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NEK11 NIMA related kinase 11 [ Homo sapiens (human) ]

Gene ID: 79858, updated on 8-May-2016
Official Symbol
NEK11provided by HGNC
Official Full Name
NIMA related kinase 11provided by HGNC
Primary source
HGNC:HGNC:18593
See related
Ensembl:ENSG00000114670 HPRD:14821; MIM:609779; Vega:OTTHUMG00000159654
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the never in mitosis gene A family of kinases. The encoded protein localizes to the nucleoli, and may function with NEK2A in the S-phase checkpoint. The encoded protein appears to play roles in DNA replication and response to genotoxic stress. Alternatively spliced transcript variants have been described.[provided by RefSeq, Mar 2009]
Orthologs
Location:
3q22.1
Exon count:
28
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 3 NC_000003.12 (131026850..131350465)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (130745694..131069309)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ATPase secretory pathway Ca2+ transporting 1 Neighboring gene cysteine and glycine rich protein 2 pseudogene Neighboring gene makorin ring finger protein 1 pseudogene Neighboring gene asteroid homolog 1 (Drosophila) Neighboring gene uncharacterized LOC339874 Neighboring gene nudix hydrolase 16 pseudogene 1 Neighboring gene nudix hydrolase 16

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ23495

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
G2 DNA damage checkpoint IMP
Inferred from Mutant Phenotype
more info
PubMed 
histone phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
intra-S DNA damage checkpoint IDA
Inferred from Direct Assay
more info
PubMed 
intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
mitotic cell cycle phase transition IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of mitotic cell cycle phase transition IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
Preferred Names
serine/threonine-protein kinase Nek11
Names
NIMA (never in mitosis gene a)- related kinase 11
NP_001139475.1
NP_079076.3
NP_665917.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029225.1 RefSeqGene

    Range
    5001..328616
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001146003.1NP_001139475.1  serine/threonine-protein kinase Nek11 isoform 3

    See identical proteins and their annotated locations for NP_001139475.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an exon in the 5' UTR and lacks an exon in the coding region, which results in a frameshift and an early stop codon compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AB071996, AK297300, AL833472, BX328072
    Consensus CDS
    CCDS54639.1
    UniProtKB/Swiss-Prot
    Q8NG66
    UniProtKB/TrEMBL
    B4DM56
    Related
    ENSP00000423458, OTTHUMP00000216140, ENST00000510688, OTTHUMT00000356758
    Conserved Domains (2) summary
    smart00220
    Location:29287
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd08222
    Location:28287
    STKc_Nek11; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 11
  2. NM_001321220.1NP_001308149.1  serine/threonine-protein kinase Nek11 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AB071996, AK027148, AK297300, AL833472, BX328072
    Conserved Domains (2) summary
    smart00220
    Location:29287
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd08222
    Location:28287
    STKc_Nek11; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 11
  3. NM_001321221.1NP_001308150.1  serine/threonine-protein kinase Nek11 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AB071996, AC116424, AK027148, AK297300, AL833472, BI032921, BX328072
    Conserved Domains (2) summary
    smart00220
    Location:29329
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd08222
    Location:28329
    STKc_Nek11; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 11
  4. NM_001321222.1NP_001308151.1  serine/threonine-protein kinase Nek11 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AB071996, AK027148, AK297300, AL833472, BX328072
    Conserved Domains (2) summary
    smart00220
    Location:29216
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:28216
    PKc_like; Protein Kinases, catalytic domain
  5. NM_001321223.1NP_001308152.1  serine/threonine-protein kinase Nek11 isoform 6

    Status: REVIEWED

    Source sequence(s)
    BC028587, DB446413
    Conserved Domains (2) summary
    smart00220
    Location:29287
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd08222
    Location:28287
    STKc_Nek11; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 11
  6. NM_001321224.1NP_001308153.1  serine/threonine-protein kinase Nek11 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AB071996, AK027148, AK293261, AK297300, AL833472
    Conserved Domains (2) summary
    smart00220
    Location:1139
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:1139
    PKc_like; Protein Kinases, catalytic domain
  7. NM_024800.4NP_079076.3  serine/threonine-protein kinase Nek11 isoform 1

    See identical proteins and their annotated locations for NP_079076.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform (1), also known as NEK11L.
    Source sequence(s)
    AB071996, AK297300, AL833472, BX328072
    Consensus CDS
    CCDS3069.1
    UniProtKB/Swiss-Prot
    Q8NG66
    UniProtKB/TrEMBL
    B4DM56
    Related
    ENSP00000372857, OTTHUMP00000216137, ENST00000383366, OTTHUMT00000356755
    Conserved Domains (2) summary
    smart00220
    Location:29287
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd08222
    Location:28287
    STKc_Nek11; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 11
  8. NM_145910.3NP_665917.1  serine/threonine-protein kinase Nek11 isoform 2

    See identical proteins and their annotated locations for NP_665917.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) includes an alternate exon, compared to variant 1, that causes a frameshift. The resulting protein (isoform 2), also known as NEK11S, is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AB071997, AK297300, BU674219
    Consensus CDS
    CCDS46915.1
    UniProtKB/Swiss-Prot
    Q8NG66
    UniProtKB/TrEMBL
    B4DM56
    Related
    ENSP00000425114, OTTHUMP00000216138, ENST00000511262, OTTHUMT00000356756
    Conserved Domains (2) summary
    smart00220
    Location:29287
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd08222
    Location:28287
    STKc_Nek11; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 11

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p2 Primary Assembly

    Range
    131026850..131350465
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005247783.2XP_005247840.1  

