AIMP2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 [Homo sapiens (human)] - Gene

Summary

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Official Symbol: AIMP2provided by HGNC
Official Full Name: aminoacyl tRNA synthetase complex-interacting multifunctional protein 2provided by HGNC
Primary source: HGNC:20609
Locus tag: PRO0992
See related: Ensembl:ENSG00000106305; HPRD:02915; MIM:600859; Vega:OTTHUMG00000122077
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: P38; JTV1; JTV-1; PRO0992
Summary: The JTV1 gene is located on chromosome 7p22 flanked by two genes, HRI and PMS2. JTV1 and HRI overlap slightly and are arranged in a tail-to-tail fashion. JTV1 and PMS2 are separated by approximately 200 base pairs and are arranged head-to-head. JTV1 is transcribed in the opposite direction compared to HRI and PMS2. The function of the JTV1 gene product is unknown. [provided by RefSeq, Jul 2008]

Genomic context

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Location :: 7p22

Sequence :: Chromosome: 7; NC_000007.13 (6048882..6063465)

See AIMP2 in Epigenomics, MapViewer

Chromosome 7 - NC_000007.13 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

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Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

AIMP2-DX2, a splicing variant of tumor suppressor AIMP2, can be a therapeutic target to control chemoresistant epithelial ovarian cancer .
Title: Splicing variant of AIMP2 as an effective target against chemoresistant ovarian cancer.
downregulation of AIMP2 lacking exon 2 (AIMP2-DX2), expressed in different cancer cells, suppressed the epidermal growth factor receptor/mitogen activated protein kinase signaling pathway
Title: Lentiviral vector-mediated shRNA against AIMP2-DX2 suppresses lung cancer cell growth through blocking glucose uptake.
ribozyme could selectively deliver the activity of a suicide gene into the AIMP2-DX2 RNA expressing lung cancer cells and thereby specifically and effectively retard the growth of the cancer cells with prodrug treatment.
Title: Selective regression of cancer cells expressing a splicing variant of AIMP2 through targeted RNA replacement by trans-splicing ribozyme.
a splicing variant of AIMP2 lacking exon 2 (AIMP2-DX2) is highly expressed by alternative splicing in human lung cancer cells and patient's tissues
Title: Cancer-associated splicing variant of tumor suppressor AIMP2/p38: pathological implication in tumorigenesis.
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China.
Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic susceptibility to distinct bladder cancer subphenotypes.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

HIV-1 protein interactions

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Protein	Gene	Interaction	Pubs
matrix	gag	HIV-1 MA is identified to have a physical interaction with aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 (AIMP2) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses	PubMed

