast Sps1/Ste20-related Kinase 4
  4. XM_011511896.1XP_011510198.1  

    See identical proteins and their annotated locations for XP_011510198.1

    Conserved Domains (2) summary
    smart00220
    Location:9661229
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06631
    Location:9641229
    STKc_YSK4; Catalytic domain of the Serine/Threonine Kinase, Yeast Sps1/Ste20-related Kinase 4
  5. XM_011511897.1XP_011510199.1  

    See identical proteins and their annotated locations for XP_011510199.1

    Conserved Domains (2) summary
    smart00220
    Location:9661229
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06631
    Location:9641229
    STKc_YSK4; Catalytic domain of the Serine/Threonine Kinase, Yeast Sps1/Ste20-related Kinase 4
  6. XM_011511892.1XP_011510194.1  

    See identical proteins and their annotated locations for XP_011510194.1

    UniProtKB/Swiss-Prot
    Q56UN5
    Conserved Domains (2) summary
    smart00220
    Location:10611324
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06631
    Location:10591324
    STKc_YSK4; Catalytic domain of the Serine/Threonine Kinase, Yeast Sps1/Ste20-related Kinase 4
  7. XM_006712774.2XP_006712837.1  

    See identical proteins and their annotated locations for XP_006712837.1

    UniProtKB/Swiss-Prot
    Q56UN5
    Conserved Domains (2) summary
    smart00220
    Location:10611324
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06631
    Location:10591324
    STKc_YSK4; Catalytic domain of the Serine/Threonine Kinase, Yeast Sps1/Ste20-related Kinase 4
  8. XM_011511899.1XP_011510201.1  

    See identical proteins and their annotated locations for XP_011510201.1

    UniProtKB/Swiss-Prot
    Q56UN5
    Conserved Domains (2) summary
    smart00220
    Location:10611324
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06631
    Location:10591324
    STKc_YSK4; Catalytic domain of the Serine/Threonine Kinase, Yeast Sps1/Ste20-related Kinase 4
  9. XM_011511893.1XP_011510195.1  

    See identical proteins and their annotated locations for XP_011510195.1

    UniProtKB/Swiss-Prot
    Q56UN5
    Conserved Domains (2) summary
    smart00220
    Location:10611324
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06631
    Location:10591324
    STKc_YSK4; Catalytic domain of the Serine/Threonine Kinase, Yeast Sps1/Ste20-related Kinase 4
  10. XM_011511900.1XP_011510202.1  

  11. XM_011511898.1XP_011510200.1  

    Conserved Domains (1) summary
    cl21453
    Location:10591075
    PKc_like; Protein Kinases, catalytic domain
  12. XM_011511901.1XP_011510203.1  

    UniProtKB/TrEMBL
    A8MWG7
    Related
    ENSP00000376647, OTTHUMP00000082723, ENST00000392915, OTTHUMT00000157282
    Conserved Domains (1) summary
    cl21453
    Location:10761092
    PKc_like; Protein Kinases, catalytic domain

Alternate CHM1_1.1

Genomic

  1. NC_018913.2 Alternate CHM1_1.1

    Range
    135726928..135787128 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001018045.1: Suppressed sequence

    Description
    NM_001018045.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.