LIN28A lin-28 homolog A (C. elegans) [Homo sapiens (human)] - Gene

Summary

Go to the top of the page Help

Official Symbol: LIN28Aprovided by HGNC
Official Full Name: lin-28 homolog A (C. elegans)provided by HGNC
Primary source: HGNC:15986
See related: Ensembl:ENSG00000131914; HPRD:17278; MIM:611043; Vega:OTTHUMG00000003550
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CSDD1; LIN28; LIN-28; ZCCHC1; lin-28A

Genomic context

Go to the top of the page Help

Location :: 1p36.11

Sequence :: Chromosome: 1; NC_000001.10 (26737269..26756219)

See LIN28A in Epigenomics, MapViewer

Chromosome 1 - NC_000001.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions What's a GeneRIF?

LIN28A immunohistochemistry as a highly sensitive and specific, rapid, inexpensive diagnostic tool for routine pathological verification of embryonal tumor with multilayered rosettes.
Title: LIN28A immunoreactivity is a potent diagnostic marker of embryonal tumor with multilayered rosettes (ETMR).
Lin28a is an appropriate cancer stem cell target molecule for oral squamous cell carcinoma treatment.
Title: Lin28a is a putative factor in regulating cancer stem cell-like properties in side population cells of oral squamous cell carcinoma.
that LIN28 was a negative independent predictor for both overall survival and recurrence-free survival in hepatocellular carcinoma patients who met the Milan criteria. LIN28 was expressed at a higher frequency in tumor tissues than in non-HCC tissues.
Title: LIN28 expression and prognostic value in hepatocellular carcinoma patients who meet the Milan criteria and undergo hepatectomy.
These findings identify important regulatory functions of LIN28 via direct mRNA interactions.
Title: LIN28 binds messenger RNAs at GGAGA motifs and regulates splicing factor abundance.
Overexpression of Lin28 in breast cancer cells considerably induced p21 and Rb expression and inhibited Let-7 miRNA levels.
Title: Lin28 mediates paclitaxel resistance by modulating p21, Rb and Let-7a miRNA in breast cancer cells.
A subset of Lin28 mRNA targets are destabilized in a Drosha-dependent manner.
Title: Drosha mediates destabilization of Lin28 mRNA targets.
LIN28 is expressed only in a very small subpopulation of spermatogonia in the adult monkey and human testis
Title: The pluripotency factor LIN28 in monkey and human testes: a marker for spermatogonial stem cells?
LIN28 expression is germ cell specific and becomes restricted to a subpopulation of germ cells with increasing gestation in the fetal ovary.
Title: LIN28 is selectively expressed by primordial and pre-meiotic germ cells in the human fetal ovary.
show that MLL fusion proteins negatively regulate production of miR-150, an miRNA widely repressed in acute leukemia, by blocking miR-150 precursors from being processed to mature miRNAs through MYC/LIN28 functional axis
Title: Blockade of miR-150 maturation by MLL-fusion/MYC/LIN-28 is required for MLL-associated leukemia.
Lin28 uses two different TUTases to control let-7 expression.
Title: Lin28-mediated control of let-7 microRNA expression by alternative TUTases Zcchc11 (TUT4) and Zcchc6 (TUT7).

Submit: New GeneRIF Correction See all (44)

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

NHGRI GWAS Catalog

Hundreds of variants clustered in genomic loci and biological pathways affect human height.

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description
BioGRID:122842	BioGRID:124082	DOT1L		BioGRID	PubMed	Phenotypic Suppression
BioGRID:122842	BioGRID:113370	ZFP36		BioGRID	PubMed	Affinity Capture-RNA

Pathways from BioSystems

Go to the top of the page Help

Cardiac Progenitor Differentiation, organism-specific biosystem (from WikiPathways)
Cardiac Progenitor Differentiation, organism-specific biosystemFactors involved in the induction of cardiac differentiation in vitro and in vivo. This model was based on the below two review articles.

General gene information

Go to the top of the page Help

Markers

Z94399 (e-PCR)
- UniSTS:43808

D8S2279 (e-PCR)
- UniSTS:473907

D10S16 (e-PCR)
- UniSTS:155756

D13S1553 (e-PCR)
- UniSTS:473482

D11S3114 (e-PCR)
- UniSTS:152207

RH66756 (e-PCR)
- UniSTS:89576

D11S1085 (e-PCR)
- UniSTS:4587

Homology

Homologs of the LIN28A gene: The LIN28A gene is conserved in chimpanzee, dog, cow, mouse, rat, chicken, and zebrafish.
Map Viewer (Mouse, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
DNA binding	IEA Inferred from Electronic Annotation more info
RNA binding	IDA Inferred from Direct Assay more info	PubMed
mRNA binding	IEA Inferred from Electronic Annotation more info
miRNA binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
translation initiation factor binding	IEA Inferred from Electronic Annotation more info
zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
RNA 3'-end processing	IMP Inferred from Mutant Phenotype more info	PubMed
germ cell development	IEA Inferred from Electronic Annotation more info
miRNA catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of glial cell differentiation	IEA Inferred from Electronic Annotation more info
positive regulation of neuron differentiation	IEA Inferred from Electronic Annotation more info
positive regulation of translation	IEA Inferred from Electronic Annotation more info
pre-miRNA processing	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of gene silencing by miRNA	IEA Inferred from Electronic Annotation more info
regulation of transcription, DNA-dependent	IEA Inferred from Electronic Annotation more info
stem cell maintenance	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
cytoplasmic mRNA processing body	IDA Inferred from Direct Assay more info	PubMed
cytoplasmic stress granule	IDA Inferred from Direct Assay more info	PubMed
nucleolus	IEA Inferred from Electronic Annotation more info
nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: protein lin-28 homolog A

Names: protein lin-28 homolog A; RNA-binding protein LIN-28; zinc finger, CCHC domain containing 1; zinc finger CCHC domain-containing protein 1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_024674.4 → NP_078950.1 protein lin-28 homolog A

Status: VALIDATED

Source sequence(s)

AL513365, BC028566

Consensus CDS

CCDS280.1

UniProtKB/Swiss-Prot

Q9H9Z2

Related

ENSP00000363314, OTTHUMP00000003663, ENST00000326279, OTTHUMT00000009891

Conserved Domains (1) summary

cd04458
Location:42 – 111
Blast Score: 170

CSP_CDS; Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein. ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p10 Primary Assembly

Genomic

NC_000001.10 Reference GRCh37.p10 Primary Assembly

Range

26737269..26756219

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000133.1 Alternate HuRef

Range

24991870..25010565

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.0

Genomic

NC_018912.1 Alternate CHM1_1.0

Range

26953852..26972802

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	ABBA01034908.1 (14177..28793)	None
genomic	ABBA01034909.1	None
genomic	ABBA01034910.1	None
genomic	AL513365.27 (84615..103565)	None
genomic	AMYH01000401.1 (4768..23718)	None
genomic	CH471059.2	EAX07814.1
		EAX07815.1
mRNA	AF521099.1	AAM77751.1
mRNA	AK022519.1	BAB14075.1
mRNA	BC028566.2	AAH28566.1
other-genetic	DQ893398.2	ABM84324.1
other-genetic	DQ896719.2	ABM87718.1