Go to the HIV-1, Human Protein Interaction Database

Interactions

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_006294.2	NP_004437.1	EPRS	BIND	PubMed	p38 interacts with GluProRS.
NP_006294.2	NP_005539.1	KARS	BIND	PubMed	p38 interacts with LysRS.
Q13155	Q12904	AIMP1	HPRD	PubMed
Q13155	Q13155	AIMP2	HPRD	PubMed
Q13155	Chromosome 19 open reading frame 57	C19orf57	HPRD	PubMed
Q13155	P14868	DARS	HPRD	PubMed
Q13155	P07814	EPRS	HPRD	PubMed
Q13155	Q12929	EPS8	HPRD	PubMed
Q13155	Q13643	FHL3	HPRD	PubMed
Q13155	Q96AE4	FUBP1	HPRD	PubMed
Q13155	Q15046	KARS	HPRD	PubMed
Q13155	Q8TAP4	LMO3	HPRD	PubMed
Q13155	Q8TBB1	LNX1	HPRD	PubMed
Q13155	O60260	PARK2	HPRD	PubMed
BioGRID:113684	BioGRID:106575	ACTB	BioGRID	PubMed	Two-hybrid
BioGRID:113684	BioGRID:114679	AIMP1	BioGRID	PubMed	Affinity Capture-MS; Co-fractionation
BioGRID:113684	BioGRID:113684	AIMP2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:113684	BioGRID:106848	APP	BioGRID	PubMed	Reconstituted Complex
BioGRID:113684	BioGRID:106826	BIRC2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:113684	BioGRID:120611	BLOC1S4	BioGRID	PubMed	Two-hybrid
BioGRID:113684	BioGRID:122590	C19orf57	BioGRID	PubMed	Affinity Capture-Western; Two-hybrid
BioGRID:113684	BioGRID:570479	CEP170P1	BioGRID	PubMed	Two-hybrid
BioGRID:113684	BioGRID:107532	CHD3	BioGRID	PubMed	Two-hybrid
BioGRID:113684	BioGRID:107984	DARS	BioGRID	PubMed	Affinity Capture-MS; Co-fractionation; Two-hybrid
BioGRID:113684	BioGRID:120459	DARS2	BioGRID	PubMed	Two-hybrid
BioGRID:113684	BioGRID:115777	DEAF1	BioGRID	PubMed	Two-hybrid
BioGRID:113684	BioGRID:123045	DSN1	BioGRID	PubMed	Two-hybrid
BioGRID:113684	BioGRID:114898	EEF1E1	BioGRID	PubMed	Affinity Capture-MS; Co-fractionation
BioGRID:113684	BioGRID:108296	EIF4G1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:113684	BioGRID:108372	EPRS	BioGRID	PubMed	Co-fractionation
BioGRID:113684	BioGRID:108373	EPS8	BioGRID	PubMed	Two-hybrid
BioGRID:113684	BioGRID:108535	FGB	BioGRID	PubMed	Two-hybrid
BioGRID:113684	BioGRID:108566	FHL3	BioGRID	PubMed	Two-hybrid
BioGRID:113684	BioGRID:108621	FN1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:113684	BioGRID:114399	FUBP1	BioGRID	PubMed	Two-hybrid
BioGRID:113684	BioGRID:109420	HNRNPA1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:113684	BioGRID:109540	HSPA4	BioGRID	PubMed	Affinity Capture-Western
BioGRID:113684	BioGRID:109605	IARS	BioGRID	PubMed	Affinity Capture-MS; Co-fractionation; Two-hybrid
BioGRID:113684	BioGRID:114353	IQGAP1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:113684	BioGRID:109938	KARS	BioGRID	PubMed	Co-fractionation; Two-hybrid
BioGRID:113684	BioGRID:109992	KDR	BioGRID	PubMed	Two-hybrid
BioGRID:113684	BioGRID:115114	KIAA0101	BioGRID	PubMed	Affinity Capture-MS
BioGRID:113684	BioGRID:116955	KIAA0947	BioGRID	PubMed	Two-hybrid
BioGRID:113684	BioGRID:121617	KIAA1377	BioGRID	PubMed	Two-hybrid
BioGRID:113684	BioGRID:121775	KIAA1967	BioGRID	PubMed	Affinity Capture-MS
BioGRID:113684	BioGRID:122313	KLC2	BioGRID	PubMed	Two-hybrid
BioGRID:113684	BioGRID:119584	LARS	BioGRID	PubMed	Co-fractionation
BioGRID:113684	BioGRID:120977	LMO3	BioGRID	PubMed	Two-hybrid
BioGRID:113684	BioGRID:124219	LNX1	BioGRID	PubMed	Two-hybrid
BioGRID:113684	BioGRID:119646	LUC7L2	BioGRID	PubMed	Two-hybrid
BioGRID:113684	BioGRID:110311	MARS	BioGRID	PubMed	Affinity Capture-MS; Co-fractionation
BioGRID:113684	BioGRID:115126	MATR3	BioGRID	PubMed	Two-hybrid
BioGRID:113684	BioGRID:116865	MCF2L	BioGRID	PubMed	Two-hybrid
BioGRID:113684	BioGRID:117956	NGFRAP1	BioGRID	PubMed	Two-hybrid
BioGRID:113684	BioGRID:111105	PARK2	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:113684	BioGRID:111510	PPP2R1A	BioGRID	PubMed	Two-hybrid
BioGRID:113684	BioGRID:111679	PSMC6	BioGRID	PubMed	Affinity Capture-MS
BioGRID:113684	BioGRID:111692	PSME1	BioGRID	PubMed	Two-hybrid
BioGRID:113684	BioGRID:111697	PTBP1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:113684	BioGRID:111797	QARS	BioGRID	PubMed	Affinity Capture-MS; Co-fractionation; Two-hybrid
BioGRID:113684	BioGRID:111852	RARS	BioGRID	PubMed	Affinity Capture-MS; Co-fractionation; Two-hybrid
BioGRID:113684	BioGRID:112076	RPL27A	BioGRID	PubMed	Affinity Capture-MS
BioGRID:113684	BioGRID:115563	STUB1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:113684	BioGRID:113188	SUMO1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:113684	BioGRID:115328	TANK	BioGRID	PubMed	Two-hybrid
BioGRID:113684	BioGRID:119942	TERF2IP	BioGRID	PubMed	Two-hybrid
BioGRID:113684	BioGRID:113010	TP53	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:113684	BioGRID:113038	TRAF2	BioGRID	PubMed	Affinity Capture-Western; Two-hybrid
BioGRID:113684	BioGRID:117968	TRMT2A	BioGRID	PubMed	Two-hybrid
BioGRID:113684	BioGRID:113165	UBA1	BioGRID	PubMed	Co-fractionation
BioGRID:113684	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:113684	BioGRID:123141	ZC3H12A	BioGRID	PubMed	Two-hybrid
BioGRID:113684	BioGRID:1205537	gag	BioGRID	PubMed	Affinity Capture-MS

