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    KAT6A K(lysine) acetyltransferase 6A [ Homo sapiens (human) ]

    Gene ID: 7994, updated on 14-May-2013
    Official Symbol
    KAT6Aprovided by HGNC
    Official Full Name
    K(lysine) acetyltransferase 6Aprovided by HGNC
    Primary source
    HGNC:13013
    See related
    Ensembl:ENSG00000083168; HPRD:03244; MIM:601408; Vega:OTTHUMG00000150453
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MOZ; MYST3; ZNF220; RUNXBP2; ZC2HC6A
    Location :
    8p11
    Sequence :
    Chromosome: 8; NC_000008.10 (41786997..41909505, complement)
    See KAT6A in Epigenomics, MapViewer

    Chromosome 8 - NC_000008.10Genomic Context describing neighboring genes Neighboring gene NK6 homeobox 3 Neighboring gene microRNA 486 Neighboring gene ankyrin 1, erythrocytic Neighboring gene ribosomal protein L17 pseudogene 30 Neighboring gene myosin, light chain 9, regulatory pseudogene

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. MOZ increases p53 acetylation and premature senescence through its complex formation with PML. Rokudai S, et al. Proc Natl Acad Sci U S A, 2013 Mar 5. PMID 23431171.
    2. Tandem PHD fingers of MORF/MOZ acetyltransferases display selectivity for acetylated histone H3 and are required for the association with chromatin. Ali M, et al. J Mol Biol, 2012 Dec 14. PMID 23063713.
    3. Acute myeloid leukemia with translocation (8;16)(p11;p13) and MYST3-CREBBP rearrangement harbors a distinctive microRNA signature targeting RET proto-oncogene. Díaz-Beyá M, et al. Leukemia, 2013 Mar. PMID 23022987.
    4. Combinatorial readout of unmodified H3R2 and acetylated H3K14 by the tandem PHD finger of MOZ reveals a regulatory mechanism for HOXA9 transcription. Qiu Y, et al. Genes Dev, 2012 Jun 15. PMID 22713874.
    5. Functional dissection of lysine deacetylases reveals that HDAC1 and p300 regulate AMPK. Lin YY, et al. Nature, 2012 Feb 8. PMID 22318606.

    See all (45) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. MYST3-CREBBP rearrangement harbors a distinctive microRNA signature targeting RET proto-oncogene in acute myeloid leukemia with translocation (8;16)(p11;p13).
      Title: Acute myeloid leukemia with translocation (8;16)(p11;p13) and MYST3-CREBBP rearrangement harbors a distinctive microRNA signature targeting RET proto-oncogene.
    2. MOZ is an acetyltransferase of p53 at K120 and K382 and colocalizes with p53 in promyelocytic leukemia (PML) nuclear bodies following cellular stress.
      Title: MOZ increases p53 acetylation and premature senescence through its complex formation with PML.
    3. These data suggest that the tandem of plant homeodomain 1/2 fingers play a role in MOZ and MORF histone acetyltransferase association with histon H3 regions enriched in acetylated marks.
      Title: Tandem PHD fingers of MORF/MOZ acetyltransferases display selectivity for acetylated histone H3 and are required for the association with chromatin.
    4. PHD12 facilitates the localization of MOZ onto the promoter locus of the HOXA9 gene, thereby promoting the H3 acetylation around the promoter region.
      Title: Combinatorial readout of unmodified H3R2 and acetylated H3K14 by the tandem PHD finger of MOZ reveals a regulatory mechanism for HOXA9 transcription.
    5. Recognition of unmodified histone H3 by the first PHD finger of bromodomain-PHD finger protein 2 provides insights into the regulation of histone acetyltransferases monocytic leukemic zinc-finger protein (MOZ) and MOZ-related factor (MORF).
      Title: Recognition of unmodified histone H3 by the first PHD finger of bromodomain-PHD finger protein 2 provides insights into the regulation of histone acetyltransferases monocytic leukemic zinc-finger protein (MOZ) and MOZ-related factor (MORF).
    6. Observational study of gene-disease association. (HuGE Navigator)
      Title: Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.
    7. The role of the interaction between MOZ and MLL in CD34+ cells in which both proteins have a critical role in hematopoietic cell-fate decision.
      Title: Crosstalk between leukemia-associated proteins MOZ and MLL regulates HOX gene expression in human cord blood CD34+ cells.
    8. MOZ-TIF2 oncogenic fusion protein suppresses transcription by nuclear receptors and p53
      Title: MOZ-TIF2 inhibits transcription by nuclear receptors and p53 by impairment of CBP function.
    9. Monocytic leukemia zinc finger (MOZ) interacts with p53 to induce p21 expression and cell-cycle arrest.
      Title: Monocytic leukemia zinc finger (MOZ) interacts with p53 to induce p21 expression and cell-cycle arrest.
    10. a gain of the MYB locus, was found recurrently and only in the MYST3-linked AMLs (7/18 vs 0/34). MYST3-AMLs have also a specific a gene expression profile, which includes overexpression of MYB, CD4 and HOXA genes
      Title: Genome profiling of acute myelomonocytic leukemia: alteration of the MYB locus in MYST3-linked cases.
    Submit: New GeneRIF Correction See all (17)

