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    AIMP2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 [ Homo sapiens ]

    Gene ID: 7965, updated on 11-May-2012
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    Summary

    Official Symbol
    AIMP2provided by HGNC
    Official Full Name
    aminoacyl tRNA synthetase complex-interacting multifunctional protein 2provided by HGNC
    Primary source
    HGNC:20609
    Locus tag
    PRO0992
    See related
    Ensembl:ENSG00000106305; HPRD:02915; MIM:600859; Vega:OTTHUMG00000122077
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    P38; JTV1; JTV-1; PRO0992
    Summary
    The JTV1 gene is located on chromosome 7p22 flanked by two genes, HRI and PMS2. JTV1 and HRI overlap slightly and are arranged in a tail-to-tail fashion. JTV1 and PMS2 are separated by approximately 200 base pairs and are arranged head-to-head. JTV1 is transcribed in the opposite direction compared to HRI and PMS2. The function of the JTV1 gene product is unknown. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    7p22
    Sequence :
    Chromosome: 7; NC_000007.13 (6048882..6063465)
    See AIMP2 in Epigenomics, MapViewer

    Chromosome 7 - NC_000007.13Genomic Context describing neighboring genes Neighboring gene radial spoke head 10 homolog B (Chlamydomonas) Neighboring gene PMS2 postmeiotic segregation increased 2 (S. cerevisiae) Neighboring gene eukaryotic translation initiation factor 2-alpha kinase 1 Neighboring gene ubiquitin specific peptidase 42 Neighboring gene cytohesin 3

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. A directed protein interaction network for investigating intracellular signal transduction. Vinayagam A, et al. Sci Signal, 2011 Sep 6. PMID 21900206.
    2. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    3. Cancer-associated splicing variant of tumor suppressor AIMP2/p38: pathological implication in tumorigenesis. Choi JW, et al. PLoS Genet, 2011 Mar. PMID 21483803.
    4. Novel regulation of parkin function through c-Abl-mediated tyrosine phosphorylation: implications for Parkinson's disease. Imam SZ, et al. J Neurosci, 2011 Jan 5. PMID 21209200.
    5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048.

