Display Settings:

Format

Send to:

Choose Destination

LIN28A lin-28 homolog A (C. elegans) [ Homo sapiens (human) ]

Gene ID: 79727, updated on 27-Sep-2014
Official Symbol
LIN28Aprovided by HGNC
Official Full Name
lin-28 homolog A (C. elegans)provided by HGNC
Primary source
HGNC:HGNC:15986
See related
Ensembl:ENSG00000131914; HPRD:17278; MIM:611043; Vega:OTTHUMG00000003550
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CSDD1; LIN28; LIN-28; ZCCHC1; lin-28A
See LIN28A in Epigenomics, MapViewer
Location:
1p36.11
Exon count:
5
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 1 NC_000001.11 (26410778..26429728)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (26737269..26756219)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene absent in melanoma 1-like Neighboring gene ribosomal protein L34 pseudogene 4 Neighboring gene zinc finger protein 683 Neighboring gene dehydrodolichyl diphosphate synthase Neighboring gene uncharacterized LOC101928324 Neighboring gene ribosomal protein L17 pseudogene 9

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
NHGRI GWA Catalog
  • Cardiac Progenitor Differentiation, organism-specific biosystem (from WikiPathways)
    Cardiac Progenitor Differentiation, organism-specific biosystemFactors involved in the induction of cardiac differentiation in vitro and in vivo. This model was based on the below two review articles.
  • Developmental Biology, organism-specific biosystem (from REACTOME)
    Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
  • Transcriptional regulation of pluripotent stem cells, organism-specific biosystem (from REACTOME)
    Transcriptional regulation of pluripotent stem cells, organism-specific biosystemPluripotent stem cells are undifferentiated cells posessing an abbreviated cell cycle (reviewed in Stein et al. 2012), a characteristic profile of gene expression (Rao et al. 2004, Kim et al. 2006, P...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ12457

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
mRNA binding IEA
Inferred from Electronic Annotation
more info
 
miRNA binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
translation initiation factor binding IEA
Inferred from Electronic Annotation
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
RNA 3'-end processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
germ cell development IEA
Inferred from Electronic Annotation
more info
 
miRNA catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of glial cell differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of translation IEA
Inferred from Electronic Annotation
more info
 
pre-miRNA processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of gene silencing by miRNA IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
stem cell maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic mRNA processing body IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic stress granule IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus IEA
Inferred from Electronic Annotation
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
protein lin-28 homolog A
Names
protein lin-28 homolog A
RNA-binding protein LIN-28
zinc finger, CCHC domain containing 1
zinc finger CCHC domain-containing protein 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024674.4NP_078950.1  protein lin-28 homolog A

    See proteins identical to NP_078950.1

    Status: VALIDATED

    Source sequence(s)
    AL513365, BC028566
    Consensus CDS
    CCDS280.1
    UniProtKB/Swiss-Prot
    Q9H9Z2
    Related
    ENSP00000363314, OTTHUMP00000003663, ENST00000326279, OTTHUMT00000009891
    Conserved Domains (1) summary
    cd04458
    Location:42111
    CSP_CDS; Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000001.11 

    Range
    26410778..26429728
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006710900.1XP_006710963.1  

    See proteins identical to XP_006710963.1

    UniProtKB/Swiss-Prot
    Q9H9Z2
    Conserved Domains (1) summary
    cd04458
    Location:42111
    CSP_CDS; Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box ...
  2. XM_006710899.1XP_006710962.1  

    See proteins identical to XP_006710962.1

    UniProtKB/Swiss-Prot
    Q9H9Z2
    Related
    ENSP00000254231, ENST00000254231
    Conserved Domains (1) summary
    cd04458
    Location:42111
    CSP_CDS; Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box ...

Alternate HuRef

Genomic

  1. AC_000133.1 

    Range
    24991870..25010565
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018912.2 

    Range
    26850273..26869222
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)