Display Settings:

Format

Send to:

Choose Destination

AIMP2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 [ Homo sapiens (human) ]

Gene ID: 7965, updated on 25-Jul-2014
Official Symbol
AIMP2provided by HGNC
Official Full Name
aminoacyl tRNA synthetase complex-interacting multifunctional protein 2provided by HGNC
Primary source
HGNC:20609
Locus tag
PRO0992
See related
Ensembl:ENSG00000106305; HPRD:02915; MIM:600859; Vega:OTTHUMG00000122077
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P38; JTV1; JTV-1; PRO0992
Summary
The JTV1 gene is located on chromosome 7p22 flanked by two genes, HRI and PMS2. JTV1 and HRI overlap slightly and are arranged in a tail-to-tail fashion. JTV1 and PMS2 are separated by approximately 200 base pairs and are arranged head-to-head. JTV1 is transcribed in the opposite direction compared to HRI and PMS2. The function of the JTV1 gene product is unknown. [provided by RefSeq, Jul 2008]
See AIMP2 in Epigenomics, MapViewer
Location:
7p22
Exon count:
7
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 7 NC_000007.14 (6009251..6023834)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (6048882..6063465)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene radial spoke head 10 homolog B (Chlamydomonas) Neighboring gene PMS2 postmeiotic segregation increased 2 (S. cerevisiae) Neighboring gene eukaryotic translation initiation factor 2-alpha kinase 1 Neighboring gene ankyrin repeat domain 61 Neighboring gene ubiquitin specific peptidase 42

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
matrix gag HIV-1 MA is identified to have a physical interaction with aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 (AIMP2) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Protein Interaction Database

  • Cytosolic tRNA aminoacylation, organism-specific biosystem (from REACTOME)
    Cytosolic tRNA aminoacylation, organism-specific biosystemCytosolic tRNA synthetases catalyze the reactions of tRNAs encoded in the nuclear genome, their cognate amino acids, and ATP to form aminoacyl-tRNAs, AMP, and pyrophosphate. Eight of the tRNA synthet...
  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Keap1-Nrf2 Pathway, organism-specific biosystem (from WikiPathways)
    Keap1-Nrf2 Pathway, organism-specific biosystemBased on [http://www.nature.com/nrc/journal/v3/n10/fig_tab/nrc1189_F4.html Surh, 2003, figure 4].
  • Osteoclast Signaling, organism-specific biosystem (from WikiPathways)
    Osteoclast Signaling, organism-specific biosystem
    Osteoclast Signaling
  • tRNA Aminoacylation, organism-specific biosystem (from REACTOME)
    tRNA Aminoacylation, organism-specific biosystemtRNA synthetases catalyze the ligation of tRNAs to their cognate amino acids in an ATP-dependent manner. The reaction proceeds in two steps. First, amino acid and ATP form an aminoacyl adenylate mole...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Type II pneumocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
gene expression TAS
Traceable Author Statement
more info
 
negative regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
tRNA aminoacylation for protein translation TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
aminoacyl tRNA synthase complex-interacting multifunctional protein 2
Names
aminoacyl tRNA synthase complex-interacting multifunctional protein 2
protein JTV-1
ARS-interacting multi-functional protein 2
multisynthase complex auxiliary component p38
multisynthetase complex auxiliary component p38

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006303.3NP_006294.2  aminoacyl tRNA synthase complex-interacting multifunctional protein 2

    See proteins identical to NP_006294.2

    Status: VALIDATED

    Source sequence(s)
    AC005995, BC002853
    Consensus CDS
    CCDS5344.1
    UniProtKB/Swiss-Prot
    Q13155
    Related
    ENSP00000223029, OTTHUMP00000151158, ENST00000223029, OTTHUMT00000242834
    Conserved Domains (1) summary
    cd03200
    Location:214309
    Blast Score: 443
    GST_C_AIMP2; Glutathione S-transferase C-terminal-like, alpha helical domain of Aminoacyl tRNA synthetase complex-Interacting Multifunctional Protein 2

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000007.14 

    Range
    6009251..6023834
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005249848.1XP_005249905.1  

    Conserved Domains (1) summary
    cd03200
    Location:174269
    Blast Score: 438
    GST_C_AIMP2; Glutathione S-transferase C-terminal-like, alpha helical domain of Aminoacyl tRNA synthetase complex-Interacting Multifunctional Protein 2
  2. XM_006715772.1XP_006715835.1  

    Conserved Domains (1) summary
    cd03200
    Location:170265
    Blast Score: 436
    GST_C_AIMP2; Glutathione S-transferase C-terminal-like, alpha helical domain of Aminoacyl tRNA synthetase complex-Interacting Multifunctional Protein 2
  3. XM_005249850.1XP_005249907.1  

    UniProtKB/TrEMBL
    A8MU58
    Conserved Domains (1) summary
    cd03200
    Location:136231
    Blast Score: 438
    GST_C_AIMP2; Glutathione S-transferase C-terminal-like, alpha helical domain of Aminoacyl tRNA synthetase complex-Interacting Multifunctional Protein 2
  4. XM_005249847.1XP_005249904.1  

    Conserved Domains (1) summary
    cd03200
    Location:207302
    Blast Score: 439
    GST_C_AIMP2; Glutathione S-transferase C-terminal-like, alpha helical domain of Aminoacyl tRNA synthetase complex-Interacting Multifunctional Protein 2

Alternate HuRef

Genomic

  1. AC_000139.1 

    Range
    5920617..5935248
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018918.2 

    Range
    6048601..6063172
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)