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PANK3 pantothenate kinase 3 [ Homo sapiens (human) ]

Gene ID: 79646, updated on 8-May-2016
Official Symbol
PANK3provided by HGNC
Official Full Name
pantothenate kinase 3provided by HGNC
Primary source
HGNC:HGNC:19365
See related
Ensembl:ENSG00000120137 HPRD:07312; MIM:606161
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a protein belonging to the pantothenate kinase family. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by CoA. This family member is expressed most abundantly in the liver. [provided by RefSeq, Jul 2008]
Orthologs
Location:
5q34
Exon count:
7
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 5 NC_000005.10 (168555623..168579609, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (167982628..168006614, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene solute carrier family 2 member 3 pseudogene 1 Neighboring gene fibrillarin-like 1 Neighboring gene microRNA 103a-1 Neighboring gene microRNA 103b-1 Neighboring gene ribosomal protein L10 pseudogene 9 Neighboring gene uncharacterized LOC101927969 Neighboring gene slit guidance ligand 3

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Replication interactions

Interaction Pubs
Knockdown of pantothenate kinase 3 (PANK3) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ12899, MGC16863, DKFZp686O22247

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
pantothenate kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
coenzyme A biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
pantothenate kinase 3
Names
hPanK3
pantothenic acid kinase 3
NP_078870.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024594.3NP_078870.1  pantothenate kinase 3

    See identical proteins and their annotated locations for NP_078870.1

    Status: REVIEWED

    Source sequence(s)
    AA831520, AC020894, BC013705, CB045475
    Consensus CDS
    CCDS4368.1
    UniProtKB/Swiss-Prot
    Q9H999
    Related
    ENSP00000239231, OTTHUMP00000160961, ENST00000239231, OTTHUMT00000252793
    Conserved Domains (1) summary
    pfam03630
    Location:12367
    Fumble; Fumble

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p2 Primary Assembly

    Range
    168555623..168579609 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018916.2 Alternate CHM1_1.1

    Range
    167415556..167439549 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)