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MUL1 mitochondrial E3 ubiquitin protein ligase 1 [ Homo sapiens (human) ]

Gene ID: 79594, updated on 1-Aug-2015
Official Symbol
MUL1provided by HGNC
Official Full Name
mitochondrial E3 ubiquitin protein ligase 1provided by HGNC
Primary source
HGNC:HGNC:25762
See related
Ensembl:ENSG00000090432; HPRD:07799; MIM:612037; Vega:OTTHUMG00000002838
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GIDE; MAPL; MULAN; RNF218; C1orf166
Orthologs
See MUL1 in Epigenomics, MapViewer
Location:
1p36.12
Exon count:
5
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 1 NC_000001.11 (20499448..20508181, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (20825941..20834674, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene von Willebrand factor A domain containing 5B1 Neighboring gene long intergenic non-protein coding RNA 1141 Neighboring gene calcium/calmodulin-dependent protein kinase II inhibitor 1 Neighboring gene ribosomal protein S4X pseudogene 4 Neighboring gene family with sequence similarity 43, member B

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ12875

Gene Ontology Provided by GOA

Function Evidence Code Pubs
SUMO transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ligase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
signal transducer activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
activation of JUN kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
activation of cysteine-type endopeptidase activity involved in apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to exogenous dsRNA IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial fission IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitochondrion localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell growth IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of chemokine (C-C motif) ligand 5 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of defense response to virus by host IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of innate immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of mitochondrial fusion IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of protein kinase B signaling IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of type I interferon-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of I-kappaB kinase/NF-kappaB signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of dendrite extension IEA
Inferred from Electronic Annotation
more info
 
positive regulation of mitochondrial fission IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein sumoylation IDA
Inferred from Direct Assay
more info
PubMed 
protein destabilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein stabilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein sumoylation IEA
Inferred from Electronic Annotation
more info
 
protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
regulation of mitochondrial membrane potential IEA
Inferred from Electronic Annotation
more info
 
regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
regulation of mitochondrion organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
axon IMP
Inferred from Mutant Phenotype
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
 
integral component of mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
 
mitochondrion IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuronal cell body IMP
Inferred from Mutant Phenotype
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
peroxisome IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
mitochondrial ubiquitin ligase activator of NFKB 1
Names
E3 SUMO-protein ligase MUL1
E3 ubiquitin ligase
E3 ubiquitin-protein ligase MUL1
growth inhibition and death E3 ligase
mitochondria-anchored protein ligase
mitochondrial E3 ubiquitin ligase 1
mitochondrial ubiquitin ligase activator of NF-kB
mitochondrial-anchored protein ligase
putative NF-kappa-B-activating protein 266
ring finger protein 218
NP_078820.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024544.2NP_078820.2  mitochondrial ubiquitin ligase activator of NFKB 1

    See identical proteins and their annotated locations for NP_078820.2

    Status: VALIDATED

    Source sequence(s)
    AL391357, BC014010
    Consensus CDS
    CCDS208.1
    UniProtKB/TrEMBL
    A0A024RAA0
    UniProtKB/Swiss-Prot
    Q969V5
    Related
    ENSP00000264198, OTTHUMP00000002880, ENST00000264198, OTTHUMT00000007951
    Conserved Domains (2) summary
    cd00162
    Location:302343
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    pfam12483
    Location:114248
    GIDE; E3 Ubiquitin ligase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p2 Primary Assembly

    Range
    20499448..20508181
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011542137.1XP_011540439.1  

    See identical proteins and their annotated locations for XP_011540439.1

    Conserved Domains (2) summary
    cd00162
    Location:263304
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    pfam12483
    Location:75209
    GIDE; E3 Ubiquitin ligase

Alternate CHM1_1.1

Genomic

  1. NC_018912.2 Alternate CHM1_1.1

    Range
    20936341..20945071
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)