NANOG Nanog homeobox [Homo sapiens (human)] - Gene

Summary

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Official Symbol: NANOGprovided by HGNC
Official Full Name: Nanog homeoboxprovided by HGNC
Primary source: HGNC:20857
See related: Ensembl:ENSG00000111704; HPRD:06397; MIM:607937; Vega:OTTHUMG00000166019
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo

Genomic context

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Location :: 12p13.31

Sequence :: Chromosome: 12; NC_000012.11 (7941995..7948655)

See NANOG in Epigenomics, MapViewer

Chromosome 12 - NC_000012.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

Linc-RoR (long intergenic non-protein coding RNA regulator of reprogramming) regulates endogenous Oct4, Nanog, and Sox2 expression in self-renewing and differentiating human embryonic stem cells.
Title: Endogenous miRNA sponge lincRNA-RoR regulates Oct4, Nanog, and Sox2 in human embryonic stem cell self-renewal.
The sensitivity of cisplatin was decreased with increased expression of Nanog. Nanog expression could promote the proliferation and invasiveness of the cancer cells, and inhibit the apoptosis.
Title: Increased Nanog expression promotes tumor development and Cisplatin resistance in human esophageal cancer cells.
the islet's beta cells, expressing LGR5 and Nanog markers are the initiating cells of pancreas cancer and Nanog is a major biomarker for pancreatic ductal adenocarcinomas
Title: LGR5 and Nanog identify stem cell signature of pancreas beta cells which initiate pancreatic cancer.
Data suggest that expression of NANOG and Oct4/POU5F1B (POU class 5 homeobox 1B) is up-regulated in visceral adipose tissue stem cells in type 2 diabetes as compared to control; expression is also up-regulated in hyperglycemic conditions.
Title: A diabetic milieu promotes OCT4 and NANOG production in human visceral-derived adipose stem cells.
role of NANOG heterogeneity in human embryonic stem cell division
Title: Contribution of stochastic partitioning at human embryonic stem cell division to NANOG heterogeneity.
Data indicate that Nanog(high)/EpCAM(high) samples represent a tumor-initiating cells (TICs) subset which may be either M- or S-type, and which is separate from the CD44(high)/Oct-4A(high) subset observed only in M-type samples.
Title: Protein markers of cancer-associated fibroblasts and tumor-initiating cells reveal subpopulations in freshly isolated ovarian cancer ascites.
Data indicate that stem cell-related transcription factors Nanog, Oct-4 and Sox-2 were positively expressed in umbilical cord (UC)-mesenchymal stem cells (MSCs).
Title: Isolation and characterization of mesenchymal stem cells from whole human umbilical cord applying a single enzyme approach.
Co-localization of NANOG and OCT4 in human pre-implantation embryos from morula and blastocyst stages and in human embryonic stem cells
Title: Co-localization of NANOG and OCT4 in human pre-implantation embryos and in human embryonic stem cells.
NANOG was upregulated during malignant progression.
Title: Involvement of NANOG upregulation in malignant progression of human cells.
NANOG has potential as a predictor of survival for patients with ovarian carcinomas and may be involved in the mechanism of chemoresistance.
Title: Prognostic impact of the cancer stem cell-related marker NANOG in ovarian serous carcinoma.

Submit: New GeneRIF Correction See all (118)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Interactions

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Products	Interactant	Other Gene	Source	Pubs	Description
BioGRID:123000	BioGRID:124082	DOT1L	BioGRID	PubMed	Phenotypic Suppression
BioGRID:123000	BioGRID:115293	MED12	BioGRID	PubMed	Affinity Capture-Western; Two-hybrid
BioGRID:123000	BioGRID:124119	RHOXF2	BioGRID	PubMed	Two-hybrid
BioGRID:123000	BioGRID:121420	SALL4	BioGRID	PubMed	Affinity Capture-Western
BioGRID:123000	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-Western
BioGRID:123000	BioGRID:117074	ZNF281	BioGRID	PubMed	Affinity Capture-Western