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. a splicing variant of AIMP2 lacking exon 2 (AIMP2-DX2) is highly expressed by alternative splicing in human lung cancer cells and patient's tissues
      Title: Cancer-associated splicing variant of tumor suppressor AIMP2/p38: pathological implication in tumorigenesis.
    2. Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China.
    3. Observational study of gene-disease association. (HuGE Navigator)
      Title: Genetic susceptibility to distinct bladder cancer subphenotypes.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_006294.2 NP_004437.1 EPRS    BIND  PubMed p38 interacts with GluProRS. 
    NP_006294.2 NP_005539.1 KARS    BIND  PubMed p38 interacts with LysRS. 
    Q13155 Q12904 AIMP1    HPRD  PubMed  
    Q13155 Q13155 AIMP2    HPRD  PubMed  
    Q13155 Chromosome 19 open reading frame 57 C19orf57    HPRD  PubMed  
    Q13155 P14868 DARS    HPRD  PubMed  
    Q13155 P07814 EPRS    HPRD  PubMed  
    Q13155 Q12929 EPS8    HPRD  PubMed  
    Q13155 Q13643 FHL3    HPRD  PubMed  
    Q13155 Q96AE4 FUBP1    HPRD  PubMed  
    Q13155 Q15046 KARS    HPRD  PubMed  
    Q13155 Q8TAP4 LMO3    HPRD  PubMed  
    Q13155 Q8TBB1 LNX1    HPRD  PubMed  
    Q13155 O60260 PARK2    HPRD  PubMed  
    BioGRID:113684 BioGRID:106575 ACTB    BioGRID  PubMed Two-hybrid 
    BioGRID:113684 BioGRID:113684 AIMP2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113684 BioGRID:122590 C19orf57    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:113684 BioGRID:570479 CEP170P1    BioGRID  PubMed Two-hybrid 
    BioGRID:113684 BioGRID:107532 CHD3    BioGRID  PubMed Two-hybrid 
    BioGRID:113684 BioGRID:120611 CNO    BioGRID  PubMed Two-hybrid 
    BioGRID:113684 BioGRID:107984 DARS    BioGRID  PubMed Two-hybrid 
    BioGRID:113684 BioGRID:120459 DARS2    BioGRID  PubMed Two-hybrid 
    BioGRID:113684 BioGRID:115777 DEAF1    BioGRID  PubMed Two-hybrid 
    BioGRID:113684 BioGRID:123045 DSN1    BioGRID  PubMed Two-hybrid 
    BioGRID:113684 BioGRID:108373 EPS8    BioGRID  PubMed Two-hybrid 
    BioGRID:113684 BioGRID:108535 FGB    BioGRID  PubMed Two-hybrid 
    BioGRID:113684 BioGRID:108566 FHL3    BioGRID  PubMed Two-hybrid 
    BioGRID:113684 BioGRID:109540 HSPA4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113684 BioGRID:109605 IARS    BioGRID  PubMed Two-hybrid 
    BioGRID:113684 BioGRID:109938 KARS    BioGRID  PubMed Two-hybrid 
    BioGRID:113684 BioGRID:109992 KDR    BioGRID  PubMed Two-hybrid 
    BioGRID:113684 BioGRID:116955 KIAA0947    BioGRID  PubMed Two-hybrid 
    BioGRID:113684 BioGRID:121617 KIAA1377    BioGRID  PubMed Two-hybrid 
    BioGRID:113684 BioGRID:122313 KLC2    BioGRID  PubMed Two-hybrid 
    BioGRID:113684 BioGRID:120977 LMO3    BioGRID  PubMed Two-hybrid 
    BioGRID:113684 BioGRID:124219 LNX1    BioGRID  PubMed Two-hybrid 
    BioGRID:113684 BioGRID:119646 LUC7L2    BioGRID  PubMed Two-hybrid 
    BioGRID:113684 BioGRID:115126 MATR3    BioGRID  PubMed Two-hybrid 
    BioGRID:113684 BioGRID:116865 MCF2L    BioGRID  PubMed Two-hybrid 
    BioGRID:113684 BioGRID:111105 PARK2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:113684 BioGRID:111510 PPP2R1A    BioGRID  PubMed Two-hybrid 
    BioGRID:113684 BioGRID:111692 PSME1    BioGRID  PubMed Two-hybrid 
    BioGRID:113684 BioGRID:111797 QARS    BioGRID  PubMed Two-hybrid 
    BioGRID:113684 BioGRID:111852 RARS    BioGRID  PubMed Two-hybrid 
    BioGRID:113684 BioGRID:115563 STUB1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113684 BioGRID:113010 TP53    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:113684 BioGRID:117968 TRMT2A    BioGRID  PubMed Two-hybrid 
    BioGRID:113684 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:113684 BioGRID:123141 ZC3H12A    BioGRID  PubMed Two-hybrid 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Cytosolic tRNA aminoacylation, organism-specific biosystem (from REACTOME)
      Cytosolic tRNA aminoacylation, organism-specific biosystemCytosolic tRNA synthetases catalyze the reactions of tRNAs encoded in the nuclear genome, their cognate amino acids, and ATP to form aminoacyl-tRNAs, AMP, and pyrophosphate. Eight of the tRNA synthet...
    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • Keap1-Nrf2 Pathway, organism-specific biosystem (from WikiPathways)
      Keap1-Nrf2 Pathway, organism-specific biosystemBased on [http://www.nature.com/nrc/journal/v3/n10/fig_tab/nrc1189_F4.html Surh, 2003, figure 4].
    • tRNA Aminoacylation, organism-specific biosystem (from REACTOME)
      tRNA Aminoacylation, organism-specific biosystemtRNA synthetases catalyze the ligation of tRNAs to their cognate amino acids in an ATP-dependent manner. The reaction proceeds in two steps. First, amino acid and ATP form an aminoacyl adenylate mole...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    gene expression TAS
    Traceable Author Statement
    more info
    		  
    multicellular organismal development IEA
    Inferred from Electronic Annotation
    more info
    		  
    tRNA aminoacylation for protein translation TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytosol TAS
    Traceable Author Statement
    more info
    		  
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    aminoacyl tRNA synthase complex-interacting multifunctional protein 2
    Names
    aminoacyl tRNA synthase complex-interacting multifunctional protein 2
    JTV1
    protein JTV-1
    ARS-interacting multi-functional protein 2
    multisynthase complex auxiliary component p38
    multisynthetase complex auxiliary component p38
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006303.3 → NP_006294.2  aminoacyl tRNA synthase complex-interacting multifunctional protein 2

      Status: VALIDATED

      Source sequence(s)
      AC005995, BC002853
      Consensus CDS
      CCDS5344.1
      UniProtKB/Swiss-Prot
      Q13155
      Related
      ENSP00000223029, OTTHUMP00000151158, ENST00000223029, OTTHUMT00000242834
      Conserved Domains (1) summary
      cd03200
      Location:214 – 309
      Blast Score: 432
      GST_C_AIMP2; Glutathione S-transferase C-terminal-like, alpha helical domain of Aminoacyl tRNA synthetase complex-Interacting Multifunctional Protein 2

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000007.13 Reference GRCh37.p5 Primary Assembly

      Range
      6048882..6063465
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000139.1 Alternate HuRef

      Range
      5920617..5935248
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CRA_TCAGchr7v2

    Genomic

    1. AC_000068.1 Alternate CRA_TCAGchr7v2

      Range
      6095227..6109810
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC005995.3 AAS00389.1
    genomic CH236963.1 EAL23713.1
    genomic CH878731.1 EAW55053.1
      EAW55054.1
    mRNA AF116615.1 AAF71039.1
    mRNA AK313037.1 BAG35870.1
    mRNA BC002853.1 AAH02853.1
    mRNA BC010156.1 AAH10156.1
    mRNA BC013630.1 AAH13630.1
    mRNA U24169.1 AAC50391.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q13155.2 GenPept UniProtKB/Swiss-Prot:Q13155
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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