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CCDC134 coiled-coil domain containing 134 [ Homo sapiens (human) ]

Gene ID: 79879, updated on 26-May-2016
Official Symbol
CCDC134provided by HGNC
Official Full Name
coiled-coil domain containing 134provided by HGNC
Primary source
HGNC:HGNC:26185
See related
Ensembl:ENSG00000100147 HPRD:07988; Vega:OTTHUMG00000151262
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Orthologs
Location:
22q13.2
Exon count:
8
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 22 NC_000022.11 (41800622..41832164)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (42196636..42228175)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene chromosome 22 open reading frame 46 Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene10 Neighboring gene meiotic double-stranded break formation protein 1 Neighboring gene sterol regulatory element binding transcription factor 2 Neighboring gene uncharacterized LOC105373045 Neighboring gene microRNA 33a

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide association study of CSF biomarkers Abeta1-42, t-tau, and p-tau181p in the ADNI cohort.
NHGRI GWA Catalog

Replication interactions

Interaction Pubs
Knockdown of coiled-coil domain containing 134 (CCDC134) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ22349, MGC21013

Gene Ontology Provided by GOA

Component Evidence Code Pubs
extracellular region IEA
Inferred from Electronic Annotation
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
coiled-coil domain-containing protein 134

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001304797.1NP_001291726.1  coiled-coil domain-containing protein 134 isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks three alternate exons, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AK299311, CB240942, HY013338
    Consensus CDS
    CCDS77680.1
    UniProtKB/TrEMBL
    B0QY51, B4DRL0
    Related
    ENSP00000385803, OTTHUMP00000199519, ENST00000402061, OTTHUMT00000321966
    Conserved Domains (1) summary
    pfam15002
    Location:3377
    ERK-JNK_inhib; ERK and JNK pathways, inhibitor
  2. NM_024821.3NP_079097.1  coiled-coil domain-containing protein 134 isoform 1 precursor

    See identical proteins and their annotated locations for NP_079097.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC017693, BX473493, CB240942, HY013338
    Consensus CDS
    CCDS33654.1
    UniProtKB/Swiss-Prot
    Q9H6E4
    Related
    ENSP00000255784, OTTHUMP00000199517, ENST00000255784, OTTHUMT00000321964
    Conserved Domains (1) summary
    pfam15002
    Location:23188
    ERK-JNK_inhib; ERK and JNK pathways, inhibitor

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p2 Primary Assembly

    Range
    41800622..41832164
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005261748.2XP_005261805.1  

    See identical proteins and their annotated locations for XP_005261805.1

    UniProtKB/Swiss-Prot
    Q9H6E4
    Conserved Domains (1) summary
    pfam15002
    Location:23188
    ERK-JNK_inhib; ERK and JNK pathways, inhibitor

Alternate CHM1_1.1

Genomic

  1. NC_018933.2 Alternate CHM1_1.1

    Range
    42156655..42182312
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)