    Review eQTL and phenotype association data in this region using PheGenI

    Protein Gene Interaction Pubs
    pol gag-pol Cellular acetyltransferase binds HIV-1 integrase both in vitro and in cells and acetylates three specific lysine's (K264, K266, K273) in the carboxy-terminus of integrase PubMed

    Go to the HIV-1, Human Protein Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description
    Q92794 P54259 ATN1    HPRD  PubMed  
    Q92794 P54253 ATXN1    HPRD  PubMed  
    Q92794 Q9P2R6 RERE    HPRD  PubMed  
    Q92794 Q01196 RUNX1    HPRD  PubMed  
    Q92794 P17947 SPI1    HPRD  PubMed  
    BioGRID:113703 BioGRID:108156 ATN1    BioGRID  PubMed Two-hybrid 
    BioGRID:113703 BioGRID:112217 ATXN1    BioGRID  PubMed Two-hybrid 
    BioGRID:113703 BioGRID:113614 BRPF1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:113703 BioGRID:107777 CREBBP    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113703 BioGRID:108309 ELAVL1    BioGRID  PubMed Affinity Capture-RNA 
    BioGRID:113703 BioGRID:108347 EP300    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113703 BioGRID:108403 ESR1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113703 BioGRID:136289 H3F3C    BioGRID  PubMed Biochemical Activity 
    BioGRID:113703 BioGRID:109315 HDAC1    BioGRID  PubMed Positive Genetic 
    BioGRID:113703 BioGRID:109316 HDAC2    BioGRID  PubMed Negative Genetic 
    BioGRID:113703 BioGRID:114368 HDAC3    BioGRID  PubMed Positive Genetic 
    BioGRID:113703 BioGRID:115106 HDAC4    BioGRID  PubMed Negative Genetic 
    BioGRID:113703 BioGRID:120968 HDAC8    BioGRID  PubMed Positive Genetic 
    BioGRID:113703 BioGRID:113946 HIST1H3A    BioGRID  PubMed Biochemical Activity 
    BioGRID:113703 BioGRID:113955 HIST1H4A    BioGRID  PubMed Biochemical Activity 
    BioGRID:113703 BioGRID:113899 HIST1H4I    BioGRID  PubMed Biochemical Activity 
    BioGRID:113703 BioGRID:126025 HIST2H3C    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113703 BioGRID:113895 HIST3H3    BioGRID  PubMed Biochemical Activity; Reconstituted Complex 
    BioGRID:113703 BioGRID:109540 HSPA4    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:113703 BioGRID:124016 ING5    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:113703 BioGRID:110443 KMT2A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113703 BioGRID:113688 MAFK    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113703 BioGRID:122280 MEAF6    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113703 BioGRID:106963 RERE    BioGRID  PubMed Two-hybrid 
    BioGRID:113703 BioGRID:107309 RUNX1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity 
    BioGRID:113703 BioGRID:116980 SIRT5    BioGRID  PubMed Positive Genetic 
    BioGRID:113703 BioGRID:113010 TP53    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113703 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113703 BioGRID:127156 UBE2U    BioGRID  PubMed Two-hybrid 
    BioGRID:113703 BioGRID:116272 WDR5    BioGRID  PubMed Affinity Capture-Western 

    Markers

    Genotypes

    Homology

    Clone Names

    • MGC167033

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    histone acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    transcription coactivator activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    transcription factor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    zinc ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    DNA packaging TAS
    Traceable Author Statement
    more info
    		 PubMed 
    cellular senescence IMP
    Inferred from Mutant Phenotype
    more info
    		  
    embryonic hemopoiesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    histone H3 acetylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    histone acetylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    myeloid cell differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of transcription, DNA-dependent IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleosome assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of transcription, DNA-dependent IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein acetylation IDA
    Inferred from Direct Assay
    more info
    		  
    somatic stem cell maintenance IEA
    Inferred from Electronic Annotation
    more info
    		  
    transcription, DNA-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    MOZ/MORF histone acetyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    PML body IDA
    Inferred from Direct Assay
    more info
    		  
    nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Preferred Names
    histone acetyltransferase KAT6A
    Names
    histone acetyltransferase KAT6A
    MYST-3
    zinc finger protein 220
    histone acetyltransferase MYST3
    Monocytic leukemia zinc finger protein
    MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3
    runt-related transcription factor binding protein 2
    runt-related transcription factor-binding protein 2
    MYST histone acetyltransferase (monocytic leukemia) 3
    NP_001092882.1
    NP_001092883.1
    NP_006757.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001099412.1 → NP_001092882.1  histone acetyltransferase KAT6A

