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rac3b Rac family small GTPase 3b [ Danio rerio (zebrafish) ]

Gene ID: 795167, updated on 27-Mar-2024

Summary

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Official Symbol
rac3bprovided by ZNC
Official Full Name
Rac family small GTPase 3bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-080220-21
See related
Ensembl:ENSDARG00000020795 AllianceGenome:ZFIN:ZDB-GENE-080220-21
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:175209
Summary
Predicted to enable GTP binding activity; GTPase activity; and protein kinase binding activity. Acts upstream of or within actomyosin structure organization and rhombomere boundary formation. Predicted to be active in several cellular components, including cell cortex; cytoplasmic vesicle; and neuron projection. Is expressed in rhombomere. Orthologous to human RAC3 (Rac family small GTPase 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
chromosome: 12
Exon count:
6
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (3022872..3042029)
105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (2988139..3007296)

Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene WD repeat-containing protein 49-like Neighboring gene leucine rich repeat containing 45 Neighboring gene dicarbonyl/L-xylulose reductase Neighboring gene RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Rac2 Functions in Both Neutrophils and Macrophages To Mediate Motility and Host Defense in Larval Zebrafish. Rosowski EE, et al. J Immunol, 2016 Dec 15. PMID 27837107, Free PMC Article
  2. A single cell transcriptome atlas of the developing zebrafish hindbrain. Tambalo M, et al. Development, 2020 Mar 16. PMID 32094115, Free PMC Article
  3. Evolutionary emergence of the rac3b/rfng/sgca regulatory cluster refined mechanisms for hindbrain boundaries formation. Letelier J, et al. Proc Natl Acad Sci U S A, 2018 Apr 17. PMID 29610331, Free PMC Article
  4. Identification of Potentially Related Genes and Mechanisms Involved in Skeletal Muscle Atrophy Induced by Excessive Exercise in Zebrafish. Sun CC, et al. Biology (Basel), 2021 Aug 10. PMID 34439993, Free PMC Article
  5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in Rac protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within actomyosin structure organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell projection assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cortical cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in engulfment of apoptotic cell IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in establishment or maintenance of cell polarity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in motor neuron axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cell shape IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of neutrophil migration IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within rhombomere boundary formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within small GTPase-mediated signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ras-related C3 botulinum toxin substrate 3b
Names
ras-related C3 botulinum toxin substrate 3b (rho family, small GTP binding protein Rac3)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001320406.1 → NP_001307335.1  ras-related C3 botulinum toxin substrate 3b

    Status: VALIDATED

    Source sequence(s)
    BX548040, EH436479
    UniProtKB/TrEMBL
    A0A8M1P8N9, A9JRY8
    Related
    ENSDARP00000110728.1, ENSDART00000122905.4
    Conserved Domains (1) summary
    cd01871
    Location:3 → 176
    Rac1_like; Ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)-like consists of Rac1, Rac2 and Rac3

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007123.7 Reference GRCz11 Primary Assembly

    Range
    3022872..3042029
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001111218.1: Suppressed sequence

    Description
    NM_001111218.1: This RefSeq was removed because currently there is insufficient support for the transcript.
Nucleotide Protein Strain
Heading Accession and Version

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