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KAT6A K(lysine) acetyltransferase 6A [ Homo sapiens (human) ]

Gene ID: 7994, updated on 24-Aug-2015
Official Symbol
KAT6Aprovided by HGNC
Official Full Name
K(lysine) acetyltransferase 6Aprovided by HGNC
Primary source
HGNC:HGNC:13013
See related
Ensembl:ENSG00000083168; HPRD:03244; MIM:601408; Vega:OTTHUMG00000150453
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MOZ; MRD32; MYST3; MYST-3; ZNF220; RUNXBP2; ZC2HC6A
Summary
This gene encodes a member of the MOZ, YBFR2, SAS2, TIP60 family of histone acetyltransferases. The protein is composed of a nuclear localization domain, a double C2H2 zinc finger domain that binds to acetylated histone tails, a histone acetyl-transferase domain, a glutamate/aspartate-rich region, and a serine- and methionine-rich transactivation domain. It is part of a complex that acetylates lysine-9 residues in histone 3, and in addition, it acts as a co-activator for several transcription factors. Allelic variants of this gene are associated with autosomal dominant mental retardation-32. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Orthologs
See KAT6A in Epigenomics, MapViewer
Location:
8p11
Exon count:
19
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 8 NC_000008.11 (41929479..42051989, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (41786997..41909506, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene microRNA 486-1 Neighboring gene microRNA 486-2 Neighboring gene ankyrin 1, erythrocytic Neighboring gene uncharacterized LOC105379392 Neighboring gene uncharacterized LOC105379394 Neighboring gene uncharacterized LOC105379393 Neighboring gene myosin, light chain 9, regulatory pseudogene Neighboring gene ribosomal protein L17 pseudogene 30

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Replication interactions

Interaction Pubs
Knockdown of K(lysine) acetyltransferase 6A (KAT6A) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Protein interactions

Protein Gene Interaction Pubs
integrase gag-pol Cellular acetyltransferase binds HIV-1 integrase both in vitro and in cells and acetylates three specific lysine's (K264, K266, K273) in the carboxy-terminus of integrase PubMed

Go to the HIV-1, Human Interaction Database

  • Chromatin modifying enzymes, organism-specific biosystem (from REACTOME)
    Chromatin modifying enzymes, organism-specific biosystemEukaryotic DNA is associated with histone proteins and organized into a complex nucleoprotein structure called chromatin. This structure decreases the accessibility of DNA but also helps to protect i...
  • Chromatin organization, organism-specific biosystem (from REACTOME)
    Chromatin organization, organism-specific biosystemChromatin organization refers to the composition and conformation of complexes between DNA, protein and RNA. It is determined by processes that result in the specification, formation or maintenance o...
  • HATs acetylate histones, organism-specific biosystem (from REACTOME)
    HATs acetylate histones, organism-specific biosystemHistone acetyltransferases (HATs) involved in histone modifications are referred to as A-type or nuclear HATs. They can be grouped into at least four families based on sequence conservation within th...
  • Signaling pathways regulating pluripotency of stem cells, organism-specific biosystem (from KEGG)
    Signaling pathways regulating pluripotency of stem cells, organism-specific biosystemPluripotent stem cells (PSCs) are basic cells with an indefinite self-renewal capacity and the potential to generate all the cell types of the three germinal layers. The types of PSCs known to date i...
  • Signaling pathways regulating pluripotency of stem cells, conserved biosystem (from KEGG)
    Signaling pathways regulating pluripotency of stem cells, conserved biosystemPluripotent stem cells (PSCs) are basic cells with an indefinite self-renewal capacity and the potential to generate all the cell types of the three germinal layers. The types of PSCs known to date i...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC167033

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
acetyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
chromatin binding IEA
Inferred from Electronic Annotation
more info
 
histone acetyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription coactivator activity TAS
Traceable Author Statement
more info
PubMed 
transcription factor binding IDA
Inferred from Direct Assay
more info
PubMed 
zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
DNA packaging TAS
Traceable Author Statement
more info
PubMed 
aorta morphogenesis IEA
Inferred from Electronic Annotation
more info
 
cellular senescence IMP
Inferred from Mutant Phenotype
more info
PubMed 
chromatin organization TAS
Traceable Author Statement
more info
 
embryonic hemopoiesis IEA
Inferred from Electronic Annotation
more info
 
face morphogenesis IEA
Inferred from Electronic Annotation
more info
 
heart morphogenesis IEA
Inferred from Electronic Annotation
more info
 
histone H3 acetylation IDA
Inferred from Direct Assay
more info
PubMed 
histone acetylation IDA
Inferred from Direct Assay
more info
PubMed 
myeloid cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of sequence-specific DNA binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
nucleosome assembly IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
protein acetylation IDA
Inferred from Direct Assay
more info
PubMed 
somatic stem cell maintenance IEA
Inferred from Electronic Annotation
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
 
MOZ/MORF histone acetyltransferase complex IDA
Inferred from Direct Assay
more info
PubMed 
PML body IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleosome IEA
Inferred from Electronic Annotation
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
histone acetyltransferase KAT6A
Names
MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3
MYST histone acetyltransferase (monocytic leukemia) 3
histone acetyltransferase MYST3
monocytic leukemia zinc finger protein
runt-related transcription factor binding protein 2
zinc finger protein 220
NP_001092882.1
NP_001092883.1
NP_006757.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_042093.1 RefSeqGene