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 all encode the same protein.
      Source sequence(s)
      AC090571, BC142659, DA257528, U47742
      Consensus CDS
      CCDS6124.1
      UniProtKB/TrEMBL
      A5PKX7
      UniProtKB/Swiss-Prot
      Q92794
      Related
      ENSP00000380136, ENST00000396930
      Conserved Domains (4) summary
      PLN03238
      Location:505 – 778
      Blast Score: 905
      PLN03238; probable histone acetyltransferase MYST; Provisional
      smart00526
      Location:85 – 162
      Blast Score: 124
      H15; Domain in histone families 1 and 5
      pfam00628
      Location:262 – 313
      Blast Score: 158
      PHD; PHD-finger
      pfam01853
      Location:562 – 749
      Blast Score: 943
      MOZ_SAS; MOZ/SAS family

    2. NM_001099413.1 → NP_001092883.1  histone acetyltransferase KAT6A

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 all encode the same protein.
      Source sequence(s)
      AC090571, BC142659, BP348860, DA758316, U47742
      Consensus CDS
      CCDS6124.1
      UniProtKB/TrEMBL
      A5PKX7
      UniProtKB/Swiss-Prot
      Q92794
      Related
      ENSP00000385888, OTTHUMP00000197394, ENST00000406337, OTTHUMT00000318163
      Conserved Domains (4) summary
      PLN03238
      Location:505 – 778
      Blast Score: 905
      PLN03238; probable histone acetyltransferase MYST; Provisional
      smart00526
      Location:85 – 162
      Blast Score: 124
      H15; Domain in histone families 1 and 5
      pfam00628
      Location:262 – 313
      Blast Score: 158
      PHD; PHD-finger
      pfam01853
      Location:562 – 749
      Blast Score: 943
      MOZ_SAS; MOZ/SAS family

    3. NM_006766.3 → NP_006757.2  histone acetyltransferase KAT6A

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 all encode the same protein.
      Source sequence(s)
      AC090571, BC142659, DA442995, U47742
      Consensus CDS
      CCDS6124.1
      UniProtKB/TrEMBL
      A5PKX7
      UniProtKB/Swiss-Prot
      Q92794
      Related
      ENSP00000265713, OTTHUMP00000197392, ENST00000265713, OTTHUMT00000318160
      Conserved Domains (4) summary
      PLN03238
      Location:505 – 778
      Blast Score: 905
      PLN03238; probable histone acetyltransferase MYST; Provisional
      smart00526
      Location:85 – 162
      Blast Score: 124
      H15; Domain in histone families 1 and 5
      pfam00628
      Location:262 – 313
      Blast Score: 158
      PHD; PHD-finger
      pfam01853
      Location:562 – 749
      Blast Score: 943
      MOZ_SAS; MOZ/SAS family

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000008.10 Reference GRCh37.p10 Primary Assembly

      Range
      41786997..41909505, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000140.1 Alternate HuRef

      Range
      40314984..40434974, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018919.1 Alternate CHM1_1.0

      Range
      41860880..41983382, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    genomic ABBA01021142.1 (25951..75659) None
    genomic ABBA01021143.1 None
    genomic ABBA01021144.1 (1570..10649) None
    genomic AC090571.5 (15734..138214) None
    genomic AMYH01018676.1 (26059..148028) None
    genomic AMYH01018677.1 None
    genomic CH471080.2 EAW63239.1
      EAW63240.1
    mRNA AK027361.1 None
    mRNA AK128323.1 None
    mRNA BC018011.1 None
    mRNA BC142659.1 AAI42660.1
    mRNA BC142959.1 AAI42960.1
    mRNA BP348860.1 None
    mRNA DA257528.1 None
    mRNA DA442995.1 None
    mRNA DA758316.1 None
    mRNA U47742.1 AAC50662.1
    other-genetic BC172379.1 AAI72379.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q92794.2 GenPept UniProtKB/Swiss-Prot:Q92794

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Related information

      • Order cDNA clone
        Order cDNA clone
      • 3D structures
        3D structure of a gene
      • BioAssay
        Related PubChem BioAssays
      • BioProjects
        BioProjects related to a gene
      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • dbVar
        Link from Gene to dbVar
      • EST
        Link to related EST entry
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • Nucleotide
        Link to related Nucleotide entry
      • OMIM
        Links between OMIM and Gene are calculated by Gene based on MIM numbers included in the summary and phenotype sections of the Gene record.
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed (OMIM)
        Links are provided when Gene has a link to a record in OMIM, and OMIM explicitly cites these publications in PubMed.
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
      • SNP: Genotype
        Gene Genotype Report
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

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