BIRC7 baculoviral IAP repeat containing 7 [Homo sapiens] - Gene

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Summary

Official Symbol: BIRC7provided by HGNC
Official Full Name: baculoviral IAP repeat containing 7provided by HGNC
Primary source: HGNC:13702
Locus tag: RP11-261N11.7
See related: Ensembl:ENSG00000101197; HPRD:05761; MIM:605737; Vega:OTTHUMG00000032957
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: KIAP; LIVIN; MLIAP; RNF50; ML-IAP
Summary: The protein encoded by this gene is a member of the family of inhibitor of apoptosis proteins (IAP) and contains a single copy of a baculovirus IAP repeat (BIR) as well as a RING-type zinc finger domain. The BIR domain is essential for inhibitory activity and interacts with caspases, while the RING finger domain sometimes enhances antiapoptotic activity but does not inhibit apoptosis alone. Two transcript variants encoding different isoforms have been found for this gene. The two isoforms have different antiapoptotic properties, with isoform alpha protecting cells from apoptosis induced by staurosporine and isoform b protecting cells from apoptosis induced by etoposide. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 20q13.3

Sequence :: Chromosome: 20; NC_000020.10 (61867276..61871854)

See BIRC7 in Epigenomics, MapViewer

Chromosome 20 - NC_000020.10 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

this review introduces Livin structure, biological function, and its role in cancer formation and progression and the possible interventions for cancer therapy.
Title: Research progress on Livin protein: an inhibitor of apoptosis.
Livin expression is a novel prognostic marker in adult acute leukemia and thus needs to be incorporated into the patient stratification and treatment protocols.
Title: Expression of inhibitor of apoptosis protein (IAP) livin/BIRC7 in acute leukemia in adults: correlation with prognostic factors and outcome.
JNK1, Raf-1 and Livin may be involved in the carcinogenesis of sporadic colorectal tubular adenoma.
Title: [Expression and significance of JNK1, Raf-1 and Livin in the carcinogenesis of sporadic colorectal tubular adenoma].
Livin overexpression at the invasive tumor front of oral squamous cell carcinoma may indicate greater malignancy and higher likeliness of tumor recurrence and metastasis.
Title: [Expression of livin at the invasive tumor front of oral squamous cell carcinoma].
Inhibiting Livin and survivin expression with siRNA reduces colon cancer cell proliferation.
Title: [Inhibitory effect of multiple siRNA recombinant expression vector targeting simultaneously Livin and Survivin genes on human colon cancer cells proliferation].
Livin mRNA and protein are highly expressed in non-Hodgkin's lymphoma patients and are positively correlated with many clinical features.
Title: [Clinical significance of Livin expression in non-Hodgkin's lymphoma].
The expression and correlation of Livin and Smac/DIABLO vary in different stages and pathological types of gastric carcinoma. Overexpression of Livin is closely related to differentiation and metastases of gastric carcinoma.
Title: [Expression and clinical significance of apoptosis associated genes Livin and Smac/DIABLO in human gastric carcinomas].
The positive rate of Livin was higher in LSCC than that in normal soft palate tissue and the expression was significantly associated with lymph node metastasis.
Title: [Expression of Livin in laryngeal squamous cell carcinoma and relationship with bFGF].
VEGF stimulation results in mTOR signaling activation which changes the phosphorylation status of 4E-BP1, the downstream of mTOR signaling, and ultimately contributes to the translation initiation of Livin protein
Title: VEGF stimulation enhances Livin protein synthesis through mTOR signaling.
Livin-alpha may promote cell proliferation by regulating G(1)-S cell cycle transition and possibly play an important part in initiation of prostate cancer.
Title: Livin-α promotes cell proliferation by regulating G1-S cell cycle transition in prostate cancer.