Pathways from BioSystems

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Cytosolic tRNA aminoacylation, organism-specific biosystem (from REACTOME)
Cytosolic tRNA aminoacylation, organism-specific biosystemCytosolic tRNA synthetases catalyze the reactions of tRNAs encoded in the nuclear genome, their cognate amino acids, and ATP to form aminoacyl-tRNAs, AMP, and pyrophosphate. Eight of the tRNA synthet...
Gene Expression, organism-specific biosystem (from REACTOME)
Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
Keap1-Nrf2 Pathway, organism-specific biosystem (from WikiPathways)
Keap1-Nrf2 Pathway, organism-specific biosystemBased on [http://www.nature.com/nrc/journal/v3/n10/fig_tab/nrc1189_F4.html Surh, 2003, figure 4].
Osteoclast Signaling, organism-specific biosystem (from WikiPathways)
Osteoclast Signaling, organism-specific biosystem
Osteoclast Signaling
tRNA Aminoacylation, organism-specific biosystem (from REACTOME)
tRNA Aminoacylation, organism-specific biosystemtRNA synthetases catalyze the ligation of tRNAs to their cognate amino acids in an ATP-dependent manner. The reaction proceeds in two steps. First, amino acid and ATP form an aminoacyl adenylate mole...

General gene information

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Markers

G54017 (e-PCR)
- UniSTS:109399

SHGC-37403 (e-PCR)
- UniSTS:1951

RH12212 (e-PCR)
- UniSTS:52950

D7S2761 (e-PCR)
- UniSTS:25571

Homology

Homologs of the AIMP2 gene: The AIMP2 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, and zebrafish.
Map Viewer (Mouse, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
Type II pneumocyte differentiation	IEA Inferred from Electronic Annotation more info
apoptotic process	IEA Inferred from Electronic Annotation more info
gene expression	TAS Traceable Author Statement more info
negative regulation of cell proliferation	IEA Inferred from Electronic Annotation more info
positive regulation of protein ubiquitination	IEA Inferred from Electronic Annotation more info
tRNA aminoacylation for protein translation	TAS Traceable Author Statement more info

Component	Evidence Code	Pubs
cytosol	TAS Traceable Author Statement more info
nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: aminoacyl tRNA synthase complex-interacting multifunctional protein 2

Names: aminoacyl tRNA synthase complex-interacting multifunctional protein 2; protein JTV-1; ARS-interacting multi-functional protein 2; multisynthase complex auxiliary component p38; multisynthetase complex auxiliary component p38

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_006303.3 → NP_006294.2 aminoacyl tRNA synthase complex-interacting multifunctional protein 2

Status: VALIDATED

Source sequence(s)

AC005995, BC002853

Consensus CDS

CCDS5344.1

UniProtKB/Swiss-Prot

Q13155

Related

ENSP00000223029, OTTHUMP00000151158, ENST00000223029, OTTHUMT00000242834

Conserved Domains (1) summary

cd03200
Location:214 – 309
Blast Score: 432

GST_C_AIMP2; Glutathione S-transferase C-terminal-like, alpha helical domain of Aminoacyl tRNA synthetase complex-Interacting Multifunctional Protein 2

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p10 Primary Assembly

Genomic

NC_000007.13 Reference GRCh37.p10 Primary Assembly

Range

6048882..6063465

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000139.1 Alternate HuRef

Range

5920617..5935248

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CRA_TCAGchr7v2

Genomic

AC_000068.1 Alternate CRA_TCAGchr7v2

Range

6095227..6109810

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.0

Genomic

NC_018918.1 Alternate CHM1_1.0

Range

6020806..6035443

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	ABBA01029369.1 (4946..10317)	None
genomic	ABBA01029370.1	None
genomic	AC005995.3	AAS00389.1
genomic	AMYH01017029.1 (28621..29308)	None
genomic	AMYH01017030.1	None
genomic	CH236963.1	EAL23713.1
genomic	CH878731.1	EAW55053.1
		EAW55054.1
mRNA	AF116615.2	AAF71039.1
mRNA	AK313037.1	BAG35870.1
mRNA	BC002853.1	AAH02853.1
mRNA	BC010156.1	AAH10156.1
mRNA	BC013630.1	AAH13630.1
mRNA	U24169.1	AAC50391.1