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lct lactase [ Danio rerio (zebrafish) ]

Gene ID: 796436, updated on 27-Mar-2024

Summary

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Official Symbol
lctprovided by ZNC
Official Full Name
lactaseprovided by ZNC
Primary source
ZFIN:ZDB-GENE-081104-434
See related
Ensembl:ENSDARG00000092404 AllianceGenome:ZFIN:ZDB-GENE-081104-434
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:dkey-79p17.2
Summary
Predicted to enable hydrolase activity, hydrolyzing O-glycosyl compounds. Predicted to act upstream of or within carbohydrate metabolic process. Predicted to be located in membrane. Predicted to be integral component of membrane. Human ortholog(s) of this gene implicated in congenital lactase deficiency. Orthologous to human LCT (lactase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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Location:
chromosome: 9
Exon count:
17
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (46387223..46398843, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (46568647..46595649, complement)

Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene histone deacetylase 4 Neighboring gene lactase-phlorizin hydrolase Neighboring gene uncharacterized LOC110440050 Neighboring gene gap junction protein gamma 4b Neighboring gene uncharacterized LOC103911691 Neighboring gene solute carrier family 4 member 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Expression of fgf23 and αklotho in developing embryonic tissues and adult kidney of the zebrafish, Danio rerio. Mangos S, et al. Nephrol Dial Transplant, 2012 Dec. PMID 22885518, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

General protein information

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Preferred Names
lactase-phlorizin hydrolase

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007120.7 Reference GRCz11 Primary Assembly

    Range
    46387223..46398843 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021479026.1 → XP_021334701.1  lactase-phlorizin hydrolase isoform X2

    UniProtKB/TrEMBL
    A0A8M9QG65
    Related
    ENSDARP00000133633.1, ENSDART00000169044.2
    Conserved Domains (1) summary
    cl23725
    Location:1336 → 1802
    Glyco_hydro_1; Glycosyl hydrolase family 1

  2. XM_021479025.1 → XP_021334700.1  lactase-phlorizin hydrolase isoform X1

    UniProtKB/TrEMBL
    A0A8M9QKD0
    Conserved Domains (1) summary
    cl23725
    Location:1338 → 1804
    Glyco_hydro_1; Glycosyl hydrolase family 1
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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