Submit: New GeneRIF Correction See all (50)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
Q96CA5	P42574	CASP3	HPRD	PubMed
Q96CA5	P55210	CASP7	HPRD	PubMed
Q96CA5	P55211	CASP9	HPRD	PubMed
Q96CA5	Q9NR28	DIABLO	HPRD	PubMed
Q96CA5	O43464	HTRA2	HPRD	PubMed
BioGRID:122670	BioGRID:106826	BIRC2	BioGRID	PubMed	Two-hybrid
BioGRID:122670	BioGRID:122670	BIRC7	BioGRID	PubMed	Two-hybrid
BioGRID:122670	BioGRID:107286	CASP3	BioGRID	PubMed	Reconstituted Complex
BioGRID:122670	BioGRID:107290	CASP7	BioGRID	PubMed	Reconstituted Complex
BioGRID:122670	BioGRID:107292	CASP9	BioGRID	PubMed	Affinity Capture-Western
BioGRID:122670	BioGRID:121157	DIABLO	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:122670	BioGRID:113169	UBE2D1	BioGRID	PubMed	Two-hybrid
BioGRID:122670	BioGRID:113170	UBE2D2	BioGRID	PubMed	Two-hybrid
BioGRID:122670	BioGRID:113171	UBE2D3	BioGRID	PubMed	Two-hybrid
BioGRID:122670	BioGRID:113172	UBE2E1	BioGRID	PubMed	Two-hybrid
BioGRID:122670	BioGRID:113177	UBE2I	BioGRID	PubMed	Two-hybrid
BioGRID:122670	BioGRID:109340	UBE2K	BioGRID	PubMed	Two-hybrid
BioGRID:122670	BioGRID:120121	XAF1	BioGRID	PubMed	Affinity Capture-Western

Function	Evidence Code	Pubs
cysteine-type endopeptidase inhibitor activity	TAS Traceable Author Statement more info
enzyme binding	NAS Non-traceable Author Statement more info	PubMed
metal ion binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
ubiquitin-protein ligase activity	IDA Inferred from Direct Assay more info	PubMed
zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
DNA fragmentation involved in apoptotic nuclear change	NAS Non-traceable Author Statement more info	PubMed
activation of JUN kinase activity	NAS Non-traceable Author Statement more info	PubMed
anti-apoptosis	IMP Inferred from Mutant Phenotype more info	PubMed
anti-apoptosis	NAS Non-traceable Author Statement more info	PubMed
apoptotic process	IEA Inferred from Electronic Annotation more info
protein ubiquitination	IDA Inferred from Direct Assay more info	PubMed
regulation of cell proliferation	IDA Inferred from Direct Assay more info
regulation of natural killer cell apoptosis	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
intracellular	IEA Inferred from Electronic Annotation more info
nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

Preferred Names: baculoviral IAP repeat-containing protein 7

Names: baculoviral IAP repeat-containing protein 7; RING finger protein 50; livin inhibitor of apoptosis; kidney inhibitor of apoptosis protein; melanoma inhibitor of apoptosis protein

NP_071444.1

EC 6.3.2.-

NP_647478.1

EC 6.3.2.-

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029552.1 RefSeqGene

Range

5001..9579

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_022161.2 → NP_071444.1 baculoviral IAP repeat-containing protein 7 isoform beta

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site compared to variant 1, resulting in a shorter isoform (beta) lacking an internal segment compared to isoform alpha.

Source sequence(s)

AF301009, AF311388

Consensus CDS

CCDS13512.1

UniProtKB/Swiss-Prot

Q96CA5

Related

ENSP00000345213, OTTHUMP00000031536, ENST00000342412, OTTHUMT00000080113

Conserved Domains (3) summary

cd00022
Location:88 – 155
Blast Score: 259

BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...

pfam13923
Location:230 – 269
Blast Score: 102

zf-C3HC4_2; Zinc finger, C3HC4 type (RING finger)

cl15348
Location:230 – 274
Blast Score: 145

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
NM_139317.1 → NP_647478.1 baculoviral IAP repeat-containing protein 7 isoform alpha

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longer isoform (alpha).

Source sequence(s)

AF301009, AF311388, BC014475

Consensus CDS

CCDS13513.1

UniProtKB/Swiss-Prot

Q96CA5

Related

ENSP00000217169, OTTHUMP00000031537, ENST00000217169, OTTHUMT00000080114

Conserved Domains (3) summary

cd00022
Location:88 – 155
Blast Score: 260

BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...

pfam13923
Location:248 – 287
Blast Score: 105

zf-C3HC4_2; Zinc finger, C3HC4 type (RING finger)

cl15348
Location:248 – 292
Blast Score: 148

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000020.10 Reference GRCh37.p5 Primary Assembly

Range

61867276..61871854

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000152.1 Alternate HuRef

Range

58592813..58597392

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AJ309298.1	CAC37337.1
		CAC37338.1
genomic	AL121827.34	CAC36111.1
		CAC36112.1
		CAX12643.1
genomic	CH471077.2	EAW75302.1
		EAW75303.1
		EAW75304.1
mRNA	AF301009.1	AAG37878.1
mRNA	AF311388.1	AAG33622.1
mRNA	AY358835.1	AAQ89194.1
mRNA	AY358836.1	AAQ89195.1
mRNA	AY517497.1	AAS01729.1
mRNA	BC014475.1	AAH14475.1
other-genetic	DQ893077.2	ABM84003.1
other-genetic	DQ896338.2	ABM87337.1