    UniProtKB/Swiss-Prot
    Q8NG66
    Related
    ENSP00000421851, OTTHUMP00000216604, ENST00000508196, OTTHUMT00000357517
    Conserved Domains (2) summary
    smart00220
    Location:29287
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd08222
    Location:28287
    STKc_Nek11; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 11
  2. XM_005247785.2XP_005247842.1  

    UniProtKB/TrEMBL
    E9PHI8
    Related
    ENSP00000421549, OTTHUMP00000216139, ENST00000510769, OTTHUMT00000356757
    Conserved Domains (2) summary
    smart00220
    Location:29216
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:28216
    PKc_like; Protein Kinases, catalytic domain
  3. XM_011513171.1XP_011511473.1  

    See identical proteins and their annotated locations for XP_011511473.1

    UniProtKB/Swiss-Prot
    Q8NG66
    Conserved Domains (2) summary
    smart00220
    Location:29287
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd08222
    Location:28287
    STKc_Nek11; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 11
  4. XM_011513170.1XP_011511472.1  

    Conserved Domains (2) summary
    smart00220
    Location:29287
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd08222
    Location:28287
    STKc_Nek11; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 11
  5. XM_011513172.1XP_011511474.1  

    See identical proteins and their annotated locations for XP_011511474.1

    UniProtKB/TrEMBL
    E9PHI8
    Conserved Domains (2) summary
    smart00220
    Location:29216
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:28216
    PKc_like; Protein Kinases, catalytic domain
  6. XM_011513180.1XP_011511482.1  

    Conserved Domains (2) summary
    smart00220
    Location:29287
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd08222
    Location:28287
    STKc_Nek11; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 11
  7. XM_011513179.1XP_011511481.1  

    UniProtKB/Swiss-Prot
    Q8NG66
    Related
    ENSP00000426662, OTTHUMP00000216112, ENST00000507910, OTTHUMT00000356706
    Conserved Domains (2) summary
    smart00220
    Location:29287
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd08222
    Location:28287
    STKc_Nek11; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 11
  8. XM_011513178.1XP_011511480.1  

    Conserved Domains (2) summary
    smart00220
    Location:29287
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd08222
    Location:28287
    STKc_Nek11; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 11
  9. XM_011513168.1XP_011511470.1  

    See identical proteins and their annotated locations for XP_011511470.1

    UniProtKB/Swiss-Prot
    Q8NG66
    Conserved Domains (2) summary
    smart00220
    Location:29287
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd08222
    Location:28287
    STKc_Nek11; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 11
  10. XM_011513173.1XP_011511475.1  

    See identical proteins and their annotated locations for XP_011511475.1

    Conserved Domains (2) summary
    smart00220
    Location:1139
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:1139
    PKc_like; Protein Kinases, catalytic domain
  11. XM_011513182.1XP_011511484.1  

    UniProtKB/TrEMBL
    B4DDN2
    Conserved Domains (2) summary
    smart00220
    Location:1139
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:1139
    PKc_like; Protein Kinases, catalytic domain
  12. XM_011513165.1XP_011511467.1  

    See identical proteins and their annotated locations for XP_011511467.1

    UniProtKB/Swiss-Prot
    Q8NG66
    Conserved Domains (2) summary
    smart00220
    Location:29287
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd08222
    Location:28287
    STKc_Nek11; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 11
  13. XM_011513167.1XP_011511469.1  

    See identical proteins and their annotated locations for XP_011511469.1

    UniProtKB/Swiss-Prot
    Q8NG66
    Conserved Domains (2) summary
    smart00220
    Location:29287
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd08222
    Location:28287
    STKc_Nek11; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 11
  14. XM_011513169.1XP_011511471.1  

    See identical proteins and their annotated locations for XP_011511471.1

    UniProtKB/Swiss-Prot
    Q8NG66
    Conserved Domains (2) summary
    smart00220
    Location:29287
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd08222
    Location:28287
    STKc_Nek11; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 11
  15. XM_011513166.1XP_011511468.1  

    See identical proteins and their annotated locations for XP_011511468.1

    UniProtKB/Swiss-Prot
    Q8NG66
    Conserved Domains (2) summary
    smart00220
    Location:29287
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd08222
    Location:28287
    STKc_Nek11; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 11
  16. XM_011513174.1XP_011511476.1  

    See identical proteins and their annotated locations for XP_011511476.1

    Conserved Domains (2) summary
    smart00220
    Location:1139
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:1139
    PKc_like; Protein Kinases, catalytic domain
  17. XM_011513176.1XP_011511478.1  

    See identical proteins and their annotated locations for XP_011511478.1

    Conserved Domains (2) summary
    smart00220
    Location:1139
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:1139
    PKc_like; Protein Kinases, catalytic domain
  18. XM_011513175.1XP_011511477.1  

    See identical proteins and their annotated locations for XP_011511477.1

    Conserved Domains (2) summary
    smart00220
    Location:1139
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:1139
    PKc_like; Protein Kinases, catalytic domain
  19. XM_011513177.1XP_011511479.1  

    See identical proteins and their annotated locations for XP_011511479.1

    Conserved Domains (2) summary
    smart00220
    Location:1139
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:1139
    PKc_like; Protein Kinases, catalytic domain
  20. XM_006713749.2XP_006713812.1  

  21. XM_011513181.1XP_011511483.1  

    Conserved Domains (1) summary
    cl21453
    Location:1105
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. XR_924179.1 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018914.2 Alternate CHM1_1.1

    Range
    130709218..131032898
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)