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HSPBAP1 HSPB1 associated protein 1 [ Homo sapiens (human) ]

Gene ID: 79663, updated on 8-May-2016
Official Symbol
HSPBAP1provided by HGNC
Official Full Name
HSPB1 associated protein 1provided by HGNC
Primary source
HGNC:HGNC:16389
See related
Ensembl:ENSG00000169087 HPRD:12197; MIM:608263; Vega:OTTHUMG00000159550
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PASS1
Summary
This gene encodes a protein that binds to one of the small heat shock proteins, specifically hsp27. Hsp27 is involved with cell growth and differentiation. This encoded protein was found to be abnormally expressed in patients with intractable epilepsy, although how brain function is affected remains unknown. [provided by RefSeq, Sep 2011]
Orthologs
Location:
3q21.1
Exon count:
13
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 3 NC_000003.12 (122739997..122795216, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (122458844..122512666, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 4B pseudogene 8 Neighboring gene poly(ADP-ribose) polymerase family member 14 Neighboring gene disrupted in renal carcinoma 2 Neighboring gene uncharacterized LOC100129550 Neighboring gene semaphorin 5B Neighboring gene uncharacterized LOC105374072

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ22623, FLJ39386

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
HSPB1-associated protein 1
Names
27 kDa heat shock protein-associated protein 1
HSPB (heat shock 27kDa) associated protein 1
protein associating with small stress protein PASS1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_030032.1 RefSeqGene

    Range
    5001..58823
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001320728.1NP_001307657.1  HSPB1-associated protein 1 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the 3' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AF400663, BC011897, BU630355, HY020808
    UniProtKB/Swiss-Prot
    Q96EW2
    Conserved Domains (1) summary
    cl22893
    Location:37246
    JmjC; JmjC domain, hydroxylase
  2. NM_024610.5NP_078886.2  HSPB1-associated protein 1 isoform 1

    See identical proteins and their annotated locations for NP_078886.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK289410, BC011897, BI912690, BU630355
    Consensus CDS
    CCDS3017.1
    UniProtKB/Swiss-Prot
    Q96EW2
    UniProtKB/TrEMBL
    A8K045
    Related
    ENSP00000302562, OTTHUMP00000215800, ENST00000306103, OTTHUMT00000356161
    Conserved Domains (1) summary
    pfam13621
    Location:37272
    Cupin_8; Cupin-like domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p2 Primary Assembly

    Range
    122739997..122795216 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011513130.1XP_011511432.1  

    See identical proteins and their annotated locations for XP_011511432.1

    Conserved Domains (1) summary
    pfam13621
    Location:2235
    Cupin_8; Cupin-like domain
  2. XM_011513132.1XP_011511434.1  

    See identical proteins and their annotated locations for XP_011511434.1

    UniProtKB/TrEMBL
    Q9H641
  3. XM_011513129.1XP_011511431.1  

    Conserved Domains (1) summary
    cl22893
    Location:108317
    JmjC; JmjC domain, hydroxylase
  4. XM_011513128.1XP_011511430.1  

    Conserved Domains (1) summary
    pfam13621
    Location:108343
    Cupin_8; Cupin-like domain
  5. XM_005247762.1XP_005247819.1  

    UniProtKB/Swiss-Prot
    Q96EW2
    Conserved Domains (1) summary
    cl22893
    Location:37249
    JmjC; JmjC domain, hydroxylase
  6. XM_011513131.1XP_011511433.1  

    See identical proteins and their annotated locations for XP_011511433.1

    UniProtKB/Swiss-Prot
    Q96EW2
    Conserved Domains (1) summary
    cl22893
    Location:37190
    JmjC; JmjC domain, hydroxylase

Alternate CHM1_1.1

Genomic

  1. NC_018914.2 Alternate CHM1_1.1

    Range
    122422413..122476340 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)