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CALCR calcitonin receptor [ Homo sapiens (human) ]

Gene ID: 799, updated on 26-May-2016
Official Symbol
CALCRprovided by HGNC
Official Full Name
calcitonin receptorprovided by HGNC
Primary source
HGNC:HGNC:1440
See related
Ensembl:ENSG00000004948 HPRD:00239; MIM:114131; Vega:OTTHUMG00000023599
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CRT; CTR; CT-R; CTR1
Summary
This gene encodes a high affinity receptor for the peptide hormone calcitonin and belongs to a subfamily of seven transmembrane-spanning G protein-coupled receptors. The encoded protein is involved in maintaining calcium homeostasis and in regulating osteoclast-mediated bone resorption. Polymorphisms in this gene have been associated with variations in bone mineral density and onset of osteoporosis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]
Orthologs
Location:
7q21.3
Exon count:
17
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 7 NC_000007.14 (93424487..93574730, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (93053799..93204042, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene HEPACAM family member 2 Neighboring gene VPS50, EARP/GARPII complex subunit Neighboring gene microRNA 653 Neighboring gene microRNA 489 Neighboring gene uncharacterized LOC105375400 Neighboring gene ribosomal protein S27 pseudogene 17 Neighboring gene microRNA 4652

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Associated conditions

Description Tests
Osteoporosis
MedGen: C0029458 OMIM: 166710 GeneReviews: Not available
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NHGRI GWAS Catalog

Description
New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat and RANKL/M-CSF enhance osteoclast differentiation and activity by increasing osteoclast differentiation markers, such as cathepsin K and calcitonin receptor PubMed

Go to the HIV-1, Human Interaction Database

  • Calcitonin-like ligand receptors, organism-specific biosystem (from REACTOME)
    Calcitonin-like ligand receptors, organism-specific biosystemThe calcitonin peptide family comprises calcitonin, amylin, calcitonin gene-related peptide (CGRP), adrenomedullin (AM) and intermedin (AM2). Calcitonin is a 32 amino acid peptide, involved in bone h...
  • Class B/2 (Secretin family receptors), organism-specific biosystem (from REACTOME)
    Class B/2 (Secretin family receptors), organism-specific biosystemThis family is known as Family B (secretin-receptor family, family 2) G-protein-coupled receptors. Family B GPCRs include secretin, calcitonin, parathyroid hormone/parathyroid hormone-related peptide...
  • G alpha (s) signalling events, organism-specific biosystem (from REACTOME)
    G alpha (s) signalling events, organism-specific biosystemThe general function of the G alpha (s) subunit (Gs) is to activate adenylate cyclase, which in turn produces cAMP, leading to the activation of cAMP-dependent protein kinases (often referred to col...
  • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
    GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
  • GPCR ligand binding, organism-specific biosystem (from REACTOME)
    GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
  • GPCRs, Class B Secretin-like, organism-specific biosystem (from WikiPathways)
    GPCRs, Class B Secretin-like, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.cmbi.kun.nl/7tm/. The groupings are based on the GPCR phylogenetic tree available from the GPCRDB and the training sets used ...
  • Neuroactive ligand-receptor interaction, organism-specific biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, organism-specific biosystem
    Neuroactive ligand-receptor interaction
  • Neuroactive ligand-receptor interaction, conserved biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, conserved biosystem
    Neuroactive ligand-receptor interaction
  • Osteoclast differentiation, organism-specific biosystem (from KEGG)
    Osteoclast differentiation, organism-specific biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
  • Osteoclast differentiation, conserved biosystem (from KEGG)
    Osteoclast differentiation, conserved biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
  • RANKL/RANK Signaling Pathway, organism-specific biosystem (from WikiPathways)
    RANKL/RANK Signaling Pathway, organism-specific biosystemRANKL (Receptor activator of nuclear factor-kappa B ligand), RANK (Receptor activator of nuclear factor-kappa B) and the natural decoy receptor of RANKL, OPG (Osteoprotegerin) are three important mol...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcitonin binding IDA
Inferred from Direct Assay
more info
PubMed 
NOT calcitonin binding IDA
Inferred from Direct Assay
more info
PubMed 
calcitonin binding IPI
Inferred from Physical Interaction
more info
PubMed 
calcitonin receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
calcitonin receptor activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cell IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane NAS
Non-traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_013005.1 RefSeqGene

    Range
    5001..155244
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001164737.1NP_001158209.1  calcitonin receptor isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC003078, AK313996, L00587
    Consensus CDS
    CCDS55125.1
    UniProtKB/Swiss-Prot
    P30988
    UniProtKB/TrEMBL
    A0A0A0MRG0
    Related
    ENSP00000352561, ENST00000359558
    Conserved Domains (2) summary
    pfam00002
    Location:163421
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02793
    Location:87155
    HRM; Hormone receptor domain
  2. NM_001164738.1NP_001158210.1  calcitonin receptor isoform 2 precursor

    See identical proteins and their annotated locations for NP_001158210.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1. Variants 2 and 3 encode the same isoform (2).
    Source sequence(s)
    AB022178, AC003078
    Consensus CDS
    CCDS5631.1
    UniProtKB/Swiss-Prot
    P30988
    UniProtKB/TrEMBL
    A0A0C4DG16
    Related
    ENSP00000377959, OTTHUMP00000162535, ENST00000394441, OTTHUMT00000254661
    Conserved Domains (2) summary
    pfam00002
    Location:145387
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02793
    Location:69137
    HRM; Hormone receptor domain
  3. NM_001742.3NP_001733.1  calcitonin receptor isoform 2 precursor

    See identical proteins and their annotated locations for NP_001733.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1. Variants 2 and 3 encode the same isoform (2).
    Source sequence(s)
    AC003078, AC005024, AK313996
    Consensus CDS
    CCDS5631.1
    UniProtKB/Swiss-Prot
    P30988
    UniProtKB/TrEMBL
    A0A0C4DG16
    Related
    ENSP00000389295, OTTHUMP00000208686, ENST00000426151, OTTHUMT00000341744
    Conserved Domains (2) summary
    pfam00002
    Location:145387
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02793
    Location:69137
    HRM; Hormone receptor domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p2 Primary Assembly

    Range
    93424487..93574730 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018918.2 Alternate CHM1_1.1

    Range
    92983802..93134094 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)