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DOCK5 dedicator of cytokinesis 5 [ Homo sapiens (human) ]

Gene ID: 80005, updated on 26-Jun-2015
Official Symbol
DOCK5provided by HGNC
Official Full Name
dedicator of cytokinesis 5provided by HGNC
Primary source
HGNC:HGNC:23476
See related
Ensembl:ENSG00000147459; HPRD:09925; Vega:OTTHUMG00000131991
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Orthologs
See DOCK5 in Epigenomics, MapViewer
Location:
8p21.2
Exon count:
53
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 8 NC_000008.11 (25184772..25415716)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (25042287..25273227)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105379330 Neighboring gene ependymin related 1 pseudogene Neighboring gene uncharacterized LOC105379331 Neighboring gene microRNA 6876 Neighboring gene gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) Neighboring gene potassium channel tetramerization domain containing 9

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Factors involved in megakaryocyte development and platelet production, organism-specific biosystem (from REACTOME)
    Factors involved in megakaryocyte development and platelet production, organism-specific biosystemMegakaryocytes (MKs) give rise to circulating platelets (thrombocytes) through terminal differentiation of MKs which release cytoplasmic fragments as circulating platelets. As MKs mature they underg...
  • Hemostasis, organism-specific biosystem (from REACTOME)
    Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • DKFZp451J181, DKFZp779M164, DKFZp781J211

Gene Ontology Provided by GOA

Function Evidence Code Pubs
guanyl-nucleotide exchange factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of GTPase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
small GTPase mediated signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
Preferred Names
dedicator of cytokinesis protein 5
Names
dedicator of cytokinesis protein 5

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024940.6NP_079216.4  dedicator of cytokinesis protein 5

    See identical proteins and their annotated locations for NP_079216.4

    Status: VALIDATED

    Source sequence(s)
    AC091185, AK024687, AK026663, AK126249, BC011877, BC041761, BF884637, BX648352, CR627414, CR749353
    Consensus CDS
    CCDS6047.1
    UniProtKB/TrEMBL
    Q68DL4
    UniProtKB/Swiss-Prot
    Q9H7D0
    Conserved Domains (3) summary
    cd11708
    Location:12381637
    DHR2_DOCK5; Dock Homology Region 2, a GEF domain, of Class A Dedicator of Cytokinesis 5
    cd12051
    Location:1267
    SH3_DOCK1_5_A; Src Homology 3 domain of Class A Dedicator of Cytokinesis proteins 1 and 5
    cl14603
    Location:442637
    C2; C2 domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p2 Primary Assembly

    Range
    25184772..25415716
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011544661.1XP_011542963.1  

    Related
    ENSP00000276440, OTTHUMP00000162832, ENST00000276440, OTTHUMT00000254955
    Conserved Domains (3) summary
    cd11708
    Location:12451644
    DHR2_DOCK5; Dock Homology Region 2, a GEF domain, of Class A Dedicator of Cytokinesis 5
    cd12051
    Location:1267
    SH3_DOCK1_5_A; Src Homology 3 domain of Class A Dedicator of Cytokinesis proteins 1 and 5
    cl14603
    Location:442637
    C2; C2 domain
  2. XM_011544662.1XP_011542964.1  

    Conserved Domains (3) summary
    cd11708
    Location:12451644
    DHR2_DOCK5; Dock Homology Region 2, a GEF domain, of Class A Dedicator of Cytokinesis 5
    cd12051
    Location:1267
    SH3_DOCK1_5_A; Src Homology 3 domain of Class A Dedicator of Cytokinesis proteins 1 and 5
    cl14603
    Location:442637
    C2; C2 domain
  3. XM_011544663.1XP_011542965.1  

    Conserved Domains (3) summary
    cd11708
    Location:12451644
    DHR2_DOCK5; Dock Homology Region 2, a GEF domain, of Class A Dedicator of Cytokinesis 5
    cd12051
    Location:1267
    SH3_DOCK1_5_A; Src Homology 3 domain of Class A Dedicator of Cytokinesis proteins 1 and 5
    cl14603
    Location:442637
    C2; C2 domain
  4. XM_011544664.1XP_011542966.1  

    Conserved Domains (2) summary
    cd11708
    Location:11261525
    DHR2_DOCK5; Dock Homology Region 2, a GEF domain, of Class A Dedicator of Cytokinesis 5
    cl14603
    Location:323518
    C2; C2 domain

Alternate CHM1_1.1

Genomic

  1. NC_018919.2 Alternate CHM1_1.1

    Range
    25243660..25472059
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)