    Range
    5001..127548
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001305878.1NP_001292807.1  histone acetyltransferase KAT6A isoform 2

    See identical proteins and their annotated locations for NP_001292807.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks several exons in the 3' coding region and its 3' terminal exon extends past a splice site that is used in variant 1, resulting in differences in the 3' coding region and 3' UTR compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC090571, BC142959, BP248857, BP271264
    UniProtKB/TrEMBL
    A5PLL3
    Conserved Domains (5) summary
    cd04301
    Location:615665
    NAT_SF; N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate
    smart00526
    Location:85162
    H15; Domain in histone families 1 and 5
    pfam01853
    Location:562749
    MOZ_SAS; MOZ/SAS family
    cd15527
    Location:264310
    PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
    cd15618
    Location:205262
    PHD1_MOZ_MORF; PHD finger 1 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
  2. NM_006766.4NP_006757.2  histone acetyltransferase KAT6A isoform 1

    See identical proteins and their annotated locations for NP_006757.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AA310750, AC090571, AJ420560, BC142659, BP248857, CB216817, DA442995, U47742
    Consensus CDS
    CCDS6124.1
    UniProtKB/TrEMBL
    A5PKX7
    UniProtKB/Swiss-Prot
    Q92794
    Related
    ENSP00000265713, OTTHUMP00000197392, ENST00000265713, OTTHUMT00000318160
    Conserved Domains (6) summary
    cd04301
    Location:615665
    NAT_SF; N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate
    smart00526
    Location:85162
    H15; Domain in histone families 1 and 5
    pfam01853
    Location:562749
    MOZ_SAS; MOZ/SAS family
    pfam11593
    Location:17281976
    Med3; Mediator complex subunit 3 fungal
    cd15527
    Location:264310
    PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
    cd15618
    Location:205262
    PHD1_MOZ_MORF; PHD finger 1 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p2 Primary Assembly

    Range
    41929479..42051989
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011544659.1XP_011542961.1  

    Conserved Domains (6) summary
    cd04301
    Location:652702
    NAT_SF; N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate
    smart00526
    Location:85162
    H15; Domain in histone families 1 and 5
    pfam01853
    Location:599786
    MOZ_SAS; MOZ/SAS family
    pfam11593
    Location:17652013
    Med3; Mediator complex subunit 3 fungal
    cd15527
    Location:264310
    PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
    cd15618
    Location:205262
    PHD1_MOZ_MORF; PHD finger 1 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
  2. XM_011544656.1XP_011542958.1  

    See identical proteins and their annotated locations for XP_011542958.1

    Conserved Domains (5) summary
    smart00526
    Location:85162
    H15; Domain in histone families 1 and 5
    pfam01853
    Location:606793
    MOZ_SAS; MOZ/SAS family
    pfam11593
    Location:17722020
    Med3; Mediator complex subunit 3 fungal
    cd15527
    Location:264310
    PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
    cd15618
    Location:205262
    PHD1_MOZ_MORF; PHD finger 1 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
  3. XM_011544660.1XP_011542962.1  

    Conserved Domains (6) summary
    cd04301
    Location:621671
    NAT_SF; N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate
    smart00526
    Location:85162
    H15; Domain in histone families 1 and 5
    pfam01853
    Location:568755
    MOZ_SAS; MOZ/SAS family
    pfam11593
    Location:17341982
    Med3; Mediator complex subunit 3 fungal
    cd15527
    Location:264310
    PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
    cd15618
    Location:205262
    PHD1_MOZ_MORF; PHD finger 1 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
  4. XM_011544657.1XP_011542959.1  

    See identical proteins and their annotated locations for XP_011542959.1

    Conserved Domains (5) summary
    smart00526
    Location:85162
    H15; Domain in histone families 1 and 5
    pfam01853
    Location:606793
    MOZ_SAS; MOZ/SAS family
    pfam11593
    Location:17722020
    Med3; Mediator complex subunit 3 fungal
    cd15527
    Location:264310
    PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
    cd15618
    Location:205262
    PHD1_MOZ_MORF; PHD finger 1 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
  5. XM_011544658.1XP_011542960.1  

    See identical proteins and their annotated locations for XP_011542960.1

    Conserved Domains (5) summary
    smart00526
    Location:85162
    H15; Domain in histone families 1 and 5
    pfam01853
    Location:606793
    MOZ_SAS; MOZ/SAS family
    pfam11593
    Location:17722020
    Med3; Mediator complex subunit 3 fungal
    cd15527
    Location:264310
    PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
    cd15618
    Location:205262
    PHD1_MOZ_MORF; PHD finger 1 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)

Alternate CHM1_1.1

Genomic

  1. NC_018919.2 Alternate CHM1_1.1

    Range
    41835431..41957801
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001099412.1: Suppressed sequence

    Description
    NM_001099412.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
  2. NM_001099413.1: Suppressed sequence

    Description
    NM_001099413.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.