Pathways from BioSystems

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Cardiac Progenitor Differentiation, organism-specific biosystem (from WikiPathways)
Cardiac Progenitor Differentiation, organism-specific biosystemFactors involved in the induction of cardiac differentiation in vitro and in vivo. This model was based on the below two review articles.
Proteoglycans in cancer, organism-specific biosystem (from KEGG)
Proteoglycans in cancer, organism-specific biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
Proteoglycans in cancer, conserved biosystem (from KEGG)
Proteoglycans in cancer, conserved biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
SIDS Susceptibility Pathways, organism-specific biosystem (from WikiPathways)
SIDS Susceptibility Pathways, organism-specific biosystemIn this model, we provide an integrated view of Sudden Infant Death Syndrome (SIDS) at the level of implicated tissues, signaling networks and genetics. The purpose of this model is to serve as an ov...
Wnt Signaling Pathway and Pluripotency, organism-specific biosystem (from WikiPathways)
Wnt Signaling Pathway and Pluripotency, organism-specific biosystemThis pathway was adapted from several resources and is designed to provide a theoretical frame-work for examining Wnt signaling and interacting components in the context of embryonic stem-cell plurip...

General gene information

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Markers

D8S2278 (e-PCR)
- UniSTS:473906

D8S2279 (e-PCR)
- UniSTS:473907

L18426 (e-PCR)
- UniSTS:34648

D15S971 (e-PCR), detects polymorphism
- UniSTS:50806

SHGC-156015 (e-PCR)
- UniSTS:182915

STS-M96982 (e-PCR)
- UniSTS:74382

NoName (e-PCR)
- UniSTS:484047

Homology

Homologs of the NANOG gene: The NANOG gene is conserved in chimpanzee, Rhesus monkey, cow, mouse, and rat.
Map Viewer (Mouse, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
DNA binding	IDA Inferred from Direct Assay more info	PubMed
sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
sequence-specific DNA binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
transcription corepressor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
cell differentiation	IEP Inferred from Expression Pattern more info	PubMed
cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
embryo development	IEP Inferred from Expression Pattern more info	PubMed
endodermal cell fate specification	IDA Inferred from Direct Assay more info
positive regulation of transcription from RNA polymerase II promoter	IDA Inferred from Direct Assay more info
regulation of cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of transcription, DNA-dependent	IDA Inferred from Direct Assay more info	PubMed
somatic stem cell maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
transcription, DNA-dependent	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
nucleolus	IDA Inferred from Direct Assay more info
nucleus	IC Inferred by Curator more info	PubMed
nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: homeobox protein NANOG

Names: homeobox protein NANOG; hNanog; homeobox transcription factor Nanog; homeobox transcription factor Nanog-delta 48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_024865.2 → NP_079141.2 homeobox protein NANOG

Status: VALIDATED

Source sequence(s)

AC006517

Consensus CDS

CCDS31736.1

UniProtKB/Swiss-Prot

Q9H9S0

Related

ENSP00000229307, OTTHUMP00000231725, ENST00000229307, OTTHUMT00000387480

Conserved Domains (1) summary

cd00086
Location:98 – 154
Blast Score: 167

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p10 Primary Assembly

Genomic

NC_000012.11 Reference GRCh37.p10 Primary Assembly

Range

7941995..7948655

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000144.1 Alternate HuRef

Range

7755619..7762294

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.0

Genomic

NC_018923.1 Alternate CHM1_1.0

Range

7825162..7831816

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	ABBA01012211.1 (25807..32482)	None
genomic	AC006517.46 (69668..76328)	None
genomic	AMYH01004219.1 (23794..30448)	None
genomic	CH471116.2	EAW88649.1
		EAW88650.1
		EAW88651.1
genomic	CQ860374.1	CAH25962.1
mRNA	AB093576.1	BAC76999.1
mRNA	AK022643.1	BAB14151.1
mRNA	AK290896.1	BAF83585.1
mRNA	AY230262.1	AAP49529.1
mRNA	AY578089.1	AAT81526.1
mRNA	BC069807.1	None
mRNA	BC098275.1	None
mRNA	BC099704.1	None
other-genetic	BC160187.1	AAI60187.1
other-genetic	EU446847.1	ABZ92376.1