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reep1 receptor accessory protein 1 [ Danio rerio (zebrafish) ]

Gene ID: 799901, updated on 27-Mar-2024

Summary

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Official Symbol
reep1provided by ZNC
Official Full Name
receptor accessory protein 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-110411-267
See related
Ensembl:ENSDARG00000014854 AllianceGenome:ZFIN:ZDB-GENE-110411-267
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:dkey-21a6.4
Summary
Predicted to enable microtubule binding activity. Predicted to be involved in endoplasmic reticulum tubular network organization. Predicted to be integral component of membrane. Predicted to be active in cytoplasmic microtubule; endoplasmic reticulum membrane; and endoplasmic reticulum tubular network. Is expressed in brain and skeletal muscle. Human ortholog(s) of this gene implicated in distal hereditary motor neuronopathy type 5B and hereditary spastic paraplegia 31. Orthologous to human REEP1 (receptor accessory protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
chromosome: 17
Exon count:
8
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (43485999..43503775)
105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (43495534..43513583)

Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene heat shock protein 4 like Neighboring gene charged multivesicular body protein 3 Neighboring gene si:dkey-21a6.5 Neighboring gene mitochondrial ribosomal protein L35

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Converging Role for REEP1/SPG31 in Oxidative Stress. Naef V, et al. Int J Mol Sci, 2023 Feb 9. PMID 36834939, Free PMC Article
  2. Spastin mutations impair coordination between lipid droplet dispersion and reticulum. Arribat Y, et al. PLoS Genet, 2020 Apr. PMID 32315314, Free PMC Article
  3. REEP5 depletion causes sarco-endoplasmic reticulum vacuolization and cardiac functional defects. Lee SH, et al. Nat Commun, 2020 Feb 19. PMID 32075961, Free PMC Article
  4. Analysis of DNA methylation reveals a partial reprogramming of the Müller glia genome during retina regeneration. Powell C, et al. Proc Natl Acad Sci U S A, 2013 Dec 3. PMID 24248357, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Converging Role for REEP1/SPG31 in Oxidative Stress.
    Title: Converging Role for REEP1/SPG31 in Oxidative Stress.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in endoplasmic reticulum tubular network organization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasmic microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum tubular network IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
receptor expression-enhancing protein 1-like

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007128.7 Reference GRCz11 Primary Assembly

    Range
    43485999..43503775
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021467468.1 → XP_021323143.1  receptor expression-enhancing protein 1-like isoform X1

    UniProtKB/TrEMBL
    A0A8M9P9M3
    Related
    ENSDARP00000023771.8, ENSDART00000023953.8
    Conserved Domains (1) summary
    pfam03134
    Location:19 → 94
    TB2_DP1_HVA22; TB2/DP1, HVA22 family

  2. XM_001340171.6 → XP_001340207.3  receptor expression-enhancing protein 1-like isoform X2

    UniProtKB/TrEMBL
    A0A8M1PSF5, F8W555
    Related
    ENSDARP00000123784.1, ENSDART00000149041.2
    Conserved Domains (1) summary
    pfam03134
    Location:7 → 94
    TB2_DP1_HVA22; TB2/DP1, HVA22 family
Nucleotide Protein
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